{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:28:06Z","timestamp":1791998886449,"version":"4.4.0"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T00:00:00Z","timestamp":1764115200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T00:00:00Z","timestamp":1764115200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The risk stratification of gastric cancer (GC) is graded by assessing well\u2010established precursor lesions, glandular atrophy (GA), and intestinal metaplasia (IM), resulting in both the operative link on gastritis assessment (OLGA), and intestinal metaplasia (OLGIM) systems. Although the OLGIM stage is reproducible among pathologists, the OLGA system is laborious to calculate and has poor reproducibility. In addition, it does not comprehensively address the severity of both GA and IM as recommended by the Sydney consensus. We aimed to propose the Operative Link on Gastric Intestinal Metaplasia and Glandular Atrophy Assessment (OLGIMA) system, which identifies OLGIM III\u2013IV and upstages 0\u2013II with advanced GA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A cross\u2010sectional study of consecutive diagnostic gastroscopies in adults was designed. Systematic gastric biopsies were taken. The updated Sydney guidelines were used for histological grading of GA and IM. Higher GC risk was defined as OLGIM III\u2013IV and advanced GA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The OLGIMA stage was assessed based on the most severe GA and\/or IM findings in both antrum and corpus. We included 998 patients (median age 57; 64% women; 35%\n                      <jats:italic>Helicobacter pylori<\/jats:italic>\n                      infection). Thirty\u2010nine (3.9%) patients had higher GC risk: 17 (1.7%) with OLGIM III\u2013IV; 12 (1.2%) with advanced GA, and 10 (1%) meeting both criteria. Among OLGIM 0\u2010II, 12 (1.2%) patients had advanced GA. The OLGIMA system upstaged 39 (3.9%) patients to III\u2013IV, being more sensitive than OLGIM.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The new OLGIMA system identifies patients at higher GC risk (OLGIMA III\u2013IV), encompassing all OLGIM III\u2013IV patients, and upstaging those OLGIM 0\u2013II with advanced GA. This approach addresses the OLGA and OLGIM limitations by integrating GA and IM severity as recommended by the Updated Sydney consensus.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/his.70042","type":"journal-article","created":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T10:38:08Z","timestamp":1764153488000},"page":"911-921","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The\n                    <scp>OLGIMA<\/scp>\n                    system for gastric cancer risk assessment. A\u00a0useful method based on the histological Sydney consensus"],"prefix":"10.1111","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5798-5491","authenticated-orcid":false,"given":"Pedro Genaro","family":"Delgado Guillena","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Hospital de M\u00e9rida  Badajoz Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3063-0110","authenticated-orcid":false,"given":"Miriam","family":"Cuatrecasas","sequence":"additional","affiliation":[{"name":"Department of Pathology Hospital Cl\u00ednic  Barcelona Spain"},{"name":"Fundaci\u00f3 de Recerca Cl\u00ednic Barcelona\u2010Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (FRCB\u2010IDIBAPS)  Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD)  Madrid Spain"},{"name":"Facultat de Medicina i Ci\u00e8ncies de la Salud Universitat de Barcelona (UB)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1836-1966","authenticated-orcid":false,"given":"Sheyla","family":"Montori","sequence":"additional","affiliation":[{"name":"Gastroenterology Research Unit, Navarrabiomed, Hospital Universitario de Navarra (HUN) Universidad P\u00fablica de Navarra (UPNA), IdiSNA  Pamplona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8561-4794","authenticated-orcid":false,"given":"Nayra","family":"Felipez Varela","sequence":"additional","affiliation":[{"name":"Gastroenterology Research Unit, Navarrabiomed, Hospital Universitario de Navarra (HUN) Universidad P\u00fablica de Navarra (UPNA), IdiSNA  Pamplona 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Spain"},{"name":"Fundaci\u00f3 de Recerca Cl\u00ednic Barcelona\u2010Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (FRCB\u2010IDIBAPS)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6186-517X","authenticated-orcid":false,"given":"Pablo","family":"Florez\u2010Diez","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias, Servicio Aparato Digestivo Hospital Universitario Central de Asturias  Oviedo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9587-9278","authenticated-orcid":false,"given":"Eva","family":"Barreiro\u2010Alonso","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias, Servicio Aparato Digestivo Hospital Universitario Central de Asturias  Oviedo 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