{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:47:50Z","timestamp":1792000070739,"version":"4.4.0"},"reference-count":27,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T00:00:00Z","timestamp":1767916800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T00:00:00Z","timestamp":1767916800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Epstein\u2013Barr virus (EBV)\u2010positive inflammatory follicular dendritic cell sarcoma (EBV+ IFDCS) is a rare, indolent malignant neoplasm. Due to its rarity, a comprehensive assessment of its immunophenotypic spectrum and molecular analysis is still lacking. This study aimed to characterize the immunophenotypic and genetic alterations of EBV+ IFDCS to improve understanding of its cell of origin and molecular pathogenesis and to identify potential therapeutic targets.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>\n                      Immunohistochemical staining for a panel of follicular dendritic cell (FDC) and fibroblastic reticular cell (FRC) lineage markers, along with targeted next\u2010generation sequencing, was performed. Nineteen cases of EBV+ IFDCS were classified into four immunophenotypes: nine FDC, two FRC, three biphasic and five null phenotypes. Morphologically, cases with a null phenotype more frequently exhibited a lymphoma\u2010like growth pattern (4\/5, 80%) compared with those with a definite FDC and\/or FRC phenotype (1\/14, 7.1%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.006). Moreover, a scattered distribution of neoplastic cells was more commonly observed in null phenotype cases (4\/5, 80%) than in FDC and\/or FRC phenotype cases (3\/14, 21.4%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.038). Targeted sequencing revealed somatic variants in chromatin modifier\u2010related genes in 60.0% (9\/15), homologous recombination repair (HRR)\u2010related genes in 53.3% (8\/15) and Hippo pathway\u2010related\u00a0genes (\n                      <jats:italic>FAT2<\/jats:italic>\n                      and\n                      <jats:italic>FAT1<\/jats:italic>\n                      ) in 26.7% (4\/15) of cases.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings demonstrate the wide morphological and immunophenotypic spectrum of EBV+ IFDCS. Furthermore, variants in chromatin modifier and HRR\u2010related genes may participate in its pathogenesis, and PARP inhibition may represent a potential therapeutic strategy for patients with unresectable disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/his.70097","type":"journal-article","created":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T09:45:33Z","timestamp":1767951933000},"page":"1405-1418","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Immunophenotypic spectrum and mutational landscape of\n                    <scp>EBV<\/scp>\n                    \u2010positive inflammatory follicular dendritic cell sarcoma"],"prefix":"10.1111","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4842-5617","authenticated-orcid":false,"given":"Jian\u2010Chao","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Pathology Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital  Fuzhou China"},{"name":"Department of Pathology, The School of Basic Medical Sciences Fujian Medical University  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0692-5162","authenticated-orcid":false,"given":"Chen","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang\u2010Fang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pathology Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010Fang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital  Fuzhou China"},{"name":"Department of Pathology, The School of Basic Medical Sciences Fujian Medical University  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi\u2010Qing","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Pathology Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Jiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu\u2010Lin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pathology, The School of Basic Medical Sciences Fujian Medical University  Fuzhou China"},{"name":"Department of Pathology Mengchao Hepatobiliary Hospital of Fujian Medical University  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mu\u2010Sheng","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pathology Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital  Fuzhou China"},{"name":"Department of Pathology Chongqing University Cancer Hospital  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010Hua","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Pathology Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010Yan","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Pathology Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital  Fuzhou 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2540-8232","authenticated-orcid":false,"given":"Gang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pathology Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital  Fuzhou China"},{"name":"Department of Pathology, The School of Basic Medical Sciences Fujian Medical University  Fuzhou China"},{"name":"Fujian Key Laboratory of Advanced Technology for Cancer Screening and Early Diagnosis Fujian Cancer Hospital  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,9]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"791","volume-title":"World Health Organization classification of Haematolymphoid Tumours, 5th edition","author":"Li 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follicular\/fibroblastic dendritic cell sarcoma: a case report and review of literature","volume":"37","author":"Morales\u2010Vargas B","year":"2021","journal-title":"Turk Patoloji 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