{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T19:53:45Z","timestamp":1792180425462,"version":"4.4.0"},"reference-count":78,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T00:00:00Z","timestamp":1765497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T00:00:00Z","timestamp":1765497600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    Molecularly defined renal carcinomas (MDRC) represent a heterogeneous group of tumours characterized by disease\u2010defining genetic alterations, and the documentation of these mutations is necessary for their diagnosis. This group includes\n                    <jats:italic>TFE3<\/jats:italic>\n                    \u2010rearranged renal cell carcinoma (RCC),\n                    <jats:italic>TFEB<\/jats:italic>\n                    \u2010rearranged RCC,\n                    <jats:italic>TFEB<\/jats:italic>\n                    \u2010amplified RCC, fumarate hydratase (\n                    <jats:italic>FH<\/jats:italic>\n                    )\u2010deficient RCC, succinate dehydrogenase (\n                    <jats:italic>SDH<\/jats:italic>\n                    )\u2010deficient RCC,\n                    <jats:italic>SMARCB1<\/jats:italic>\n                    \u2010deficient renal medullary carcinoma (RMC),\n                    <jats:italic>ALK<\/jats:italic>\n                    \u2010rearranged RCC, and\n                    <jats:italic>ELOC<\/jats:italic>\n                    \u2010mutated RCC. Although they account for only about 5% of RCC, they are clinically significant due to distinctive biology, frequent diagnostic pitfalls, and therapeutic implications. Many pathology laboratories lack immediate access to fluorescence in situ hybridization (FISH) or next\u2010generation sequencing (NGS) to confirm MDRC; this review emphasizes morphologic recognition and immunohistochemical surrogates, followed by rational triage for ancillary testing when available.\n                  <\/jats:p>","DOI":"10.1111\/his.70039","type":"journal-article","created":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T13:23:30Z","timestamp":1765545810000},"page":"137-148","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Molecularly defined renal cell carcinomas: practical approaches for surgical pathologists"],"prefix":"10.1111","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0929-0940","authenticated-orcid":false,"given":"Mahmut","family":"Akgul","sequence":"first","affiliation":[{"name":"Department of Pathology Brigham and Women's Hospital  Boston MA 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Brown University, and Brown University Health  Providence RI 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