{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T11:17:02Z","timestamp":1775474222620,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Scarce literature exists regarding the spectrum of vascular neoplasms of the distal female genital tract. Herein, we describe the clinicopathologic features of a cohort of intermediate to malignant endothelial neoplasms of the vulva and vagina.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>\n                      Specimens were identified retrospectively from in\u2010house and consultation files at our institution. Clinicopathologic data was obtained from review of the chart and available histologic material. Nineteen cases were identified in total. Kaposi sarcoma (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20092) was of the enigmatic \u2018sporadic\u2019 form in elderly non\u2010\n                      <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\n                      females. Kaposiform haemangioendothelioma (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20091) presented at an older (rather than paediatric) age and was negative for\n                      <jats:styled-content style=\"fixed-case\">HHV<\/jats:styled-content>\n                      \u20108 by\n                      <jats:styled-content style=\"fixed-case\">IHC<\/jats:styled-content>\n                      ; both Kaposi sarcomas were positive. Pseudomyogenic haemangioendothelioma (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20092) presented in elderly females (rather than young males) with positivity for both\n                      <jats:styled-content style=\"fixed-case\">FOSB<\/jats:styled-content>\n                      and\u00a0\n                      <jats:styled-content style=\"fixed-case\">AE1<\/jats:styled-content>\n                      \/\n                      <jats:styled-content style=\"fixed-case\">AE3<\/jats:styled-content>\n                      . Epithelioid haemangioendothelioma (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20098), showed variably well\u2010developed chondromyxoid matrix and consistent positivity for\n                      <jats:styled-content style=\"fixed-case\">CAMTA1 IHC<\/jats:styled-content>\n                      . Angiosarcomas were disproportionately of the epithelioid subtype, with high\u2010grade cytologic atypia, destructive infiltration and rare\n                      <jats:styled-content style=\"fixed-case\">EMA<\/jats:styled-content>\n                      positivity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>While many morphologic features of vascular lesions at this site are shared with those of extra\u2010genital soft tissues, pathologists must be aware that these tumours may occur in the vulvovaginal area and display unconventional clinical profiles. As such, a broad differential for epithelioid and spindle cell neoplasms at this site is prudent.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/his.70094","type":"journal-article","created":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T06:55:26Z","timestamp":1769669726000},"page":"1142-1153","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Malignant vascular neoplasms of the distal female genital tract: a series of 19 cases emphasizing unusual features and diagnostic challenges"],"prefix":"10.1111","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3088-3946","authenticated-orcid":false,"given":"Aarti E","family":"Sharma","sequence":"first","affiliation":[{"name":"Department of Pathology, Brigham and Women's Hospital Harvard Medical School  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8696-7666","authenticated-orcid":false,"given":"Nicolas","family":"Wyvekens","sequence":"additional","affiliation":[{"name":"Department of Pathology, Brigham and Women's Hospital Harvard Medical School  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1802-5639","authenticated-orcid":false,"given":"Grace","family":"Neville","sequence":"additional","affiliation":[{"name":"Department of Pathology, Brigham and Women's Hospital Harvard Medical School  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1420-7291","authenticated-orcid":false,"given":"Carlos","family":"Parra\u2010Herr\u00e1n","sequence":"additional","affiliation":[{"name":"Department of Pathology, Brigham and Women's Hospital Harvard Medical School  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6475-8345","authenticated-orcid":false,"given":"Jason L","family":"Hornick","sequence":"additional","affiliation":[{"name":"Department of Pathology, Brigham and Women's Hospital Harvard Medical School  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher D M","family":"Fletcher","sequence":"additional","affiliation":[{"name":"Department of Pathology, Brigham and Women's Hospital Harvard Medical School  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marisa R","family":"Nucci","sequence":"additional","affiliation":[{"name":"Department of Pathology, Brigham and Women's Hospital Harvard Medical School  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,28]]},"reference":[{"key":"e_1_2_11_2_1","volume-title":"Soft tissue and bone tumours","author":"WHO Classification of Tumours Editorial Board","year":"2020"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2013.176"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2024.104268"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAP.0000000000000284"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001552"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001906"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181cf7fc1"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0000000000000472"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001829"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.13430"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001538"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.SMJ.0000157557.92795.18"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajd.13587"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2015.27.3.336"},{"key":"e_1_2_11_16_1","first-page":"227","article-title":"Massive vulval Kaposi's sarcoma in pregnancy: case report","volume":"9","author":"Ngwenya S","year":"2016","journal-title":"Int. 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