{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T01:56:50Z","timestamp":1785895010395,"version":"3.56.0"},"reference-count":89,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T00:00:00Z","timestamp":1769644800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T00:00:00Z","timestamp":1769644800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:p>\n                    Phyllodes tumours of the breast present challenges in their diagnosis, classification and management. Further understanding of the molecular changes underpinning these tumours may lead to more precise classification and potential treatment options. Similar to fibroadenomas,\n                    <jats:italic>MED12<\/jats:italic>\n                    is the most frequently mutated gene in phyllodes tumour. However, in addition, there is a spectrum of molecular alterations from benign to malignant phyllodes tumours with increasing genomic complexity, high level copy number alterations and aberrations of cancer driver genes in malignant phyllodes tumours. This review summarizes the molecular pathology of phyllodes tumours, the use of these data in developing a model of phyllodes tumour pathogenesis, and how molecular pathology might be applied to aid diagnosis and guide treatment in this rare tumour type.\n                  <\/jats:p>","DOI":"10.1111\/his.70098","type":"journal-article","created":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T03:43:53Z","timestamp":1769744633000},"page":"1115-1125","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Molecular pathology of phyllodes tumours of the breast\u2014much more than\n                    <i>MED12<\/i>"],"prefix":"10.1111","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3466-7431","authenticated-orcid":false,"given":"Jia\u2010Min B","family":"Pang","sequence":"first","affiliation":[{"name":"Peter MacCallum Cancer Centre  Melbourne Victoria Australia"},{"name":"Sir Peter MacCallum Department of Oncology  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5681-2022","authenticated-orcid":false,"given":"Kylie L","family":"Gorringe","sequence":"additional","affiliation":[{"name":"Peter MacCallum Cancer Centre  Melbourne Victoria Australia"},{"name":"Sir Peter MacCallum Department of Oncology  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1052-8605","authenticated-orcid":false,"given":"Puay Hoon","family":"Tan","sequence":"additional","affiliation":[{"name":"Luma Medical Centre, KK Women's and Children's Hospital and Yong Loo Lin School of Medicine National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7648-8896","authenticated-orcid":false,"given":"Stephen B","family":"Fox","sequence":"additional","affiliation":[{"name":"Peter MacCallum Cancer Centre  Melbourne Victoria Australia"},{"name":"Sir Peter MacCallum Department of Oncology  Melbourne Victoria Australia"},{"name":"Collaborative Centre for Cancer Genomic Medicine The University of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,29]]},"reference":[{"key":"e_1_2_11_2_1","volume-title":"Breast Tumours","author":"WHO Classification of Tumours Editorial Board","year":"2019"},{"key":"e_1_2_11_3_1","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/his.12876","article-title":"Phyllodes tumours of the breast: a consensus review","volume":"68","author":"Tan BY","year":"2016","journal-title":"Histopathology"},{"key":"e_1_2_11_4_1","unstructured":"Cancer Data in Australia.Welfare AIoHa Australia 2024.2024."},{"key":"e_1_2_11_5_1","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.ejca.2022.06.036","article-title":"Incidence and outcome of breast sarcomas in England (2013\u20102018): an analysis from the National Cancer Registration and analysis service","volume":"174","author":"Ahmed M","year":"2022","journal-title":"Eur. 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