{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T14:38:03Z","timestamp":1791556683895,"version":"4.3.4"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T00:00:00Z","timestamp":1766361600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T00:00:00Z","timestamp":1766361600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background and objectives<\/jats:title>\n                    <jats:p>\n                      <jats:italic>GREB1<\/jats:italic>\n                      \u2010rearranged uterine tumours encompass a group of uterine mesenchymal tumours with varied histologic appearances. The fusion partners to\n                      <jats:italic>GREB1<\/jats:italic>\n                      include\n                      <jats:italic>NCOA1\u20103, SS18<\/jats:italic>\n                      and\n                      <jats:italic>NR4A3<\/jats:italic>\n                      . Given that some\n                      <jats:italic>GREB1<\/jats:italic>\n                      \u2010rearranged uterine tumours exhibit histologic features of uterine tumours resembling ovarian sex cord tumour (UTROSCT), there is a general belief that\n                      <jats:italic>GREB1<\/jats:italic>\n                      \u2010rearranged uterine mesenchymal tumours are part of the UTROSCT family.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this study, we applied global DNA methylation and copy number analyses to a series of 10\n                      <jats:italic>GREB1\u2010<\/jats:italic>\n                      rearranged uterine tumours and 21 classic UTROSCTs (7 of which were molecularly confirmed to harbour\n                      <jats:italic>ESR1::NCOA2\/3<\/jats:italic>\n                      fusions).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We found that\n                      <jats:italic>GREB1<\/jats:italic>\n                      \u2010rearranged uterine tumors show an overlap in their global methylation profiles with UTROSCT, including\n                      <jats:italic>ESR1::NCOA2\/3<\/jats:italic>\n                      positive cases. Together, these tumours form a DNA methylation cluster separate from uterine smooth muscle tumours (leiomyomas and leiomyosarcomas), endometrial stromal sarcomas (low\u2010grade and high\u2010grade), embryonal rhabdomyosarcoma and SMARCA4\u2010deficient uterine sarcomas. However, despite their epigenetic similarity, there were two notable differences. First,\n                      <jats:italic>GREB1<\/jats:italic>\n                      \u2010rearranged uterine tumours as a group displayed a greater degree of genomic complexity with more extensive copy number alterations than conventional UTROSCTs, including those harbouring\n                      <jats:italic>ESR1::NCOA2\/3<\/jats:italic>\n                      . Second,\n                      <jats:italic>GREB1<\/jats:italic>\n                      \u2010rearranged uterine tumours frequently lacked overt sex cord morphology: while all 7\n                      <jats:italic>ESR1::NCOA2\/3<\/jats:italic>\n                      UTROSCTs demonstrated corded, nested, trabecular and\/or tubular\/sertoliform patterns, only 1\n                      <jats:italic>GREB1<\/jats:italic>\n                      \u2010rearranged uterine tumour displayed a prominent trabecular pattern, with the remaining cases showing exclusively or predominantly diffuse\/solid growth.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Overall, our findings confirm that\n                      <jats:italic>GREB1<\/jats:italic>\n                      \u2010rearranged uterine tumours are part of the UTROSCT spectrum, though they frequently exhibit a more diffuse growth pattern and a higher degree of genomic instability.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/his.70075","type":"journal-article","created":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T10:00:03Z","timestamp":1766397603000},"page":"1084-1093","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["<scp>\n                      <i>GREB1<\/i>\n                    <\/scp>\n                    \u2010rearranged uterine tumour shares a common\n                    <scp>DNA<\/scp>\n                    methylation signature with\n                    <scp>\n                      <i>ESR1<\/i>\n                    <\/scp>\n                    \u2010rearranged\n                    <scp>UTROSCT<\/scp>"],"prefix":"10.1111","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2094-1222","authenticated-orcid":false,"given":"Cheng\u2010Han","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine and Pathology University of Alberta  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7470-8319","authenticated-orcid":false,"given":"Yow\u2010Shan","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Family Medicine Cathay General Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8155-7131","authenticated-orcid":false,"given":"Jennifer A","family":"Bennett","sequence":"additional","affiliation":[{"name":"University of Chicago Medical Center  Chicago Illinois 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Gung University College of Medicine  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6615-2037","authenticated-orcid":false,"given":"Martin","family":"K\u00f6bel","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of Calgary  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8591-2237","authenticated-orcid":false,"given":"Mark","family":"Sementsov","sequence":"additional","affiliation":[{"name":"Institute of Pathology, Heidelberg University Hospital  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2269-6216","authenticated-orcid":false,"given":"Brendan C","family":"Dickson","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Sinai Health System and University of Toronto  Toronto Ontario 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