{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T03:00:49Z","timestamp":1792119649290,"version":"4.4.0"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T00:00:00Z","timestamp":1726185600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008459","name":"University of Calgary","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008459","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>BRCA1\u2010associaed protein\u20101 (BAP1) inactivated tumours (BIMT) are rare melanocytic tumours that may be mistaken for Spitz tumours or melanoma. They occur sporadically or in association with the BAP1 tumour predisposition syndrome (BAP1\u2013TPDS), which may be complicated by uveal or cutaneous melanoma, mesothelioma, basal cell carcinoma and renal cell carcinoma. The aim of this study was to characterise the clinicopathological features and the immunohistochemical expression pattern of preferentially expressed antigen in melanoma (PRAME) of BIMT in a large patient cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Ethical approval was obtained, haematoxylin and eosin\u2010stained slides were reviewed, PRAME immunohistochemistry was performed and clinical follow\u2010up was obtained from patient records. Sixty\u2010five BIMT from 38 patients (F:M\u2009=\u20094.4:1) were identified. BIMT were typically located on the trunk and head and neck (median size\u2009=\u20090.5\u2009cm). Seven patients with BAP1\u2013TPDS (range\u2009=\u200916\u201366\u2009years, median\u2009=\u200925) had multiple BIMT (median\u2009=\u20095), while sporadic BIMT were solitary (median patient age\u2009=\u200939\u2009years). One of seven patients with BAP1\u2013TPDS developed additional malignancies (mesothelioma and cutaneous spindle cell melanoma) and died of complications of mesothelioma. All other patients are alive without recurrence of BIMT (median follow\u2010up\u2009=\u200942\u2009months). BIMT presented as intradermal, nodular aggregates of epithelioid melanocytes with low mitotic activity and moderate to severe cytological atypia in 63% of cases. A background conventional naevus was present in 64%. PRAME immunohistochemistry showed negative or weakly patchy positive staining in all BIMT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>BIMT are more common in a sporadic setting and behave indolently, despite worrying cytological atypia. PRAME immunohistochemistry is a reassuring tool in distinguishing BIMT from melanoma.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.15318","type":"journal-article","created":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T08:46:44Z","timestamp":1726217204000},"page":"294-301","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["BRCA1\u2010associated\u2010protein\u20101 inactivated melanocytic tumours: characterisation of the clinicopathological spectrum and immunohistochemical expression pattern of preferentially expressed antigen in melanoma"],"prefix":"10.1111","volume":"86","author":[{"given":"Yitong","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of Calgary  Calgary AB Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2573-8074","authenticated-orcid":false,"given":"Alejandro A","family":"Gru","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Virginia  Charlottesville VA USA"},{"name":"Department of Pathology New York\u2013Presbyterian Hospital\/Columbia University Irving Medical Center  New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0089-0352","authenticated-orcid":false,"given":"Thomas","family":"Brenn","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of Calgary  Calgary AB Canada"},{"name":"Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary  Calgary AB Canada"},{"name":"Department of Pathology University of Michigan  Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0754-2393","authenticated-orcid":false,"given":"Katharina","family":"Wiedemeyer","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of Calgary  Calgary AB Canada"},{"name":"Department of Pathology University of Michigan  Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,13]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-021-00976-7"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAT.0b013e32835d0efb"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.910"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics12071710"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2015-0207-RA"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001134"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.13958"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/cjp2.86"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.14797"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2024.155162"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.13530"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.05.005"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3182498be5"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djy171"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.12493"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.14346"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.23866"},{"key":"e_1_2_11_19_1","first-page":"717","article-title":"A population\u2010based analysis of germline bap1 mutations in melanoma","volume":"26","author":"O'Shea SJ","year":"2017","journal-title":"Hum. Mol. Genet."},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-019-6226-8"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.13905"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0000000000002584"}],"container-title":["Histopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/his.15318","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T13:21:57Z","timestamp":1734700917000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/his.15318"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,13]]},"references-count":21,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1111\/his.15318"],"URL":"https:\/\/doi.org\/10.1111\/his.15318","archive":["Portico"],"relation":{},"ISSN":["0309-0167","1365-2559"],"issn-type":[{"value":"0309-0167","type":"print"},{"value":"1365-2559","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,13]]},"assertion":[{"value":"2024-07-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}