{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T10:30:26Z","timestamp":1780396226350,"version":"3.54.1"},"reference-count":51,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T00:00:00Z","timestamp":1757980800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81972520"],"award-info":[{"award-number":["81972520"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82203180"],"award-info":[{"award-number":["82203180"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>EBV\u2010associated smooth muscle tumour (EBV\u2010SMT) is a rare neoplasm, primarily affecting patients with HIV, post\u2010transplantation (PT), and congenital immunodeficiency (CI). Most EBV\u2010SMT cases were reported by case reports, and genetic analyses are limited. Herein, we describe nine patients with EBV\u2010SMTs to further expand the clinicopathological and genetic spectrum of EBV\u2010SMT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>\n                      Nine patients with EBV\u2010SMTs were identified from 2008 to 2024, and next\u2010generation sequencing (NGS) was performed in six cases with available material. The study comprised four males and five females aged 9\u201360\u2009years old, including two patients with HIV\u2010SMTs, two with PT\u2010SMTs, three with CI\u2010SMTs, one post\u2010immunosuppressive therapy patient, and one clinically immunocompetent patient. Tumours involved liver (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20097), adrenal gland (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20096), retroperitoneum (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20091) and cervical spinal canal (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20091). Histologically, eight cases showed characteristic interlacing fascicles of spindled cells with inflammatory cell infiltration. In one CI\u2010SMT case, the tumour cells exhibited epithelioid morphology in a whorled pattern with obvious atypia. All cases showed SMA and EBER positivity. NGS detected recurrent mutations in\n                      <jats:italic>PIEZO1<\/jats:italic>\n                      (3\/6),\n                      <jats:italic>CYP2B6<\/jats:italic>\n                      (2\/6),\n                      <jats:italic>NQO1<\/jats:italic>\n                      (2\/6),\n                      <jats:italic>NSMCE3<\/jats:italic>\n                      (2\/6), and\n                      <jats:italic>PI4KA<\/jats:italic>\n                      (2\/6). Novel pathogenic mutations in\n                      <jats:italic>MAGT1<\/jats:italic>\n                      and\n                      <jats:italic>CARMIL2<\/jats:italic>\n                      were identified in two CI\u2010SMTs, with the\n                      <jats:italic>MAGT1<\/jats:italic>\n                      mutation linked to a rare immunodeficiency XMEN disease, reported here for the first time.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our study reported nine EBV\u2010SMT cases from heterogeneous immune statuses, with identification of recurrent mutations and pathogenic mutations in some of these tumours, further expanding its clinicopathological and genetic spectrum. Our findings suggest that EBV\u2010SMT cannot be excluded in clinically immunocompetent patients, and further cytogenetic investigations are warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/his.15558","type":"journal-article","created":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T08:40:33Z","timestamp":1758012033000},"page":"827-841","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<scp>EBV<\/scp>\n                    \u2010associated smooth muscle tumour: a clinicopathological and genetic study of nine cases revealing heterogeneous immune statuses and novel pathogenic mutations"],"prefix":"10.1111","volume":"87","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-5836-2746","authenticated-orcid":false,"given":"Wenyi","family":"Jing","sequence":"first","affiliation":[{"name":"Department of Pathology West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0153-3529","authenticated-orcid":false,"given":"Dan","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Pathology Daqing Long Nan Hospital  Daqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3484-6931","authenticated-orcid":false,"given":"Yan","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Pathology West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4619-1822","authenticated-orcid":false,"given":"Sheng","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Pathology, Sichuan Cancer Hospital &amp; Institute, Sichuan Cancer Center, Cancer Hospital Affiliate to School of Medicine University of Electronic Science and Technology of China  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4580-275X","authenticated-orcid":false,"given":"Ting","family":"Lan","sequence":"additional","affiliation":[{"name":"Department of Pathology, Sichuan Cancer Hospital &amp; Institute, Sichuan Cancer Center, Cancer Hospital Affiliate to School of Medicine University of Electronic Science and Technology of China  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3941-1494","authenticated-orcid":false,"given":"Xin","family":"He","sequence":"additional","affiliation":[{"name":"Department of Pathology West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4748-4121","authenticated-orcid":false,"given":"Hongying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,16]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"190","volume-title":"WHO Classification of Tumours of Soft Tissue and Bone","author":"Watanabe R","year":"2020"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2005.05.083"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.2350\/12-01-1135-CR.1"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3171\/2018.3.PEDS17609"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.epsc.2021.101931"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/02688697.2021.1932745"},{"key":"e_1_2_10_8_1","first-page":"56","article-title":"Epstein\u2010barr virus\u2010positive leiomyosarcoma in immunocompetent patients","volume":"40","author":"Al\u2010Tarawneh H","year":"2023","journal-title":"Turk. 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