{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T11:51:56Z","timestamp":1778500316640,"version":"3.51.4"},"reference-count":53,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T00:00:00Z","timestamp":1768435200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T00:00:00Z","timestamp":1768435200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Cutaneous plasmablastic lymphoma (cPBL) is a rare and aggressive neoplasm that presents as skin nodules. Despite occurring in ~5% of PBL cases, the World Health Organization (WHO) does not distinguish primary cutaneous PBL (pcPBL) from secondary cutaneous PBL (scPBL), and their clinical differences remain poorly defined. To determine whether pcPBL represents a distinct clinical entity, we compare the clinicopathologic features, immunohistochemical profiles, and survival outcomes of pcPBL and scPBL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>\n                      Retrospective comparative study analysing 40 cases of cPBL (6 newly identified institutional cases and 34 cases from the literature), categorized as pcPBL (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200925; no extracutaneous disease at diagnosis) or scPBL (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200915; concurrent extracutaneous disease). Patients with pcPBL were older than those with scPBL (median 62 vs. 43\u2009years; Mann\u2013Whitney\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.018). Leg involvement was significantly associated with pcPBL (OR\u2009=\u20096.22; 95% CI: 1.21\u201331.9;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.031). Disease\u2010specific survival (DSS) analysis included 17 evaluable cases (pcPBL\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200911; scPBL\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20096). Median DSS was 42.0\u2009months in pcPBL and 8.0\u2009months in scPBL (log\u2010rank\n                      <jats:italic>\u03c7<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20093.98; p\u2009=\u20090.046). Median follow\u2010up (reverse Kaplan\u2013Meier) was 20.0\u2009months in pcPBL and not reached in scPBL. Cox models were directionally consistent but underpowered.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this pooled analysis, cases presenting with primary cutaneous involvement tended to occur in older patients and more often involved the legs. However, these observations should be interpreted cautiously given small numbers and heterogeneity of the available data. Within pcPBL, EBV positivity correlated with better survival. These hypothesis\u2010generating findings provide a basis for prospective, multi\u2010centre studies to clarify classification, staging implications, and management of this rare lymphoma.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/his.70095","type":"journal-article","created":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T11:27:34Z","timestamp":1768476454000},"page":"1154-1166","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Cutaneous plasmablastic lymphoma: retrospective comparative study of primary and secondary skin involvement"],"prefix":"10.1111","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-2792-3955","authenticated-orcid":false,"given":"Federico","family":"Repetto","sequence":"first","affiliation":[{"name":"Department of Pathology Massachusetts General Hospital and Harvard Medical School  Boston MA USA"},{"name":"Department of Pathology Brigham and Women's Hospital and Harvard Medical School  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9490-8583","authenticated-orcid":false,"given":"Kristine M","family":"Cornejo","sequence":"additional","affiliation":[{"name":"Department of Pathology Massachusetts General Hospital and Harvard Medical School  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"O'Donnell","sequence":"additional","affiliation":[{"name":"Department of Pathology UMass Chan Medical School  Worcester MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer P","family":"Toyohara","sequence":"additional","affiliation":[{"name":"Department of Dermatology Massachusetts General Hospital and Harvard Medical School  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith A","family":"Ferry","sequence":"additional","affiliation":[{"name":"Department of Pathology Massachusetts General Hospital and Harvard Medical School  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4003-7193","authenticated-orcid":false,"given":"Rosalynn M","family":"Nazarian","sequence":"additional","affiliation":[{"name":"Department of Pathology Massachusetts General Hospital and Harvard Medical School  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,15]]},"reference":[{"key":"e_1_2_11_2_1","volume-title":"Haematolymphoid tumours","author":"WHO Classification of Tumours Editorial Board","year":"2024"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V89.4.1413"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1354604"},{"key":"e_1_2_11_5_1","article-title":"EBV infection determines the immune hallmarks of plasmablastic lymphoma","volume":"7","author":"Gravelle P","year":"2018","journal-title":"Onco. 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