{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:52:08Z","timestamp":1787014328664,"version":"build-2736575974"},"reference-count":36,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T00:00:00Z","timestamp":1766880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T00:00:00Z","timestamp":1766880000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The latest WHO edition proposed using a cut\u2010off of \u22655% high\u2010grade component (%HGc) as a criterion to label non\u2010invasive papillary urothelial carcinomas as high\u2010grade (pTaHG). It also suggested that tumours with minor high\u2010grade component behave more indolently and are better labelled as mixed low\u2010 and high\u2010grade papillary carcinomas.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p>\n                      We investigated the prognostic value of %HGc along with other clinical and morphological parameters. 130 pTaHGs and 96 pTaLGs were included. 9% and 12% of pTaHGs had \u22645% and \u226410% HGc, respectively. Anaplasia was present in six cases (5%), necrosis in 18 cases (14%) and CIS in 5 cases (4%). On average, the highest mitotic count per 1 HPF was 2.4 (range\u2009=\u20090\u201318), and the mean number of mitoses per 10 HPF was 9 (range: 0\u201393). The mean tumour diameter was 2.1\u2009cm. Tumour multifocality was observed in 32 cases (25%). Among the histological parameters, only mitotic activity showed a correlation with the %HGc (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). While recurrence was not significantly different between pTaLGs and pTaHGs (25% vs 35%;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.09), stage progression was significantly different (0% vs 8%;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.005). The two parameters that were associated with recurrence in pTaHGs were tumour multifocality and BCG therapy, while none was associated with progression. %HGc \u22645% and\u2009\u2264\u200910% did not correlate with lower rates of recurrence nor progression.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Those findings suggest that pTaHGs with minor HGc do not exhibit more indolent behaviour and should not be approached similar to pTaLGs. [Correction added on 13 April 2026, after first online publication: This version changes the preceding sentence from \u201cshould be approached\u201d to \u201cshould not be approached\u201d.]<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/his.70086","type":"journal-article","created":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T01:26:39Z","timestamp":1766971599000},"page":"1430-1442","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A minor high\u2010grade component in non\u2010invasive papillary urothelial carcinoma is not associated with a more indolent behaviour"],"prefix":"10.1111","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1579-1680","authenticated-orcid":false,"given":"Mina S.","family":"Farag","sequence":"first","affiliation":[{"name":"Department of Pathology McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neda","family":"Oghbaei","sequence":"additional","affiliation":[{"name":"Research Institute McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6479-8854","authenticated-orcid":false,"given":"Jaffar","family":"Hussain","sequence":"additional","affiliation":[{"name":"Department of Urology McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0110-0727","authenticated-orcid":false,"given":"Andr\u00e9","family":"Lametti","sequence":"additional","affiliation":[{"name":"Department of Pathology McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8350-0531","authenticated-orcid":false,"given":"Wassim","family":"Kassouf","sequence":"additional","affiliation":[{"name":"Department of Urology McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7589-0453","authenticated-orcid":false,"given":"Fadi","family":"Brimo","sequence":"additional","affiliation":[{"name":"Department of Pathology McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,28]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"98","article-title":"Carcinoma of the urinary bladder: a review of its diverse morphology","volume":"14","author":"Eble JN","year":"1997","journal-title":"Semin. 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