{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T09:10:51Z","timestamp":1788858651835,"version":"build-2803163510"},"reference-count":15,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T00:00:00Z","timestamp":1774742400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T00:00:00Z","timestamp":1774742400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Acinar cell carcinoma (ACC) is a lineage\u2010specific carcinoma that occurs nearly exclusively in the pancreas. We report, to our knowledge, the first series of gallbladder carcinoma demonstrating extensive acinar differentiation in the absence of a pancreatic primary.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Three gallbladder carcinomas with extensive acinar differentiation were identified from an international cohort. Clinical, radiologic, macroscopic, histologic, immunophenotypic and molecular features were reviewed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      All tumours lacked an associated pancreatic primary on imaging and clinical evaluation. Two tumours formed well\u2010demarcated mural nodules lacking an exophytic mucosal component, while one tumour was associated with wall thickening. The neoplasms showed mural\u2010based infiltrative lesions composed of nests and acinar structures of cells with amphophilic cytoplasm and prominent nucleoli. One tumour arose in association with high\u2010grade dysplasia and BCL10\u2010positive pyloric\u2010type glands. Two tumours showed pure acinar morphology, while one demonstrated a mixed acinar cell carcinoma and small\u2010cell carcinoma. Immunohistochemically, all tumours showed diffuse expression of trypsin, and two tumours showed diffuse BCL10 positivity. Molecular profiling revealed heterogeneous alterations including\n                      <jats:italic>TP53<\/jats:italic>\n                      mutations in two cases,\n                      <jats:italic>RB1<\/jats:italic>\n                      inactivation in the mixed tumour.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Gallbladder carcinomas may rarely exhibit acinar differentiation that closely mirrors pancreatic ACC. Recognition of this phenotype expands the morphologic repertoire of gallbladder carcinomas.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/his.70145","type":"journal-article","created":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T23:35:15Z","timestamp":1774827315000},"page":"710-715","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Primary gallbladder carcinomas showing pancreatic acinar features in the absence of a pancreatic primary"],"prefix":"10.1111","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9822-7112","authenticated-orcid":false,"given":"Osman","family":"Yilmaz","sequence":"first","affiliation":[{"name":"Department of Pathology Beth Israel Deaconess Medical Center  Boston Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1799-1632","authenticated-orcid":false,"given":"Berk Kaan","family":"Akta\u015f","sequence":"additional","affiliation":[{"name":"Department of Pathology Beth Israel Deaconess Medical Center  Boston Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6129-1254","authenticated-orcid":false,"given":"Nuray","family":"Tezcan","sequence":"additional","affiliation":[{"name":"Department of Pathology Ko\u00e7 University  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4230-9308","authenticated-orcid":false,"given":"Vikram","family":"Deshpande","sequence":"additional","affiliation":[{"name":"Department of Pathology Beth Israel Deaconess Medical Center  Boston Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1308-3701","authenticated-orcid":false,"given":"Volkan","family":"Adsay","sequence":"additional","affiliation":[{"name":"Department of Pathology Ko\u00e7 University  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7020-9948","authenticated-orcid":false,"given":"Monika","family":"Vyas","sequence":"additional","affiliation":[{"name":"Department of Pathology Beth Israel Deaconess Medical Center  Boston Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyad176"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2008.10.006"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2011.127"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.5858\/1999-123-0707-CIJPH"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/hupa.2002.126345"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2019-0472-RA"},{"key":"e_1_2_9_8_1","first-page":"685","article-title":"Pancreatic acinar cell carcinoma. An analysis of cell lineage markers, p53 expression, and Ki\u2010ras mutation","volume":"143","author":"Hoorens A","year":"1993","journal-title":"Am. J. Pathol."},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181f133e9"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13000-023-01324-w"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-007-2070-8"},{"key":"e_1_2_9_12_1","first-page":"20","article-title":"Acinar cell carcinoma presenting as a duodenal mass: review of the literature and a case report","volume":"165","author":"Hamidian Jahromi A","year":"2013","journal-title":"J. La. State Med. 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