{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T00:10:05Z","timestamp":1748909405263,"version":"3.41.0"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T00:00:00Z","timestamp":1745712000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Bcl2\u2010positive germinal centres (GCs) have never been documented in reactive lymphoid hyperplasia (RLH). Here we describe such phenomenon in paediatric chronic tonsillitis (PCT), addressing the differential diagnosis with paediatric lymphomas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>Six PCT cases with Bcl2\u2010positive GCs were retrieved from a retrospective series of 166 tonsillectomies from children and adolescents. Clinical\u2010pathological data were collected, also considering the status of <jats:italic>IG<\/jats:italic> rearrangements and <jats:italic>BCL2<\/jats:italic> translocations. PCT with Bcl2\u2010positive GCs mostly occurred in males (5\/6 cases; median age: 5\u2009years). Histologically, tonsil architecture was preserved and Bcl2 positivity was documented in a minority of GCs. Bcl2\u2010positive GCs expressed CD10 and Bcl6 and had a high proliferation index. All cases had polyclonal <jats:italic>IG<\/jats:italic> rearrangements without evidence of monotypic kappa and lambda chains by RNAscope. <jats:italic>BCL2<\/jats:italic> translocations were lacking in all the cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Bcl2\u2010positive GCs in PCT are a rare and benign phenomenon, expanding the spectrum of lymphoma\u2010mimicking paediatric RLH.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.15460","type":"journal-article","created":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T03:40:35Z","timestamp":1745811635000},"page":"145-152","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Reactive Bcl2\u2010positive germinal centres in paediatric tonsils: expanding the spectrum of lymphoma mimickers in children and adolescents"],"prefix":"10.1111","volume":"87","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4006-7317","authenticated-orcid":false,"given":"Marco","family":"Pizzi","sequence":"first","affiliation":[{"name":"Pathology Unit, Department of Medicine\u2013DIMED University of Padua School of Medicine  Padua Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2483-2955","authenticated-orcid":false,"given":"Luisa","family":"Lorenzi","sequence":"additional","affiliation":[{"name":"Pathology Unit, Department of Molecular and Translational Medicine University of Brescia  Brescia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2571-5147","authenticated-orcid":false,"given":"Federico","family":"Scarmozzino","sequence":"additional","affiliation":[{"name":"Pathology Unit, Department of Medicine\u2013DIMED University of Padua School of Medicine  Padua 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