{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T19:09:29Z","timestamp":1770836969289,"version":"3.50.1"},"reference-count":56,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T00:00:00Z","timestamp":1758153600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Endoscopic mucosal resection (EMR) is widely used for treating Barrett's\u2010related oesophageal dysplasia and low\u2010stage carcinoma. Disease can recur after this procedure. We analysed a large cohort of EMR specimens to assess clinical and histopathologic factors and their relationship to recurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>We conducted a retrospective study of 129 patients who had in total 290 oesophageal EMRs for glandular neoplasia. Patient age, patient sex, specimen fragmentation, intestinal metaplasia, highest\u2010grade lesion, margin status and clearance, cancer invasion depth, lymphovascular invasion, tumour budding (using published guidelines for colorectal carcinoma), post\u2010procedure cryoablation\/radiofrequency ablation and disease recurrence were recorded. Statistical analyses were performed on 227 eligible cases to determine the significance of these factors in local disease recurrence. Adenocarcinoma was the highest\u2010grade lesion in 42% of the 290 specimens, high\u2010grade dysplasia in 36% and low\u2010grade dysplasia in 22%. Mean age at first EMR was 66\u2009years. Among the 227 statistically analysed cases, post\u2010procedure ablation was performed for 111 (49%) and recurrence of same or worse disease was documented in 104 (46%). Tumour depth and budding did not affect recurrence risk. On multivariate analysis, lack of post\u2010procedure ablation was associated with increased recurrence risk for high\u2010grade dysplasia and carcinoma. Additionally, poor differentiation and margin status were associated with increased recurrence risk for specimens with carcinoma. These relationships mostly held true for recurrence of same\/worse neoplasia or recurrence of any neoplasia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Differentiation, margin status and post\u2010EMR ablation influence the risk of local disease recurrence for Barrett's\u2010related adenocarcinoma, while other factors such as tumour budding and lesional depth do not.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/his.15554","type":"journal-article","created":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T09:18:01Z","timestamp":1758187081000},"page":"856-868","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Margin clearance and post\u2010procedure ablation decrease recurrence risk in endoscopic mucosal resections for Barrett's\u2010related neoplasia"],"prefix":"10.1111","volume":"87","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3040-1548","authenticated-orcid":false,"given":"Phoenix D","family":"Bell","sequence":"first","affiliation":[{"name":"Department of Pathology Cleveland Clinic  Cleveland OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7978-7517","authenticated-orcid":false,"given":"Vivek","family":"Kaul","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Rochester Medical Center  Rochester NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krystle M","family":"Bittner","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Rochester Medical Center  Rochester NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5202-2111","authenticated-orcid":false,"given":"Irene Y","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pathology &amp; Laboratory Medicine University of Rochester Medical Center  Rochester NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1286-7413","authenticated-orcid":false,"given":"Aaron R","family":"Huber","sequence":"additional","affiliation":[{"name":"Department of Pathology &amp; Laboratory Medicine University of Rochester Medical Center  Rochester NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5340-5544","authenticated-orcid":false,"given":"Olivia A","family":"Sagan","sequence":"additional","affiliation":[{"name":"Department of Pathology &amp; Laboratory Medicine University of Rochester Medical Center  Rochester NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5758-5482","authenticated-orcid":false,"given":"Wei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pathology Duke University  Durham NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9640-8822","authenticated-orcid":false,"given":"ILKe","family":"Nalbantoglu","sequence":"additional","affiliation":[{"name":"Department of Pathology Yale University  New Haven CT USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5526-4220","authenticated-orcid":false,"given":"Raul S","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Emory University Hospital  Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,18]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-018-5068-6"},{"key":"e_1_2_10_3_1","first-page":"1471","article-title":"Esophageal cancer epidemiology in blacks and whites: racial and gender disparities in incidence, mortality, survival rates and histology","volume":"97","author":"Baquet CR","year":"2005","journal-title":"J. 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