{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T04:59:10Z","timestamp":1780376350289,"version":"3.54.1"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T00:00:00Z","timestamp":1753056000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Sloughing of the oesophageal squamous mucosa may be observed in biopsies from patients with a variety of conditions, in the absence or presence of inflammation. This study aimed to compare the histologic, endoscopic, and clinical findings of patients with histologic features of sloughing, with or without associated inflammation, including a detailed analysis of the medication history.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Retrospective histologic examination was performed on 51 biopsy specimens, with additional bacterial and fungal stains. Cases with sloughing in the absence of inflammation (<jats:italic>n<\/jats:italic>\u2009=\u200922) were classified as sloughing oesophageopathy, while cases with inflammation (<jats:italic>n<\/jats:italic>\u2009=\u200929) were classified as acute neutrophilic or eosinophilic sloughing esophagitis, based on the predominant inflammatory cell. As controls, oesophageal biopsies from patients with well\u2010defined forms of oesophagitis were prospectively assessed. For all categories, lesions predominated in the mid\u2010oesophagus (67%). Endoscopic sloughing and use of nasal\/inhaled corticosteroids were more frequently observed in the oesophageopathy group compared to the oesophagitis group (55% versus 22%, <jats:italic>P<\/jats:italic>\u2009=\u20090.03 and 38% versus 10%, <jats:italic>P<\/jats:italic>\u2009=\u20090.04, respectively). Bacteria were more commonly found in the detached epithelium of the oesophageopathy cases (73%), suggesting colonization of the necrotic layer rather than infection. None of the biopsy specimens of patients with well\u2010defined causes of oesophagitis showed sloughing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In conclusion, sloughing of the luminal layer of the squamous mucosa is a histologic feature that may be identified in the absence (oesophageopathy) or presence of inflammation (oesophagitis). The frequent mid\u2010oesophageal involvement and associations with multiple medications suggest that medication\u2010induced oesophageal injury may be a key contributor to this pattern of injury.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.15522","type":"journal-article","created":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T02:48:39Z","timestamp":1753152519000},"page":"598-605","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A reappraisal of oesophageal mucosal biopsy specimens showing sloughing"],"prefix":"10.1111","volume":"87","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7542-739X","authenticated-orcid":false,"given":"Selda","family":"Karaaslan","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine New York\u2010Presbyterian Hospital\/Weill Cornell Medicine  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3736-9925","authenticated-orcid":false,"given":"Lihui","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine New York\u2010Presbyterian Hospital\/Weill Cornell Medicine  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5916-8106","authenticated-orcid":false,"given":"Erika","family":"Hissong","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine New York\u2010Presbyterian Hospital\/Weill Cornell Medicine  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1692-9880","authenticated-orcid":false,"given":"Jose","family":"Jessurun","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine New York\u2010Presbyterian Hospital\/Weill Cornell Medicine  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,21]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/923073"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2011.204"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.13112"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/aqaa195"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-015-3590-3"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181b7ce21"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000003154"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/10935266251322063"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2005.50209.x"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2011-301817"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2012.04.019"},{"key":"e_1_2_10_13_1","first-page":"1","article-title":"Infections of the esophagus: an update on risk factors, diagnosis and management","volume":"31","author":"Hoversten P","year":"2018","journal-title":"Dis. 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