{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T19:08:43Z","timestamp":1770836923462,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T00:00:00Z","timestamp":1738281600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Benign tumours of the rete testis include mostly cystadenomas and adenomas. A subset with tubular or tubulopapillary architecture shows morphological similarities to Sertoli cell tumours; these neoplasms were previously termed \u201cSertoliform cystadenomas of the rete testis\u201d. In the most recent WHO classification, they have been interpreted as Sertoli cell tumours, not otherwise specified (NOS), with pure intra\u2010rete growth, and therefore excluded as an entity. The remaining cystadenomas of the rete testis vaguely resemble tumours of Mullerian origin arising in the ovaries. In this study we analyse benign tumours of the rete testis, including a subset with Sertoliform features.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>Benign neoplasms of the rete testis were identified through query of consultation and institutional files. Clinicopathologic data were collected, and available slides were reviewed. Cases were assessed using IHC and three separate DNA sequencing panels. Eleven tumours from patients 32\u201378\u2009years old were evaluated. Four were classified as Sertoliform adenomas\/cystadenomas, displaying tubulo\u2010papillary or tubular\/trabecular architecture; all of them were PAX8\u2010positive and lacked nuclear beta\u2010catenin expression. The remaining seven tumours were benign cystadenomas NOS. Genomic analysis was performed successfully in 10\/11 tumours (including all Sertoliform adenomas\/cystadenomas) and revealed no pathogenic variants in <jats:italic>CTNNB1<\/jats:italic>, <jats:italic>KRAS<\/jats:italic>, or <jats:italic>BRAF.<\/jats:italic><\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Sertoliform cystadenomas of the rete testis differ from Sertoli cell tumours NOS, as evidenced by the absence of molecular markers characteristic of Sertoli cell tumours. The remaining benign cystadenomas lack molecular alterations seen in Mullerian tumors of the ovaries.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.15422","type":"journal-article","created":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T11:02:57Z","timestamp":1738321377000},"page":"35-43","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Analysis of benign neoplasms of the rete testis formerly termed \u201cSertoliform cystadenomas\u201d demonstrates that they are not Sertoli cell tumours with intra\u2010rete growth"],"prefix":"10.1111","volume":"87","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9603-6731","authenticated-orcid":false,"given":"Katrina","family":"Collins","sequence":"first","affiliation":[{"name":"Department of Pathology Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kvetoslava","family":"Michalova","sequence":"additional","affiliation":[{"name":"Department of Pathology Charles University, Faculty of Medicine in Plze\u0148, Bioptical Laboratory, Ltd.  Pilsen Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dario","family":"de Biase","sequence":"additional","affiliation":[{"name":"Solid Tumor Molecular Pathology Laboratory IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna  Bologna Italy"},{"name":"Department of Pharmacy and Biotechnology (FaBit) University of Bologna  Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Costantino","family":"Ricci","sequence":"additional","affiliation":[{"name":"Pathology Unit, DIAP\u2010Dipartimento InterAziendale di Anatomia Patologica di Bologna Maggiore Hospital\u2010AUSL Bologna  Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Tallini","sequence":"additional","affiliation":[{"name":"Solid Tumor Molecular Pathology Laboratory IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna  Bologna Italy"},{"name":"Anatomic Pathology\u2014Department of Medical and Surgical Sciences (DIMEC) University of Bologna  Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0745-2160","authenticated-orcid":false,"given":"Jennifer B","family":"Gordetsky","sequence":"additional","affiliation":[{"name":"Department of Pathology Microbiology and Immunology Vanderbilt University Medical Center  Nashville TN USA"},{"name":"Department of Urology Vanderbilt University Medical Center  Nashville TN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad T","family":"Idrees","sequence":"additional","affiliation":[{"name":"Department of Pathology Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurizio","family":"Colecchia","sequence":"additional","affiliation":[{"name":"Department of Pathology Universit\u00e0, Vita Salute San Raffaele  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas M","family":"Ulbright","sequence":"additional","affiliation":[{"name":"Department of Pathology Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8817-6331","authenticated-orcid":false,"given":"Andres M","family":"Acosta","sequence":"additional","affiliation":[{"name":"Department of Pathology Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,1,31]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1746-1596-8-23"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/1066896917704304"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.2006.02008.x"},{"key":"e_1_2_9_5_1","first-page":"47","article-title":"Sertoliform rete cystadenoma: a report of two cases","volume":"7","author":"Jones MA","year":"1999","journal-title":"J. Urol. Pathol."},{"key":"e_1_2_9_6_1","unstructured":"SrigleyJR N.KO.Adenoma of the collecting ducts and rete testis"},{"key":"e_1_2_9_7_1","first-page":"10","article-title":"Molecular diagnostic of solid tumor using a next generation sequencing custom\u2010designed multi\u2010gene panel","volume":"10","author":"Biase D","year":"2020","journal-title":"Diagnostics (Basel)"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13000-015-0342-9"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000997"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.modpat.2023.100152"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000455"},{"key":"e_1_2_9_12_1","first-page":"270","article-title":"Cysts and epithelial proliferations of the testicular collecting system (including rete testis)","volume":"17","author":"Jones EC","year":"2000","journal-title":"Semin. Diagn. Pathol."},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2016.11.004"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2006.05.029"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-14-1292"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001219"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1210\/endocr\/bqab046"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31829cdbc6"}],"container-title":["Histopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/his.15422","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T23:48:54Z","timestamp":1748908134000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/his.15422"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,31]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1111\/his.15422"],"URL":"https:\/\/doi.org\/10.1111\/his.15422","archive":["Portico"],"relation":{},"ISSN":["0309-0167","1365-2559"],"issn-type":[{"value":"0309-0167","type":"print"},{"value":"1365-2559","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,31]]},"assertion":[{"value":"2024-10-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}