{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T02:09:48Z","timestamp":1777860588466,"version":"3.51.4"},"reference-count":29,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T00:00:00Z","timestamp":1770940800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T00:00:00Z","timestamp":1770940800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Epstein\u2013Barr virus (EBV)\u2010positive small cell neuroendocrine carcinoma of the nasopharynx (SCNEC\u2010nasopharynx) is exceptionally rare and aggressive, with poorly characterized molecular features.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Clinicopathological, immunohistochemical (synaptophysin, INSM1, chromogranin A, CK\u2010pan, EGFR, NUT, INI1), and molecular profiles of 15 EBV\u2010positive SCNEC\u2010nasopharynx cases (2012\u20132025) were analysed. EBV status was confirmed by EBER\u2010ISH. Exploratory next\u2010generation sequencing compared nine SCNEC with five EBV\u2010positive nasopharyngeal non\u2010keratinizing carcinomas (NKUC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Patients (median age 51; male:female\u2009=\u20092:1) presented with advanced\u2010stage disease and cervical lymphadenopathy. Histology showed solid nests of small cells with high\u2010grade features. All tumours were diffusely positive for synaptophysin and EBER, showed perinuclear dot\u2010like CK\u2010pan staining, and were negative for squamous markers and EGFR. NUT was negative and INI1 retained. Comparative genomics revealed greater mutational burden and unique alterations enriched in cell cycle\/DNA damage pathways in SCNEC versus NKUC. After multimodal therapy, median overall survival was 33\u2009months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This largest integrated study defines the distinct clinicopathological and molecular profile of EBV\u2010positive SCNEC\u2010nasopharynx. The identified diagnostic immunophenotype and potential oncogenic pathways provide a foundation for precise diagnosis and future targeted therapy development.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/his.70118","type":"journal-article","created":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T02:34:46Z","timestamp":1771036486000},"page":"1419-1429","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinicopathological and molecular genetic characteristics of Epstein\u2013Barr virus\u2010positive small cell neuroendocrine carcinoma of the nasopharynx"],"prefix":"10.1111","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1109-1177","authenticated-orcid":false,"given":"Lu","family":"Jian\u2010Ping","sequence":"first","affiliation":[{"name":"Department of Pathology Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital  Fuzhou 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