{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T04:07:31Z","timestamp":1788667651629,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T00:00:00Z","timestamp":1757030400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Given that pathologists now frequently assess pathologic response following neoadjuvant or perioperative chemoimmunotherapy for NSCLC, we set up a multicentre study to evaluate the current practice of\n                      <jats:styled-content>re<\/jats:styled-content>\n                      gression\n                      <jats:styled-content>gra<\/jats:styled-content>\n                      ding in Germany (Re\u2010GraDE NSCLC).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>133 cases of NSCLC resection specimens following chemoimmunotherapy (IO) were collected from 9 high\u2010volume lung cancer centres in Germany. Case characteristics were obtained from pathology reports\/electronic medical records. In 107 cases, pretreatment biopsies were available on\u2010site.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Residual viable tumour (% RVT) was commonly used to measure therapy response (106\/133 resection specimens, 79.7%). The entire tumour bed was submitted for histology in 55.6% of cases; however, in 18%, a tumour bed of \u22643\u2009cm was not completely submitted. Either Junker or IASLC regression grading was applied in 97.7% of primary tumours and 60.2% of lymph nodes with comparable results. Almost half of the tumours (45.9%) showed pathological complete response (pCR and\/or regression grade (RG) III) with a very weak correlation between % RVT and pretreatment PD\u2010L1 TPS (\n                      <jats:italic>r<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.078,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.007). Pretreatment PD\u2010L1 levels ranged from 0% to 100% (median, 60%) in cases with complete regression, and pCR was observed in 40% of cases with pretreatment PD\u2010L1 TPS &lt;1%.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our multicentre study describes the current practice of histopathological regression grading of NSCLC after IO in Germany, highlighting the widespread use of the Junker system, which is basically comparable to IASLC regression grading. For standardization, we recommend following the IASLC guidelines (submitting of the complete tumour bed if \u22643\u2009cm), while the reporting of % RVT might represent a continuous parameter for therapy response. Our digital nationwide registry, which aims to integrate biopsy results, molecular profiling and % RVT in resection specimens, might develop into a valuable tool to investigate novel predictive biomarkers of IO efficacy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/his.15550","type":"journal-article","created":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T13:38:08Z","timestamp":1757079488000},"page":"869-879","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Current practice of pathologic response assessment following chemoimmunotherapy for non\u2010small cell lung cancer (\n                    <scp>NSCLC<\/scp>\n                    ) in Germany: first real\u2010world data from the multicentre Re\u2010\n                    <scp>GraDE<\/scp>\n                    study"],"prefix":"10.1111","volume":"87","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-9010-7668","authenticated-orcid":false,"given":"Felix","family":"Elsner","sequence":"first","affiliation":[{"name":"Institute of Pathology University Hospital Erlangen  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiane","family":"K\u00fcmpers","sequence":"additional","affiliation":[{"name":"Institute of Pathology University Hospital Schleswig\u2010Holstein  L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7990-6793","authenticated-orcid":false,"given":"German","family":"Ott","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology Robert Bosch Hospital and Dr. Margarete Fischer\u2010Bosch Institute of Clinical Pharmacology  Stuttgart Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"D\u00f6ring","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology Robert Bosch Hospital and Dr. Margarete Fischer\u2010Bosch Institute of Clinical Pharmacology  Stuttgart Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Schildknecht","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology Robert Bosch Hospital and Dr. Margarete Fischer\u2010Bosch Institute of Clinical Pharmacology  Stuttgart Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9148-3794","authenticated-orcid":false,"given":"Annette","family":"Fisseler\u2010Eckhoff","sequence":"additional","affiliation":[{"name":"Department of Pathology und Cytology Dr. Horst\u2010Schmidt\u2010Hospital Wiesbaden  Wiesbaden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8799-0427","authenticated-orcid":false,"given":"Maximilian","family":"von Laffert","sequence":"additional","affiliation":[{"name":"Institute of Pathology University Hospital Leipzig  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8919-2798","authenticated-orcid":false,"given":"Lea","family":"Baier","sequence":"additional","affiliation":[{"name":"Department of Surgery Klinikum Nuernberg, Paracelsus Medical University Nuremberg  Nuremberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1864-0930","authenticated-orcid":false,"given":"Luca","family":"Giulini","sequence":"additional","affiliation":[{"name":"Department of Surgery Klinikum Nuernberg, Paracelsus Medical University Nuremberg  Nuremberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dietmar","family":"Kraus","sequence":"additional","affiliation":[{"name":"Department of Surgery Klinikum Nuernberg, Paracelsus Medical University Nuremberg  Nuremberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9217-466X","authenticated-orcid":false,"given":"Jozef","family":"Zustin","sequence":"additional","affiliation":[{"name":"Gemeinschaftspraxis F\u00fcr Pathologie Regensburg  Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Weber","sequence":"additional","affiliation":[{"name":"Institute of Pathology University of Regensburg  Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamas","family":"Sz\u00f6ke","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Krankenhaus Barmherzige Br\u00fcder Regensburg  Regensburg 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