{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T08:13:30Z","timestamp":1776154410030,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T00:00:00Z","timestamp":1733702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Unusual morphologic patterns of breast carcinomas can raise diagnostic consideration for metastasis or special breast cancer subtypes with management implications. We describe rare invasive breast cancers that mimic serous carcinoma of the gynaecologic tract (serous\u2010like breast carcinomas, SLBC) and characterize their clinicopathologic, immunophenotypic, and genetic features.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>All patients were female (<jats:italic>n<\/jats:italic>\u2009=\u200915, median age 49\u2009years) without a history of gynaecologic malignancy. SLBC were characterized histologically by angulated, branched, sometimes anastomosing glands with micropapillary and\/or pseudopapillary luminal projections in desmoplastic stroma. Most SLBC were triple\u2010negative (TN, <jats:italic>n<\/jats:italic>\u2009=\u200910) or HER2\u2010positive (<jats:italic>n<\/jats:italic>\u2009=\u20092) and grade 2 or 3, while some were oestrogen receptor (ER) low\u2010positive\/HER2\u2010negative and low\u2010grade (<jats:italic>n<\/jats:italic>\u2009=\u20093). CK5\/6 was positive irrespective of grade or receptor status (10\/10). All SLBC expressed GATA3 (14\/15), TRPS1 (7\/7), and\/or mammaglobin (4\/13). SOX10 was positive in most TN (9\/10) and all ER low\u2010positive (3\/3) cases, but negative in HER2\u2010positive tumours. WT1 was universally negative, and PAX8 was focal in one mammaglobin\u2010positive tumour. All ER\u2010negative SLBC were p53\u2010aberrant and 9\/11 were p16\u2010aberrant, whereas ER\u2010positive tumours were wildtype for both markers (3\/3). <jats:italic>TP53<\/jats:italic> was the only frequently mutated gene, altered in all ER\u2010negative (10\/10) but no ER\u2010positive (0\/4) tumours. Clinical behaviour was variable. Only 1\/6 patients achieved pathologic complete response to neoadjuvant chemotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>SLBC is a rare morphologic pattern of invasive breast carcinoma that mimics metastatic serous gynaecologic carcinoma, a potential diagnostic pitfall. SLBC are heterogeneous with respect to grade, receptor profile, and oncogenic driver alterations, without specific genetic underpinnings identified. Additional studies are warranted to further evaluate the clinical behaviour of these tumours.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.15385","type":"journal-article","created":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T07:29:15Z","timestamp":1733815755000},"page":"779-792","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Serous\u2010like breast carcinomas: immunophenotypic, genetic, and clinicopathologic characterization of a morphologically distinct group of tumours"],"prefix":"10.1111","volume":"86","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5285-0862","authenticated-orcid":false,"given":"Gregor","family":"Krings","sequence":"first","affiliation":[{"name":"Department of Pathology University of California San Francisco  San Francisco California USA"},{"name":"Department of Pathology, Robert J. Tomsich Pathology and Laboratory Medicine Institute Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2417-3294","authenticated-orcid":false,"given":"Eliah R.","family":"Shamir","sequence":"additional","affiliation":[{"name":"Department of Pathology University of California San Francisco  San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7448-9537","authenticated-orcid":false,"given":"Marick","family":"La\u00e9","sequence":"additional","affiliation":[{"name":"Department of Pathology Centre Henri Becquerel  Rouen France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2866-8283","authenticated-orcid":false,"given":"Gregory R.","family":"Bean","sequence":"additional","affiliation":[{"name":"Department of Pathology Stanford University  Stanford California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7220-8247","authenticated-orcid":false,"given":"Miriam D.","family":"Post","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Colorado  Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stuart J.","family":"Schnitt","sequence":"additional","affiliation":[{"name":"Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Breast Oncology Program Dana\u2010Farber Cancer Institute  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3346-8086","authenticated-orcid":false,"given":"Yunn\u2010Yi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pathology University of California San Francisco  San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,12,9]]},"reference":[{"key":"e_1_2_12_2_1","volume-title":"WHO classification of Tumours","author":"WHO Classification of Tumours Editorial Board","year":"2019"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.14786"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11412"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/35021093"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2022-0070-RA"},{"key":"e_1_2_12_7_1","volume-title":"World Health Organization classification of Tumours","author":"Allison KH","year":"2019"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/10668969221133747"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/10668969231209780"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/1066896913501381"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/1066896919892699"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2012.191"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdu450"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.10.6823"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.5858\/134.7.e48"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1200\/JOP.18.00206"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2017.06.014"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-019-0449-8"},{"key":"e_1_2_12_19_1","first-page":"52","article-title":"Serous\u2010like breast carcinoma: A novel subtype of triple\u2010negative breast cancer. 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