{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:02:19Z","timestamp":1791234139565,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T00:00:00Z","timestamp":1766880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T00:00:00Z","timestamp":1766880000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study aimed to investigate the clinical and histopathological features of sebaceous tumours of the genital area and their association with human papilloma virus (HPV) infection and mismatch repair (MMR) protein deficiency.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p>Ethical approval was obtained, haematoxylin and eosin (H&amp;E)\u2010stained sections were reviewed, and immunohistochemistry (IHC) for p16, p53, mismatch repair proteins and HPV RNA\u2010in\u2010situ hybridization or HPV genotyping were performed. Clinical follow\u2010up was retrieved from patient records.<\/jats:p>\n                    <jats:p>Six tumours presented in adulthood (median: 69; range: 48\u201373\u2009years; M:F\u2009=\u20092:1) and were located on the penis, mons pubis and labia majora (median size 1.3\u2009cm). There were four sebaceous carcinomas, one sebaceoma and one sebaceous adenoma. Three of four sebaceous carcinomas showing an overlying in\u2010situ component were positive for high\u2010risk HPV\u2010ISH or subtypes, p16 block positive and p53 wild\u2010type by IHC. The sebaceous adenoma showed loss of mismatch repair proteins and was associated with Muir\u2013Torre syndrome (MTS), while all remaining tumours showed intact MMR protein staining, were negative for HPV, and p16 and p53 wildtype by IHC. The patient with MTS died of oesophageal adenocarcinoma; all other patients were alive without recurrences (median follow\u2010up: 16\u2009months, range 7\u201360\u2009months).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In conclusion, the study emphasizes a pathogenetic role of HPV in genital sebaceous carcinomas that typically present with an in\u2010situ component.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/his.70078","type":"journal-article","created":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T01:18:24Z","timestamp":1766971104000},"page":"1221-1228","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Human papilloma virus infection and mismatch repair protein expression in sebaceous neoplasms of the genital area"],"prefix":"10.1111","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0754-2393","authenticated-orcid":false,"given":"Katharina","family":"Wiedemeyer","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of Calgary  Calgary Alberta Canada"},{"name":"Department of Pathology University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zainab","family":"Al\u2010Shamma","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of Calgary  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6615-2037","authenticated-orcid":false,"given":"Martin","family":"K\u00f6bel","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of Calgary  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4321-5250","authenticated-orcid":false,"given":"Ingrid","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Experimental Cancer Genetics Wellcome Sanger Institute, Wellcome Genome Campus  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0802-2883","authenticated-orcid":false,"given":"Paul W.","family":"Harms","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0089-0352","authenticated-orcid":false,"given":"Thomas","family":"Brenn","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of Calgary  Calgary Alberta Canada"},{"name":"Department of Pathology University of Michigan  Ann Arbor Michigan 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