{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T10:52:11Z","timestamp":1773312731229,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T00:00:00Z","timestamp":1733270400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Primary cutaneous marginal zone lymphoma (PCMZL) is considered a lymphoproliferative disorder (International Consensus Classification, ICC) or an overt lymphoma (WHO\u2010HAEM5). Seeking evidence for a reactive process or true lymphoma, we retrieved recurrent PCMZLs from the French Study Group of Cutaneous Lymphoma (GFELC) database.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Histology, phenotype (light\u2010chain restriction, immunoglobulin, and immune\u2010receptor translocation\u2010associated protein\u20101 [IRTA1] expression) and B\u2010cell clonality at diagnosis and recurrence were compared according to recurrence site (local, locoregional, or distant) and outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Initial lesions of the 61 patients (mean age 52) were mostly isolated on the trunk (48%) and classified T1 (70%). Times to first recurrence for local, locoregional, and distant recurrences, were 20, 29, and 37\u2009months, respectively. Light\u2010chain restriction type did not differ significantly between local\/locoregional recurrences and distal recurrences (<jats:italic>P<\/jats:italic>\u2009=\u20090.06; <jats:italic>n<\/jats:italic>\u2009=\u200960). The same B\u2010cell clones were identified for 23\/42 local\/locoregional recurrences, while 5\/19 distant recurrences showed different clonal profiles (<jats:italic>P<\/jats:italic>\u2009=\u20090.0003). No tumour expressed IRTA1. Fifty\u2010eight tumours were heavy\u2010chain (IgG\/IgG4) class\u2010switched PCMZLs and 3 IgM+\/IgD\u2013 PCMZLs. All IgM+ tumours underwent either transformation (skin or brain) into diffuse large B\u2010cell lymphomas (DLBCLs) and extracutaneous spreading.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>As suggested by WHO\u2010HAEM5, immunoglobulin phenotype assessment (IgM alongside IgD) appears to be a possible valuable tool in the initial diagnosis of PCMZL to differentiate between the indolent class\u2010switched PCMZL (IgM\u2010negative) and IgM+ (IgD\u2013) PCMZL, which has an uncertain prognosis. The variation in B\u2010cell rearrangements and light chain restriction observed in distant recurrences of PCMZL may suggest different antigen\u2010driven stimulation processes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.15377","type":"journal-article","created":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T08:44:59Z","timestamp":1733301899000},"page":"704-714","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Recurrent primary cutaneous marginal zone lymphoma: a\u00a0comparative study of initial tumours, recurrences, and\u00a0outcomes in 61 patients"],"prefix":"10.1111","volume":"86","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-1202-0019","authenticated-orcid":false,"given":"Fanny","family":"Beltzung","sequence":"first","affiliation":[{"name":"Pathology Department CHU de Bordeaux  Bordeaux France"},{"name":"University of Bordeaux, Inserm, UMR1312, BRIC, Bordeaux Institute of Oncology  Bordeaux France"},{"name":"French Study Group of Cutaneous Lymphomas  France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6150-1229","authenticated-orcid":false,"given":"Marie","family":"Beylot\u2010Barry","sequence":"additional","affiliation":[{"name":"University of Bordeaux, Inserm, UMR1312, BRIC, Bordeaux Institute of Oncology  Bordeaux France"},{"name":"French Study Group of Cutaneous Lymphomas  France"},{"name":"Dermatology Department CHU de Bordeaux  Bordeaux France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7053-7431","authenticated-orcid":false,"given":"Maxime","family":"Battistella","sequence":"additional","affiliation":[{"name":"French Study Group of Cutaneous Lymphomas  France"},{"name":"Pathology Department H\u00f4pital Saint Louis, AP\u2010HP. 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