{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T23:39:52Z","timestamp":1791589192235,"version":"4.3.4"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T00:00:00Z","timestamp":1764115200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T00:00:00Z","timestamp":1764115200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>\n                      Nodular fasciitis (NF), myositis ossificans\/fibro\u2010osseous pseudotumor of the digits (MO\/FP) and aneurysmal bone cyst (ABC) are grouped under the category of \u2018\n                      <jats:italic>USP6<\/jats:italic>\n                      \u2010associated neoplasms\u2019 (UANs) due to their shared characteristic of an underlying\n                      <jats:italic>USP6<\/jats:italic>\n                      rearrangement.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      Our aim in this study is to investigate the diversity of\n                      <jats:italic>USP6<\/jats:italic>\n                      rearrangements in UANs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>\n                      We performed a clinicopathological and molecular investigation using targeted RNA sequencing on 124 cases of NF, 19 cases of MO\/PF and 32 cases of ABC. Additionally, NF cases were scored for the presence of typical morphological features to assess their correlation with the detected\n                      <jats:italic>USP6<\/jats:italic>\n                      fusion partner.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In 85.4% of NF cases (88\/103), we identified a\n                      <jats:italic>USP6<\/jats:italic>\n                      rearrangement, with 46.6% exhibiting the classic\n                      <jats:italic>MYH9::USP6<\/jats:italic>\n                      fusion and 53.4% displaying non\u2010\n                      <jats:italic>MYH9::USP6<\/jats:italic>\n                      fusions. Notably, classic histological features of NF strongly correlated with the presence of the\n                      <jats:italic>MYH9::USP6<\/jats:italic>\n                      fusion, while specific NF locations (e.g. intramuscular, intra\u2010articular and intradermal) were significantly associated with non\u2010\n                      <jats:italic>MYH9<\/jats:italic>\n                      fusions. This study identified 22 novel\n                      <jats:italic>USP6<\/jats:italic>\n                      fusion partners, demonstrating the fusion diversity within UANs. Additionally, there was minimal overlap in\n                      <jats:italic>USP6<\/jats:italic>\n                      fusion partners between different UAN types.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      A significant entity\u2010 and location\u2010specific\n                      <jats:italic>USP6<\/jats:italic>\n                      fusion partner diversity was revealed among the UAN members. This supports the hypothesis that this diversity may be linked to the cell of origin. Additionally, molecular analysis can be valuable in diagnosing non\u2010classical NF.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/his.70057","type":"journal-article","created":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T10:21:08Z","timestamp":1764152468000},"page":"898-910","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A morphomolecular study of 175 \u2018\n                    <scp>\n                      <i>USP6<\/i>\n                    <\/scp>\n                    \u2010associated neoplasms\u2019: The\n                    <scp>\n                      <i>USP6<\/i>\n                    <\/scp>\n                    fusion partner strongly depends on morphology and location"],"prefix":"10.1111","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0876-3398","authenticated-orcid":false,"given":"Fleur","family":"Cordier","sequence":"first","affiliation":[{"name":"Department of Pathology Ghent University Hospital, Ghent University  Ghent Belgium"},{"name":"CRIG, Cancer Research Institute Ghent Ghent University Hospital, Ghent University  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8175-2930","authenticated-orcid":false,"given":"Jo","family":"Van Dorpe","sequence":"additional","affiliation":[{"name":"Department of Pathology Ghent University Hospital, Ghent University  Ghent Belgium"},{"name":"CRIG, Cancer Research Institute Ghent Ghent University Hospital, Ghent University  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2244-5839","authenticated-orcid":false,"given":"Raf","family":"Sciot","sequence":"additional","affiliation":[{"name":"Department of Imaging and Pathology KU Leuven, University Hospitals Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0315-4307","authenticated-orcid":false,"given":"Uta","family":"Flucke","sequence":"additional","affiliation":[{"name":"Department of Pathology Radboud University Medical Center  Nijmegen Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joost","family":"Van Gorp","sequence":"additional","affiliation":[{"name":"Department of Pathology St Antonius Hospital  Nieuwegein The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8183-2105","authenticated-orcid":false,"given":"Maria","family":"Debiec\u2010Rychter","sequence":"additional","affiliation":[{"name":"Department of Human Genetics University Hospitals Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Van Belle","sequence":"additional","affiliation":[{"name":"Department of Pathology Radboud University Medical Center  Nijmegen Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4602-4580","authenticated-orcid":false,"given":"Siebe","family":"Loontiens","sequence":"additional","affiliation":[{"name":"CRIG, Cancer Research Institute Ghent Ghent University Hospital, Ghent University  Ghent Belgium"},{"name":"Molecular Diagnostics Ghent University Hospital (MDG) Ghent University Hospital, Ghent University  Ghent Belgium"},{"name":"Department of Biomolecular Medicine Ghent University  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1916-2769","authenticated-orcid":false,"given":"Joni","family":"Van der Meulen","sequence":"additional","affiliation":[{"name":"CRIG, Cancer Research Institute Ghent Ghent University Hospital, Ghent University  Ghent Belgium"},{"name":"Molecular Diagnostics Ghent University Hospital (MDG) Ghent University Hospital, Ghent University  Ghent Belgium"},{"name":"Department of Biomolecular Medicine Ghent University  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bram","family":"Van Gaever","sequence":"additional","affiliation":[{"name":"Department of Pathology Ghent University Hospital, Ghent University  Ghent Belgium"},{"name":"CRIG, Cancer Research Institute Ghent Ghent University Hospital, Ghent University  Ghent Belgium"},{"name":"Center for Molecular Genetics Ghent Ghent University Hospital, Ghent 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Hospital, Ghent University  Ghent Belgium"},{"name":"Research Foundation Flanders (FWO)  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,26]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2018.01.006"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2013.03.005"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp-2023-208896"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/1066896920938878"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-03-2827"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1208506"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63432-3"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2010.116"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2011.118"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.12828"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19820415)49:8<1668::AID-CNCR2820490823>3.0.CO;2-9"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.3109\/00313028409059097"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199110000-00004"},{"key":"e_1_2_12_15_1","first-page":"533","article-title":"Chromosomal 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