{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,5]],"date-time":"2025-04-05T04:25:59Z","timestamp":1743827159383,"version":"3.40.3"},"reference-count":17,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T00:00:00Z","timestamp":1738195200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Subareolar sclerosing ductal hyperplasia (SSDH) is a distinct type of complex sclerosing hyperplastic lesion first described by Rosen in 1987. There have been rare studies investigating SSDH; however, no genetic study has been performed to date.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Seven SSDH cases, diagnosed between 2013 and 2024, were identified. All were subjected to next\u2010generation sequencing (523 genes). Patient ages ranged from 40 to 74\u2009years (median\u2009=\u200946). All lesions were located in the subareolar region. Each showed the characteristic appearance of the lesion, as described in the seminal study, with usual ductal hyperplasia in a densely sclerotic background imparting an \u2018infiltrative\u2019 appearance. None of the cases showed atypical hyperplasia or carcinoma. DNA sequencing identified PI3K pathway alterations in all seven cases: <jats:italic>PIK3CA<\/jats:italic> (<jats:italic>n<\/jats:italic>\u2009=\u2009three, one with two alterations), <jats:italic>PIK3R1<\/jats:italic> (<jats:italic>n<\/jats:italic>\u2009=\u2009three) and <jats:italic>PIK3C3<\/jats:italic> (<jats:italic>n<\/jats:italic>\u2009=\u2009one, with concurrent <jats:italic>FAT1<\/jats:italic> mutation).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>SSDH shows PI3K pathway alterations similar to those seen in other non\u2010atypical and atypical proliferative lesions as well as benign and malignant neoplasms of the breast. This finding may explain the rare association of SSDH with atypical hyperplasia, <jats:italic>in\u2010situ<\/jats:italic> and invasive carcinoma.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.15416","type":"journal-article","created":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T11:15:16Z","timestamp":1738235716000},"page":"824-827","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Subareolar sclerosing ductal hyperplasia shows <scp>PI3K<\/scp> pathway alterations"],"prefix":"10.1111","volume":"86","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1270-553X","authenticated-orcid":false,"given":"Baris","family":"Boyraz","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Weill Cornell Medicine\/New York Presbyterian Hospital  New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Robinson","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Weill Cornell Medicine\/New York Presbyterian Hospital  New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7092-6859","authenticated-orcid":false,"given":"Neal","family":"Lindeman","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Weill Cornell Medicine\/New York Presbyterian Hospital  New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Syed A","family":"Hoda","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Weill Cornell Medicine\/New York Presbyterian Hospital  New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3496-1005","authenticated-orcid":false,"given":"James P","family":"Solomon","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Weill Cornell Medicine\/New York Presbyterian Hospital  New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,1,30]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_8_2_1","DOI":"10.1002\/1097-0142(19870601)59:11<1927::AID-CNCR2820591115>3.0.CO;2-U"},{"doi-asserted-by":"publisher","key":"e_1_2_8_3_1","DOI":"10.1177\/1066896916677288"},{"doi-asserted-by":"publisher","key":"e_1_2_8_4_1","DOI":"10.1016\/j.semcancer.2024.08.004"},{"doi-asserted-by":"publisher","key":"e_1_2_8_5_1","DOI":"10.1042\/BJ20071427"},{"doi-asserted-by":"publisher","key":"e_1_2_8_6_1","DOI":"10.1038\/nrc839"},{"doi-asserted-by":"publisher","key":"e_1_2_8_7_1","DOI":"10.1038\/nature11412"},{"doi-asserted-by":"publisher","key":"e_1_2_8_8_1","DOI":"10.1007\/s10549-009-0406-1"},{"doi-asserted-by":"publisher","key":"e_1_2_8_9_1","DOI":"10.1158\/0008-5472.CAN-08-2660"},{"doi-asserted-by":"publisher","key":"e_1_2_8_10_1","DOI":"10.1158\/0008-5472.CAN-07-6854"},{"doi-asserted-by":"publisher","key":"e_1_2_8_11_1","DOI":"10.1038\/modpathol.2013.197"},{"doi-asserted-by":"publisher","key":"e_1_2_8_12_1","DOI":"10.1111\/his.12897"},{"doi-asserted-by":"publisher","key":"e_1_2_8_13_1","DOI":"10.1038\/modpathol.2012.55"},{"doi-asserted-by":"publisher","key":"e_1_2_8_14_1","DOI":"10.1038\/modpathol.2009.142"},{"doi-asserted-by":"publisher","key":"e_1_2_8_15_1","DOI":"10.1097\/PDM.0b013e318288b346"},{"doi-asserted-by":"publisher","key":"e_1_2_8_16_1","DOI":"10.3892\/ijo.2012.1669"},{"doi-asserted-by":"publisher","key":"e_1_2_8_17_1","DOI":"10.1038\/ng.2538"},{"doi-asserted-by":"publisher","key":"e_1_2_8_18_1","DOI":"10.1111\/his.13043"}],"container-title":["Histopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/his.15416","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,5]],"date-time":"2025-04-05T00:21:34Z","timestamp":1743812494000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/his.15416"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,30]]},"references-count":17,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1111\/his.15416"],"URL":"https:\/\/doi.org\/10.1111\/his.15416","archive":["Portico"],"relation":{},"ISSN":["0309-0167","1365-2559"],"issn-type":[{"type":"print","value":"0309-0167"},{"type":"electronic","value":"1365-2559"}],"subject":[],"published":{"date-parts":[[2025,1,30]]},"assertion":[{"value":"2024-09-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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