{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:25:55Z","timestamp":1790886355821,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,9,8]],"date-time":"2024-09-08T00:00:00Z","timestamp":1725753600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Recently, SOX17 has emerged as a promising biomarker for non\u2010mucinous M\u00fcllerian (ovarian and endometrial) carcinomas, demonstrating increased specificity in comparison to PAX8 while maintaining similar sensitivity. However, expression of SOX17 in mesonephric\u2010like adenocarcinoma (MLA), a carcinoma of the female genital tract with uncertain, but probably M\u00fcllerian histogenesis, remains unexplored. This study aims to address this gap.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>SOX17 immunohistochemistry was performed on whole tissue sections from 68 MLAs originating from the endometrium or ovary and seven cervical mesonephric carcinomas, as well as six mesonephric remnants\/hyperplasias. Using a four\u2010tiered scoring system based on distribution and intensity of staining, 68% of MLA displayed a negative\/low (&lt;\u200910%) SOX17 expression pattern, which contrasts with the high expression observed in most M\u00fcllerian carcinomas. However, 22% of MLA demonstrated high SOX17 expression, similar to other endometrial and ovarian carcinomas. Similarly, five of seven (72%) mesonephric carcinomas of the cervix were SOX17\u2010negative, but two cases (28%) were positive. All mesonephric remnants\/hyperplasias were SOX17 negative.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The majority of MLA are negative or exhibit low SOX17 expression, in contrast to the diffuse and strong expression commonly seen in other types of M\u00fcllerian carcinoma. However, a subset of MLAs demonstrate high SOX17 expression. Therefore, absence of SOX17 staining is supportive for MLA when the differential includes another non\u2010mucinous M\u00fcllerian carcinoma. SOX17 may also be useful for differentiating mesonephric remnants\/hyperplasias from M\u00fcllerian malignancies and benign M\u00fcllerian glandular lesions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.15308","type":"journal-article","created":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T04:29:31Z","timestamp":1725856171000},"page":"820-825","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["<scp>SOX17<\/scp> expression in mesonephric\u2010like adenocarcinomas and mesonephric remnants\/hyperplasia of the female genital tract: Expanding its utility as a M\u00fcllerian biomarker"],"prefix":"10.1111","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9764-8986","authenticated-orcid":false,"given":"Xiaoming","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Pathology Stanford University School of Medicine  Stanford CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9178-4370","authenticated-orcid":false,"given":"W. Glenn","family":"McCluggage","sequence":"additional","affiliation":[{"name":"Department of Pathology Belfast Health and Social Care Trust  Belfast UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0309-6680","authenticated-orcid":false,"given":"Brooke E","family":"Howitt","sequence":"additional","affiliation":[{"name":"Department of Pathology Stanford University School of Medicine  Stanford CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8767-8564","authenticated-orcid":false,"given":"Michelle S","family":"Hirsch","sequence":"additional","affiliation":[{"name":"Department of Pathology Brigham and Women's Hospital and Harvard Medical School  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.modpat.2022.100001"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.modpat.2022.100038"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.22708"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-51751-3"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.091793"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2011.01.017"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.2052911"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2007.05.019"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S294164"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2012.191551"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.4161\/epi.5.8.13104"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.06.041"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.abm2496"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.12582"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexmp.2022.104761"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCP7MNCNBCRN8NO"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAP.0000000000000342"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001612"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.12895"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2024.01.015"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001401"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000002039"},{"key":"e_1_2_9_24_1","first-page":"12","article-title":"Mesonephric\u2010like adenocarcinoma of the ovary: clinicopathological and molecular characteristics","volume":"12","author":"Koh HH","year":"2022","journal-title":"Diagnostics (Basel)"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0000000000000102"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31824a72c6"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001766"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000958"}],"container-title":["Histopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/his.15308","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T09:10:34Z","timestamp":1728292234000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/his.15308"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,8]]},"references-count":27,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1111\/his.15308"],"URL":"https:\/\/doi.org\/10.1111\/his.15308","archive":["Portico"],"relation":{},"ISSN":["0309-0167","1365-2559"],"issn-type":[{"value":"0309-0167","type":"print"},{"value":"1365-2559","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,8]]},"assertion":[{"value":"2024-04-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}