{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T20:54:17Z","timestamp":1758056057801,"version":"3.44.0"},"reference-count":16,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,4,13]],"date-time":"2025-04-13T00:00:00Z","timestamp":1744502400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Lymphocytic oesophagitis (LE) is a histological pattern characterised by increased peripapillary lymphocytes and absent or rare granulocytes. Although its association with Crohn's disease (CrD) is established in children, little is known about LE in adult CrD patients. Previous studies have demonstrated immunophenotypical heterogeneity of LE, suggesting its clinical utility in distinguishing CD8 T cell\u2010predominant LE associated with gastroesophageal reflux disease from CD4 T cell\u2010predominant LE associated with other aetiologies. This study aimed to characterise LE and determine its CD4\/CD8 immunoprofile in adults with CrD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>The study included adults with LE and CrD (<jats:italic>n<\/jats:italic>\u2009=\u200919) and those without CrD (<jats:italic>n<\/jats:italic>\u2009=\u200952). CD4\/CD8 lymphocytes were identified by routine immunohistochemistry. The number of lymphocytes was either manually counted or estimated by eye. Compared to patients with LE without Crohn's disease, those with LE and CrD were younger (mean age\u2009=\u200937.9 versus 55.5\u2009years; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001), showed oesophageal ulceration (31.6 versus 0%; <jats:italic>P<\/jats:italic>\u2009=\u20090.0002) and took fewer medications (median\u2009=\u20094 versus 9; <jats:italic>P<\/jats:italic>\u2009=\u20090.0005). LE in CrD was mainly CD4 T cell\u2010predominant (84.2 versus 59.6%; <jats:italic>P<\/jats:italic>\u2009=\u2009non\u2010significant) and with higher CD4\/CD8 T\u00a0cell ratio (median\u2009=\u20092.4 versus 1.1; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.003). When eyeball estimation of CD4\/CD8 lymphocyte predominance was compared to actual counting, approximately one\u2010third of total cases showed discordance, with 81% having estimated proportions of CD4\/CD8 lymphocytes roughly equal.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with LE and CrD are characterised by younger age, oesophageal ulceration and CD4\u2010predominant lymphocytic infiltrate.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.15443","type":"journal-article","created":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T00:59:11Z","timestamp":1744592351000},"page":"368-374","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinicopathological and immunophenotypical characterisation of lymphocytic oesophagitis in adults with Crohn's disease"],"prefix":"10.1111","volume":"87","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0660-9306","authenticated-orcid":false,"given":"Elizabeth Yiru","family":"Wu","sequence":"first","affiliation":[{"name":"Foundation Medicine  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2593-8268","authenticated-orcid":false,"given":"Michael","family":"Drage","sequence":"additional","affiliation":[{"name":"Department of Pathology, Mass General Brigham Harvard Medical School  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5165-8142","authenticated-orcid":false,"given":"Amitabh","family":"Srivastava","sequence":"additional","affiliation":[{"name":"Department of Pathology Memorial Sloan Kettering Cancer Center  New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6643-423X","authenticated-orcid":false,"given":"Mikhail","family":"Lisovsky","sequence":"additional","affiliation":[{"name":"Department of Pathology, Dartmouth\u2010Hitchcock Medical Center Geisel School of Medicine at Dartmouth  Lebanon NH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,4,13]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"191","article-title":"Nature and significance of cells with irregular nuclear contours in esophageal mucosal biopsies","volume":"5","author":"Mangano MM","year":"1992","journal-title":"Mod. 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