{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T06:38:09Z","timestamp":1792132689158,"version":"4.4.0"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T00:00:00Z","timestamp":1740009600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>BAP1\u2010inactivated melanocytic tumours (BIMTs) occur sporadically and in association with a familial tumour predisposition syndrome involving germline mutations in the BRCA1\u2010associated protein\u20101 (<jats:italic>BAP1<\/jats:italic>) gene. Here we report the clinical features, histopathologic findings, and chromosomal copy number data of 19 BAP1\u2010inactivated melanocytomas (BIMs) and compare their features to those of five BAP1\u2010inactivated melanomas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively searched the Department of Pathology archives and EMERSE (Electronic Medical Record Search Engine) for BIMTs that had undergone single\u2010nucleotide polymorphism (SNP) microarray testing. Clinical history\/follow\u2010up data, detailed histopathologic features, and SNP microarray results were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, four patients (4\/13) with BIMs and available clinical history had features suspicious for a germline <jats:italic>BAP1<\/jats:italic> aberration. In BIMs (19 cases), the BAP1\u2010inactivated component showed variable cytologic features, including epithelioid (predominant), rhabdoid, plasmacytoid, and nevoid morphologies. Sentinel lymph node biopsy was negative in all (6\/6) patients in which this procedure was performed. No patient diagnosed with a BIM with available clinical follow\u2010up (18\/19; mean 38\u2009months) experienced an adverse event. While the histologic appearances of the five melanomas varied, one case resembled a BIM. The median mitotic count was 1\/mm<jats:sup>2<\/jats:sup> (range 0\u20136\u2009mm<jats:sup>2<\/jats:sup>) in BIMs compared to 3\/mm<jats:sup>2<\/jats:sup> (range 1\u20134\/mm<jats:sup>2<\/jats:sup>) in melanomas (<jats:italic>P<\/jats:italic>\u2009=\u20090.04). The median number of copy number alterations (CNAs) was two (range 0\u20136) in indolent cases versus seven (range 6\u201310) in melanomas (<jats:italic>P<\/jats:italic>\u2009=\u20090.0005). The most common molecular aberration after loss of 3p21 was heterozygous loss of the <jats:italic>CDKN2A<\/jats:italic> locus, which unlike homozygous loss has not been associated with melanoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>While most BIMs appear to have a favourable prognosis, even those with multiple CNAs, they deserve careful integration of all clinical and pathologic findings. Although not fully diagnostic, a mitotic count of \u22653\/mm<jats:sup>2<\/jats:sup> and \u22656 CNAs in the appropriate context is supportive of a diagnosis of BAP1\u2010inactivated melanoma.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.15434","type":"journal-article","created":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T10:37:56Z","timestamp":1740047876000},"page":"110-129","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Role of single\u2010nucleotide polymorphism microarray in the classification of <scp>BAP1<\/scp>\u2010inactivated melanocytic tumours"],"prefix":"10.1111","volume":"87","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1114-817X","authenticated-orcid":false,"given":"Joseph S.","family":"Durgin","sequence":"first","affiliation":[{"name":"Department of Dermatology University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4590-8146","authenticated-orcid":false,"given":"Nicholas A.","family":"Zoumberos","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Arkansas  Little Rock Arkansas USA"},{"name":"Department of Dermatology University of Arkansas  Little Rock Arkansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9896-2894","authenticated-orcid":false,"given":"Taylor","family":"Novice","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2524-4509","authenticated-orcid":false,"given":"Douglas R.","family":"Fullen","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Michigan  Ann Arbor Michigan USA"},{"name":"Department of Pathology University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1836-6591","authenticated-orcid":false,"given":"Alexandra C.","family":"Hristov","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Michigan  Ann Arbor Michigan USA"},{"name":"Department of Pathology University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2359-8426","authenticated-orcid":false,"given":"Lori","family":"Lowe","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Michigan  Ann Arbor Michigan USA"},{"name":"Department of Pathology University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1521-4947","authenticated-orcid":false,"given":"Rajiv M.","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Michigan  Ann Arbor Michigan USA"},{"name":"Department of Pathology University of Michigan  Ann Arbor Michigan USA"},{"name":"Cutaneous Pathology WCP Laboratories Inc.  Maryland Heights Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0802-2883","authenticated-orcid":false,"given":"Paul W.","family":"Harms","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Michigan  Ann Arbor Michigan USA"},{"name":"Department of Pathology University of Michigan  Ann Arbor Michigan USA"},{"name":"Rogel Cancer Center University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0874-5616","authenticated-orcid":false,"given":"Aleodor A.","family":"Andea","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Michigan  Ann Arbor Michigan USA"},{"name":"Department of Pathology University of Michigan  Ann Arbor Michigan USA"},{"name":"Roswell Park Comprehensive Cancer Center Department of Pathology  Buffalo New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2504-466X","authenticated-orcid":false,"given":"Scott C.","family":"Bresler","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Michigan  Ann Arbor Michigan USA"},{"name":"Department of Pathology University of Michigan  Ann Arbor Michigan USA"},{"name":"Rogel Cancer Center University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,20]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1502583"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-020-0499-y"},{"key":"e_1_2_10_4_1","unstructured":"WHO Classification of Tumours Editorial Board.Skin tumours[Internet; beta version ahead of print]. 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