{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T18:32:55Z","timestamp":1789237975496,"version":"build-2803163510"},"reference-count":49,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T00:00:00Z","timestamp":1742774400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:sec><jats:label\/><jats:p>NUT carcinoma is a rare malignant neoplasm characterised by recurrent <jats:italic>NUTM1<\/jats:italic> rearrangements, initially reported in the midline. Recently, 10 cases of cutaneous NUT carcinoma with adnexal differentiation harbouring <jats:italic>BRD3::NUTM1<\/jats:italic>, <jats:italic>NSD3::NUTM1<\/jats:italic>, <jats:italic>BRD4::NUTM1<\/jats:italic> or <jats:italic>BRD3::NUTM2B<\/jats:italic> fusions have been reported. Accordingly, \u2018NUT adnexal carcinoma\u2019 (NAC) has been introduced as a provisional tumour entity to the fifth edition of the WHO Classification of Skin Tumours.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>We report the histopathological, molecular genetic and epigenetic features of seven additional cases of NAC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>The cohort consisted of four female and three male patients with a median age of 58\u2009years. Follow\u2010up was available for six cases, and documented diffuse metastatic spreading leading to death at 18\u2009months after diagnosis for one case. Histopathological examination in all cases revealed dermal\/subcutaneous neoplasms composed of poorly differentiated cells with large irregular vesicular nuclei and at least focally prominent nucleoli. All cases showed areas of duct\/gland formation. Using immunohistochemistry, all tumours showed diffuse NUT expression with co\u2010expression of SOX10 in five cases. P63 and P40 were diffusely positive in one case and confined to the periphery of the tumour nests in five cases. Molecular analysis showed <jats:italic>BRD4::NUTM1<\/jats:italic> fusions (<jats:italic>n<\/jats:italic>\u2009=\u20093), <jats:italic>BRD3::NUTM1<\/jats:italic> fusions (<jats:italic>n<\/jats:italic>\u2009=\u20093) and <jats:italic>NSD3::NUTM1<\/jats:italic> (<jats:italic>n<\/jats:italic>\u2009=\u20091). Although being close to this latter group, methylation and transcriptional analysis revealed that NAC formed a unique cluster distinct from extracutaneous NUT carcinoma and <jats:italic>NUTM1<\/jats:italic>\u2010rearranged porocarcinoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results further support the existence of primary cutaneous NAC and suggest that it may represent an entity distinct from extracutaneous NUT carcinoma.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.15444","type":"journal-article","created":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T01:31:04Z","timestamp":1742866264000},"page":"375-387","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Primary cutaneous <scp>NUT<\/scp> adnexal carcinoma: morphologic, genetic and methylation analysis of seven new cases with comparison to extracutaneous <scp>NUT<\/scp> carcinoma and <i>NUTM1<\/i>\u2010rearranged porocarcinoma"],"prefix":"10.1111","volume":"87","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-3949-3728","authenticated-orcid":false,"given":"M\u00e9lanie","family":"Legrand","sequence":"first","affiliation":[{"name":"Department of Pathology, Centre Hospitalier Universitaire de Tours Universit\u00e9 de Tours  Tours France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5411-3893","authenticated-orcid":false,"given":"Baptiste","family":"Louveau","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9  Paris France"},{"name":"INSERM U976, Institut de Recherche Saint\u2010Louis  Paris France"},{"name":"Department of Tumor Genomics and Pharmacology Saint\u2010Louis Hospital, Assistance Publique\u2010H\u00f4pitaux de Paris (AP\u2010HP)  Paris 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