{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T14:23:32Z","timestamp":1780496612000,"version":"3.54.1"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:00:00Z","timestamp":1772064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:00:00Z","timestamp":1772064000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>\n                      Accurate diagnosis of histiocytosis remains challenging due to overlapping morphologic and immunophenotypic features among subtypes, including Langerhans cell histiocytosis (LCH), Erdheim\u2013Chester disease\/xanthogranuloma (ECD\/XG) and Rosai\u2013Dorfman disease (RDD). RDD is a rare disorder characterized by large S100\u2010positive histiocytes with emperipolesis; however, emperipolesis may be difficult to recognize due to abundant admixed inflammatory cells or stromal fibrosis. Moreover, unlike LCH and ECD, RDD does not harbour\n                      <jats:italic>BRAF<\/jats:italic>\n                      V600E mutation, limiting the utility of high\u2010sensitivity molecular analysis and mutant\u2010specific immunohistochemistry for\n                      <jats:italic>BRAF<\/jats:italic>\n                      , which are available in many institutions. We observed the expression of CD71 in histiocytes in RDD. Therefore, we investigated the diagnostic utility of CD71 immunohistochemistry for RDD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>\n                      We retrospectively reviewed electronic medical records to identify the cases of histiocytosis and reactive histiocytic proliferations. Clinical data and molecular results were also reviewed. The cohort comprised 58 cases, including RDD (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200922), LCH (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20096), non\u2010LCH\/ECD\/XG (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200914), histiocytic sarcoma (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20094) and benign reactive cases (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200912). CD71 demonstrated membranous and cytoplasmic staining in all RDD cases (22\/22, 100%). In contrast, lesional cells in LCH were uniformly negative for CD71. Most non\u2010RDD cases lacked CD71 expression, although dim cytoplasmic staining was observed in a subset of cases. Two sarcoidosis cases and one histiocytic sarcoma showed CD71 expression comparable to RDD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>CD71 immunohistochemistry is a sensitive marker for identifying histiocytes in RDD and serves as a useful adjunct in distinguishing RDD from other histiocytic proliferations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/his.70128","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T17:34:46Z","timestamp":1772991286000},"page":"58-68","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>CD71<\/scp>\n                    expression in Rosai\u2013Dorfman disease: a useful adjunct marker in the differential diagnosis of histiocytic proliferations"],"prefix":"10.1111","volume":"89","author":[{"given":"Nurfiza N","family":"Ladak","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Memorial Sloan Kettering Cancer Center  New York New York USA"},{"name":"Department of Laboratory Medicine Southlake Health  Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4048-8376","authenticated-orcid":false,"given":"Kseniya","family":"Petrova\u2010Drus","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2766-243X","authenticated-orcid":false,"given":"Meera R","family":"Hameed","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6576-5256","authenticated-orcid":false,"given":"Ahmet","family":"Dogan","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5456-5961","authenticated-orcid":false,"given":"Eli L","family":"Diamond","sequence":"additional","affiliation":[{"name":"Department of Neurology Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3864-7921","authenticated-orcid":false,"given":"Mariko","family":"Yabe","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,26]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-15-0913"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019003507"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-03-839753"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1275085"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11912-019-0810-6"},{"key":"e_1_2_10_7_1","first-page":"63","article-title":"Sinus histiocytosis with massive lymphadenopathy","volume":"87","author":"Rosai J","year":"1969","journal-title":"Arch. 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