{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T22:40:54Z","timestamp":1785883254356,"version":"3.56.0"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:00:00Z","timestamp":1772064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:00:00Z","timestamp":1772064000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Plaque\u2010like CD34\u2010positive dermal fibroma (PDF), previously termed medallion\u2010like dermal dendrocyte hamartoma, is a rare CD34\u2010positive superficial spindle cell fibroblastic tumour that may closely mimic dermatofibrosarcoma protuberans. Recent studies have identified recurrent kinase gene fusions in a subset of congenital and paediatric CD34\u2010positive plaque\u2010like superficial spindle cell tumours with overlapping clinicopathologic features, highlighting an emerging molecular framework for this group. However, the molecular spectrum of lesions meeting classic histopathologic criteria for PDF remains an area of active investigation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>\n                      Four cases of PDF were identified retrospectively, and histopathologic and immunohistochemical findings were reviewed. RNA\u2010based next\u2010generation sequencing was performed to evaluate for potential oncogenic gene fusions. All cases demonstrated a superficial, dermal\u2010based proliferation of bland spindle cells with a preserved Grenz zone and diffuse CD34 expression, without S100 expression. Two of four cases harboured in\u2010frame\n                      <jats:italic>NTRK3<\/jats:italic>\n                      fusions, including a novel\n                      <jats:italic>SPTBN1::NTRK3<\/jats:italic>\n                      fusion and a\n                      <jats:italic>PPFIBP1::NTRK3<\/jats:italic>\n                      fusion, both retaining the\n                      <jats:italic>NTRK3<\/jats:italic>\n                      tyrosine kinase domain. Available clinical follow\u2010up demonstrated indolent behaviour in all patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      <jats:italic>NTRK3<\/jats:italic>\n                      gene fusions occur in a subset of plaque\u2010like CD34\u2010positive dermal fibromas, providing additional molecular insight into this rare superficial spindle cell lesion. Together with emerging literature, these findings support a role for recurrent kinase gene rearrangements in a subset of CD34\u2010positive plaque\u2010like superficial spindle cell tumours, while underscoring the continued importance of clinicopathologic correlation in defining this evolving spectrum.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/his.70120","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T20:18:30Z","timestamp":1773001110000},"page":"1443-1450","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Identification of\n                    <scp>\n                      <i>NTRK3<\/i>\n                    <\/scp>\n                    fusions in plaque\u2010like\n                    <scp>CD34<\/scp>\n                    \u2010positive dermal fibroma"],"prefix":"10.1111","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8630-8609","authenticated-orcid":false,"given":"Jeffrey M","family":"Cloutier","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Dartmouth Hitchcock Medical Center  Lebanon New Hampshire USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Pathology New York University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3941-3561","authenticated-orcid":false,"given":"Iwei","family":"Yeh","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Pathology University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8916-8966","authenticated-orcid":false,"given":"George","family":"Jour","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Pathology New York University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5762-3490","authenticated-orcid":false,"given":"Gauri","family":"Panse","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Pathology Yale University School of Medicine  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,26]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2003.11.070"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2007.00552.x"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.03.003"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181c7cf11"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08896.x"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.22663"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-018-0089-4"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-025-04088-4"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2025.106011"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-024-03831-7"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-018-2415-0"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.15239"},{"key":"e_1_2_11_14_1","volume-title":"WHO classification of skin tumours","author":"Luzar B","year":"2025"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmoldx.2024.05.013"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-021-00913-8"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cancergen.2021.10.007"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.14842"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.22846"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000675"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.22877"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.22671"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001062"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000911"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.13666"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.70016"},{"key":"e_1_2_11_27_1","first-page":"147","article-title":"NTRK3\u2010rearranged spindle cell neoplasm of the skin: diagnostic pitfalls of an emerging entity, a case report","volume":"34","author":"Coutada A","year":"2025","journal-title":"Acta Dermatovenerol. Alp. Pannonica Adriat."},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000002477"},{"key":"e_1_2_11_29_1","article-title":"Novel ALK fusion, PPFIBP1\u2010ALK, in pancreatic ductal adenocarcinoma responsive to Alectinib and Lorlatinib","volume":"4","author":"Gower A","year":"2020","journal-title":"JCO Precis. 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