{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:25:54Z","timestamp":1790886354710,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,8,21]],"date-time":"2024-08-21T00:00:00Z","timestamp":1724198400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P50CA240243"],"award-info":[{"award-number":["P50CA240243"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p><jats:italic>STK11<\/jats:italic> adnexal tumour is a rare, recently described malignant neoplasm that is associated with Peutz\u2013Jeghers syndrome. [Correction added on 3 October 2024, after first online publication: \u2018<jats:italic>ST11<\/jats:italic>\u2019 in preceding sentence has been corrected to \u2018<jats:italic>STK11<\/jats:italic>\u2019 in this version.] It predominantly originates from the para\u2010adnexal soft tissues and often shows secondary involvement of the fallopian tube and ovary. <jats:italic>STK11<\/jats:italic> adnexal tumours have a broad differential diagnosis due to their variable morphology and non\u2010specific immunoprofile, and diagnostic confirmation currently requires sequencing to identify an <jats:italic>STK11<\/jats:italic> mutation. We investigate the diagnostic utility of STK11 (LKB1) immunohistochemistry (IHC) in a cohort of <jats:italic>STK11<\/jats:italic> adnexal tumours and morphological mimics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>IHC for STK11 was performed on 122 tumours, including 17 <jats:italic>STK11<\/jats:italic> adnexal tumours and 105 morphological mimics (10 female adnexal tumours of Wolffian origin, 22 adult granulosa cell tumours, 10 juvenile granulosa cell tumours, four Sertoli\u2013Leydig cell tumours, two Leydig cell tumours, one Sertoli cell tumour, one steroid cell tumour, four extra\u2010ovarian sex cord\u2010stromal tumours, 16 ovarian endometrioid carcinomas, eight tubo\u2010ovarian high\u2010grade serous carcinomas, five ovarian mesonephric\u2010like adenocarcinomas, 14 ovarian carcinosarcomas, five peritoneal malignant mesotheliomas, two pelvic plexiform leiomyomata and one ovarian solid pseudopapillary tumour). All <jats:italic>STK11<\/jats:italic> adnexal tumours showed complete loss of cytoplasmic staining for STK11. All other tumour types showed retained cytoplasmic staining, except for one endometrioid carcinoma with mucinous differentiation which showed complete loss of STK11 expression and a high\u2010grade serous carcinoma with subclonal loss.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>STK11 is a highly sensitive and specific immunohistochemical marker for distinguishing <jats:italic>STK11<\/jats:italic> adnexal tumour from its histological mimics, and can obviate the need for confirmatory molecular studies in the appropriate morphological context.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.15303","type":"journal-article","created":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T06:50:28Z","timestamp":1724309428000},"page":"769-782","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["STK11 (LKB1) immunohistochemistry is a sensitive and specific marker for <i>STK11<\/i> adnexal tumours"],"prefix":"10.1111","volume":"85","author":[{"given":"Amir","family":"Dehghani","sequence":"first","affiliation":[{"name":"Division of Women's and Perinatal Pathology, Department of Pathology Brigham and Women's Hospital, Harvard Medical School  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3088-3946","authenticated-orcid":false,"given":"Aarti E","family":"Sharma","sequence":"additional","affiliation":[{"name":"Division of Women's and Perinatal Pathology, Department of Pathology Brigham and Women's Hospital, Harvard Medical School  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1848-2389","authenticated-orcid":false,"given":"Stephanie E","family":"Siegmund","sequence":"additional","affiliation":[{"name":"Department of Pathology Brigham and Women's Hospital, Harvard Medical School  Boston MA 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USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4042-8389","authenticated-orcid":false,"given":"Jelena","family":"Mirkovic","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Molecular Diagnostics, Sunnybrook Health Sciences Centre University of Toronto  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marisa R","family":"Nucci","sequence":"additional","affiliation":[{"name":"Division of Women's and Perinatal Pathology, Department of Pathology Brigham and Women's Hospital, Harvard Medical School  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7746-1436","authenticated-orcid":false,"given":"Christopher P","family":"Crum","sequence":"additional","affiliation":[{"name":"Division of Women's and Perinatal Pathology, Department of Pathology Brigham and Women's Hospital, Harvard Medical School  Boston MA 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