{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:16:00Z","timestamp":1790140560067,"version":"4.0.1"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T00:00:00Z","timestamp":1728432000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Although turmeric is commonly ingested and well tolerated, there is increasing evidence that over\u2010the\u2010counter turmeric supplements can cause drug\u2010induced liver injury. We sought to thoroughly characterise clinicopathological features of patients for whom liver injury was attributed clinically to turmeric supplements.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>We identified 11 patients via retrospective pathology archive review: 10 females (91%) and one male, with a median age of 58\u2009years (range\u2009=\u200937\u201366\u2009years). Six patients (55%) were asymptomatic with abnormal liver function tests, while five patients (45%) presented with malaise and\/or jaundice. Ten patients (91%) showed predominant transaminase abnormalities, while one exhibited predominant alkaline phosphatase elevation. Histologically, biopsies showed acute hepatitis (eight cases, 73%, including five pan\u2010lobular and three zone 3\u2010predominant inflammation), scattered lobular aggregates of histiocytes (two; 18%) and a chronic hepatitis pattern of injury (one; 9%). Mild bile duct injury was present in five biopsies (45%). All patients stopped ingesting turmeric supplements after presenting with liver injury, and four patients additionally received steroid therapy; liver function tests normalised in all patients. Roussel Uclaf causality assessment method (RUCAM) analysis estimated the likelihood of turmeric supplement\u2010associated liver injury to be probable (eight cases) and possible (three).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Histological features in the \u2018possible\u2019 cases were consistent with drug\u2010induced injury, highlighting the added benefit of histological analysis relative to RUCAM analysis isolation. This study underscores the need to obtain a full history of over\u2010the\u2010counter medications and supplements when investigating aetiologies for liver injury, including supplements purportedly containing innocuous compounds such as turmeric.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.15333","type":"journal-article","created":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T08:40:41Z","timestamp":1728463241000},"page":"410-422","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Turmeric supplement\u2010associated hepatitis: a clinicopathological series of 11 cases highlighting pan\u2010lobular and zone 3 injury"],"prefix":"10.1111","volume":"86","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7746-3546","authenticated-orcid":false,"suffix":"Jr","given":"David J","family":"Papke","sequence":"first","affiliation":[{"name":"Department of Pathology Brigham and Women's Hospital and Harvard Medical School  Boston 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