{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T12:55:44Z","timestamp":1780491344072,"version":"3.54.1"},"reference-count":16,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T00:00:00Z","timestamp":1738281600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Atypical ductal hyperplasia (ADH) in male breast tissue is a rare condition with limited understanding. We aimed to elucidate the clinicopathological characteristics of ADH in male patients, focusing on its prevalence, presentation, and associated factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>We analysed 40 cases of ADH from 1626 male breast cases encountered between 2013 and 2023. Clinicopathological data were reviewed to identify key features and trends. The mean age of the patients in our cohort was 43\u2009years. ADH was mainly discovered incidentally during the workup for gynecomastia in 85% (34\/40) of cases. Only two cases, 5% (2\/40), initially presented as a palpable mass; one was pure ADH and the other one an ADH with intraductal papilloma (IDP). Nipple discharge was the initial presentation in 7.5% (3\/40) of cases, all of which were associated with IDP. Additionally, 5% (2\/40) of cases were identified due to calcifications on imaging. Excision was the initial diagnostic procedure in 77.5% (31\/40) of cases, and core needle biopsy (CNB) in 22.5% (9\/40). In most patients 70% (28\/40) had unilateral disease, while 84.4% (27\/32) exhibited multifocal lesions, and 90.6% (29\/32) showed cribriform architectural patterns. Notably, 77.3% (17\/22) of patients had a history of medications linked to gynecomastia. During follow\u2010up (9\u2009months to 26\u2009years), two patients developed ductal carcinoma <jats:italic>in situ<\/jats:italic> (DCIS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>ADH in male patients primarily presents incidentally alongside gynecomastia. Multifocality and cribriform patterns are common histological features. The association with medication\u2010induced gynecomastia and the potential progression to DCIS highlight the clinical significance of ADH in males.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.15419","type":"journal-article","created":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T11:13:02Z","timestamp":1738321982000},"page":"1137-1146","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Male breast atypical ductal hyperplasia (<scp>ADH<\/scp>): clinicopathological insights from a rare cohort"],"prefix":"10.1111","volume":"86","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5602-2634","authenticated-orcid":false,"given":"Reham","family":"Al\u2010Refai","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Lenox Hill Hospital  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6286-7932","authenticated-orcid":false,"given":"Amr","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Long Island Jewish Medical Center  New Hyde Park NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudarshana","family":"Roychoudhury","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Long Island Jewish Medical Center  New Hyde Park NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7721-3838","authenticated-orcid":false,"given":"Ahmed","family":"Bendari","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Lenox Hill Hospital  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunder","family":"Sham","sequence":"additional","affiliation":[{"name":"Department of Pathology, Memorial Sloan Kettering Cancer Center  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Kantarovich","sequence":"additional","affiliation":[{"name":"Department of Surgery Lenox Hill Hospital  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0720-6584","authenticated-orcid":false,"given":"Iskender","family":"Genco","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Lenox Hill Hospital  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shabnam","family":"Jaffer","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Lenox Hill Hospital  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4075-1994","authenticated-orcid":false,"given":"Sabina","family":"Hajiyeva","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Lenox Hill Hospital  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,31]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2016.229"},{"key":"e_1_2_10_3_1","unstructured":"Male Breast Cancer Incidence and Mortality United States. 2013\u20132017|CDC. Published November 28 2023. Accessed July 8 2024.https:\/\/www.cdc.gov\/cancer\/uscs\/about\/data\u2010briefs\/no19\u2010male\u2010breast\u2010cancer\u2010incidence\u2010mortality\u2010UnitedStates\u20102013\u20102017.htm."},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.12333"},{"key":"e_1_2_10_5_1","volume-title":"StatPearls [Internet]","author":"Myers DJ","year":"2024"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3348\/jksr.2020.0026"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-09-0745"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13143535"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(11)60671-X"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/8364824"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acra.2018.09.010"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.230016"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.12545"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.4103\/jfcm.JFCM_230_20"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/jscr\/rjz023"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-018-05117-4"},{"key":"e_1_2_10_17_1","unstructured":"The American Society of Breast Surgeons.Consensus guideline on concordance assessment of image\u2010guided breast biopsies and management of borderline or high\u2010risk lesions.2016Available at:https:\/\/www.breastsurgeons.org\/docs\/statements\/Consensus\u2010Guideline\u2010on\u2010Concordance\u2010Assessment\u2010of\u2010Image\u2010Guided\u2010Breast\u2010Biopsies.pdf. Accessed January 18 2022."}],"container-title":["Histopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/his.15419","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T01:22:53Z","timestamp":1746148973000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/his.15419"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,31]]},"references-count":16,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1111\/his.15419"],"URL":"https:\/\/doi.org\/10.1111\/his.15419","archive":["Portico"],"relation":{},"ISSN":["0309-0167","1365-2559"],"issn-type":[{"value":"0309-0167","type":"print"},{"value":"1365-2559","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,31]]},"assertion":[{"value":"2024-09-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}