{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T14:23:57Z","timestamp":1780496637777,"version":"3.54.1"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T00:00:00Z","timestamp":1771804800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T00:00:00Z","timestamp":1771804800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Ossifying spindled and epithelioid tumour (OSET) is a recently defined soft tissue neoplasm with characteristic features, including a peripheral shell of bone or pseudocapsule, keratin expression, and indolent behaviour. Here, we present five unique cases of OSET with novel clinical and morphologic features.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>Cases of OSET were collected. Clinicopathologic and molecular features were documented.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Cases of OSET were collected from lesions arising in the extremities of five patients, ranging in age from 8 to 58\u2009years. Histologically, all tumours were well circumscribed and keratin\u2010positive. Three showed a mixed spindle and epithelioid cell morphology, whereas two were composed predominantly of epithelioid cells. Two cases harboured mitotic rates of \u22655 mitotic figures per 10 high\u2010power fields and contained necrosis. While peripheral pseudoencapsulation was consistent, two cases contained minimal peripheral ossification (approximately 5%), and two were entirely non\u2010ossifying. One OSET case showed multifocal disease with synchronous tumours involving the elbow and wrist of the upper extremity; another represented a local recurrence 7\u2009years after resection of the primary tumour; the remaining three patients are disease\u2010free. Next\u2010generation sequencing of tumour RNA revealed an\n                      <jats:italic>SRSF7::NFATC3<\/jats:italic>\n                      fusion in the three cases evaluated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our cohort expands the clinical and morphologic spectrum of this entity to include tumours with increased mitotic activity and necrosis, as well as highlights the first two examples of non\u2010ossifying OSET. Moreover, while confirming the overall indolent behaviour of OSET, we described cases that demonstrate primary multifocal disease and local recurrence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/his.70129","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T16:48:18Z","timestamp":1772988498000},"page":"163-173","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ossifying spindled and epithelioid tumour: Expanding the\u00a0clinical and morphologic spectrum of a recently described\u00a0entity"],"prefix":"10.1111","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2468-2371","authenticated-orcid":false,"given":"Rayan M","family":"Sibira","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine and Pathology University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3724-1145","authenticated-orcid":false,"given":"Benjamin F","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Pathology Valley Children's Healthcare  Madera California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2725-1518","authenticated-orcid":false,"given":"Jessica L","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Indiana University School of Medicine  Indianapolis Indiana USA"},{"name":"Department of Pathology and Laboratory Medicine Oregon Health &amp; Science University  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nada","family":"Mohamed","sequence":"additional","affiliation":[{"name":"Department of Pathology Baylor Scott and White Medical Center  Temple Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riyam","family":"Zreik","sequence":"additional","affiliation":[{"name":"Department of Pathology Baylor Scott and White Medical Center  Temple Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7746-3546","authenticated-orcid":false,"suffix":"Jr.","given":"David J","family":"Papke","sequence":"additional","affiliation":[{"name":"Department of Pathology Brigham and Women's Hospital and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4403-7027","authenticated-orcid":false,"given":"Michael","family":"Michal","sequence":"additional","affiliation":[{"name":"Bioptical Laboratory, Ltd  Pilsen Czech Republic"},{"name":"Department of Pathology, Faculty of Medicine in Pilsen Charles University  Pilsen Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9630-3245","authenticated-orcid":false,"given":"Sintawat","family":"Wangsiricharoen","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Oregon Health &amp; Science University  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3831-7496","authenticated-orcid":false,"given":"Karen J","family":"Fritchie","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,23]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.modpat.2025.100840"},{"key":"e_1_2_11_3_1","unstructured":"Tempus AI Inc.Tempus xR validation summary.2023. 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