{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T11:58:41Z","timestamp":1778068721764,"version":"3.51.4"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T00:00:00Z","timestamp":1756252800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>To comprehensively characterize the clinicopathologic, immunohistochemical and genomic features of urothelial carcinoma with myxoid and chordoid features (UCMC), a rare histologic subtype of urothelial carcinoma with fewer than 50 reported cases in the literature.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>We retrospectively identified and analysed eight cases of UCMC using clinicopathologic information, immunohistochemistry and molecular profiling by DNA next\u2010generation sequencing. Genomic analysis revealed a heterogeneous molecular profile, with alterations previously implicated in urothelial carcinoma, including p53\/Rb\/cell cycle pathway genes (6\/7 cases), histone modification genes (6\/7 cases) and FGFR3\/PIK3CA signalling pathway genes (5\/7 cases). Actionable variants were present in 6\/7 cases. Classification utilizing immunohistochemical surrogates for basal and luminal subtypes of urothelial carcinoma demonstrated mixed subtypes: three cases with a luminal profile, one case with a basal profile, two cases which were double negative and two cases with a non\u2010specific profile. One case demonstrated a molecular and immunohistochemical profile consistent with plasmacytoid urothelial carcinoma, suggesting that myxoid and chordoid features may overlap with previously recognized histologic subtypes. The five\u2010year overall survival rate was 75%, with varying stages at presentation (pT1\u2013pT3).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>UCMC represents a rare histologic finding, which can be associated with multiple molecular subtypes of urothelial carcinoma and can pose a diagnostic dilemma when identifying potentially aggressive histologic subtypes. It is uncertain whether UCMC represents a distinct histologic subtype, or (more likely) a histologic pattern acquired during tumour evolution. Further investigation is needed to fully understand the biological and clinical significance of this histologic pattern.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.15545","type":"journal-article","created":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T13:10:03Z","timestamp":1756300203000},"page":"757-767","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Clinicopathologic, immunohistochemical and genomic characterization of urothelial carcinoma with myxoid and chordoid features"],"prefix":"10.1111","volume":"87","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-0768-4764","authenticated-orcid":false,"given":"Ting","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Pathology, Massachusetts General Hospital\/Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0929-0940","authenticated-orcid":false,"given":"Mahmut","family":"Akgul","sequence":"additional","affiliation":[{"name":"Department of Pathology, Brigham and Women's Hospital\/Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1848-2389","authenticated-orcid":false,"given":"Stephanie E","family":"Siegmund","sequence":"additional","affiliation":[{"name":"Department of Pathology, Brigham and Women's Hospital\/Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,27]]},"reference":[{"key":"e_1_2_12_2_1","volume-title":"WHO classification of tumours editorial board. 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