{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T19:56:04Z","timestamp":1789588564791,"version":"build-2803163510"},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T00:00:00Z","timestamp":1727913600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Pleomorphic adenoma (PA) with a prominent trabecular\/canalicular morphology has consistent HMGA2 protein expression, and association with <jats:italic>HMGA2<\/jats:italic> fusions. We report our experience with this subtype, with emphasis on the carcinomas that can arise in this context.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>A retro\u2010 and prospective review (2013\u20132024) of major salivary gland tumours with prominent trabecular\/canalicular morphology was performed. Twenty\u2010one parotid tumours met the criteria: 14 benign (66.7%), six carcinomas (28.6%), and one of uncertain behaviour (4.7%). HMGA2 immunohistochemistry (IHC) was performed on all cases. Next\u2010generation sequencing was successfully performed on 18. Seven benign cases had a conventional PA component. In all cases, the tumour cells in these trabecular\/canalicular areas demonstrated variable papillary thyroid carcinoma\u2010like nuclear changes, including chromatin clearing, overcrowding, membrane irregularities, and intranuclear pseudoinclusions. Benign tumours were well\u2010demarcated, whereas carcinomas demonstrated either a multinodular pattern of invasion or subtle infiltration. Two carcinomas showed increased cytologic atypia and architectural complexity and one had perineural invasion. By IHC, all were positive for HMGA2. In the trabecular\/canalicular areas, there was consistent strong expression of CAM5.2, S\u2010100, and SOX\u201010 and variable expression of p63 but negative p40. <jats:italic>HMGA2<\/jats:italic> alterations were detected in 16 of 18 cases (89%). Follow\u2010up was available on two carcinomas, with one being locally recurrent.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>While most HMGA2\u2010positive salivary gland neoplasms with a prominent trabecular\/canalicular growth pattern are benign, they, like traditional PAs, may give rise to carcinomas that can locally recur. These carcinomas can be deceptively bland, subtly infiltrative, or have a multinodular pattern of invasion.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.15334","type":"journal-article","created":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T10:40:16Z","timestamp":1727952016000},"page":"385-396","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["HMGA2\u2010positive salivary gland neoplasms with prominent trabecular\/canalicular morphology: a focus on carcinomas arising within this phenotype"],"prefix":"10.1111","volume":"86","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-9877-3891","authenticated-orcid":false,"given":"Melad N","family":"Dababneh","sequence":"first","affiliation":[{"name":"Department of Pathology Heersink School of Medicine, The University of Alabama at Birmingham  Birmingham AL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9667-5392","authenticated-orcid":false,"given":"Elizabeth M","family":"Azzato","sequence":"additional","affiliation":[{"name":"Robert J. Tomsich Department of Pathology and Laboratory Medicine Cleveland Clinic  Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4648-0356","authenticated-orcid":false,"given":"Joy","family":"Nakitandwe","sequence":"additional","affiliation":[{"name":"Robert J. Tomsich Department of Pathology and Laboratory Medicine Cleveland Clinic  Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6458-5517","authenticated-orcid":false,"given":"Vincent","family":"Cracolici","sequence":"additional","affiliation":[{"name":"Robert J. Tomsich Department of Pathology and Laboratory Medicine Cleveland Clinic  Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akeesha A","family":"Shah","sequence":"additional","affiliation":[{"name":"Robert J. Tomsich Department of Pathology and Laboratory Medicine Cleveland Clinic  Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,3]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.path.2016.11.004"},{"key":"e_1_2_11_3_1","volume-title":"WHO classification of Tumours; head and neck Tumours","author":"Skalova A","year":"2022"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.4103\/jomfp.JOMFP_91_19"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000479070"},{"key":"e_1_2_11_6_1","volume-title":"WHO classification of Tumours; head and neck Tumours","author":"Skalova A","year":"2022"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-013-0462-z"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001783"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2020-0336-OA"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1754"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.MP.0000092954.42656.94"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2015.3099"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.15074"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20619"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20402"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.14840"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-014-0554-4"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.13246"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-011-1063-4"}],"container-title":["Histopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/his.15334","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T01:40:30Z","timestamp":1748310030000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/his.15334"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,3]]},"references-count":18,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1111\/his.15334"],"URL":"https:\/\/doi.org\/10.1111\/his.15334","archive":["Portico"],"relation":{},"ISSN":["0309-0167","1365-2559"],"issn-type":[{"value":"0309-0167","type":"print"},{"value":"1365-2559","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,3]]},"assertion":[{"value":"2024-06-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}