{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T15:38:44Z","timestamp":1790091524015,"version":"4.0.1"},"reference-count":12,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T00:00:00Z","timestamp":1770940800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T00:00:00Z","timestamp":1770940800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Human papillomavirus (HPV) is the most common sexually transmitted disease in the United States. HPV\u2010associated invasive anorectal adenocarcinoma has been previously described. In this study, we report the clinicopathological features of three HPV\u2010associated anorectal adenomas.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>\n                      A retrospective review of anorectal adenomas identified 46 in\u2010house cases. Chromogenic\n                      <jats:italic>in situ<\/jats:italic>\n                      hybridization (CISH) for low\u2010 and high\u2010risk HPV subtypes was performed, and high\u2010risk HPV was detected in one (2.1%) case. Additionally, two consultation cases of HPV\u2010positive anorectal adenomas were included, yielding a total of three cases (two females and one male, ages 58\u201363). All three tumours were located in the surgical anal canal and exhibited similar histologic features, characterized by a predominantly villous or villoglandular architecture with slit\u2010like serrations. The tumour cells exhibited eosinophilic to mucinous cytoplasm with apical mucin cups. The nuclei were crowded and oval\u2010 to cigar\u2010shaped. The chromatin was mostly smooth and delicate without prominent nucleoli. Additional immunohistochemistry performed on these HPV\u2010positive adenomas revealed diffuse positivity for p16, CK7 and MUC5AC, with variable CDX2 expression.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>HPV\u2010associated anorectal adenomas are a distinct and rare entity. To the best of our knowledge, this is the first clinicopathological report of well\u2010documented high\u2010risk\u2010HPV\u2010associated anorectal adenomas. Increased awareness of this entity among pathologists will enable larger scale studies to further understand the pathogenesis of HPV\u2010associated anorectal adenocarcinoma.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/his.70121","type":"journal-article","created":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T02:24:16Z","timestamp":1771035856000},"page":"1459-1463","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Human papillomavirus\u2010associated adenoma of the anorectum"],"prefix":"10.1111","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1660-1137","authenticated-orcid":false,"given":"Paula","family":"Toro","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1453-9421","authenticated-orcid":false,"given":"Clifton","family":"Fulmer","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9257-0251","authenticated-orcid":false,"given":"Erica","family":"Savage","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9069-4178","authenticated-orcid":false,"given":"Xuefeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,13]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-019-0437-z"},{"key":"e_1_2_10_3_1","first-page":"184","article-title":"HPV\u2010driven anal neoplasia: review and recent developments","volume":"54","author":"Assarzadegan N","year":"2022","journal-title":"Pathology (Phila.)"},{"key":"e_1_2_10_4_1","volume-title":"Digestive System Tumours. WHO Classification of Tumours Series","author":"WHO Classification of Tumours Editorial Board","year":"2019"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2017-019005"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-018-0049-2"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.4103\/jcrt.JCRT_636_20"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2014.01.019"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000002312"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-005-2928-7"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19990118)80:2<210::AID-IJC9>3.0.CO;2-U"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00795-020-00274-2"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.23748"}],"container-title":["Histopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/his.70121","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/his.70121","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/his.70121","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T01:08:42Z","timestamp":1777511322000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/his.70121"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,13]]},"references-count":12,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1111\/his.70121"],"URL":"https:\/\/doi.org\/10.1111\/his.70121","archive":["Portico"],"relation":{},"ISSN":["0309-0167","1365-2559"],"issn-type":[{"value":"0309-0167","type":"print"},{"value":"1365-2559","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,13]]},"assertion":[{"value":"2025-12-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}