{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T20:14:01Z","timestamp":1783455241714,"version":"3.55.0"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T00:00:00Z","timestamp":1774656000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T00:00:00Z","timestamp":1774656000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004099","name":"Ligue Contre le Cancer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004099","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008979","name":"Soci\u00e9t\u00e9 Fran\u00e7aise d\u2019Endocrinologie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008979","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To validate whether the 2022 WHO classification improves the prediction of radioactive iodine refractory (RAIR) disease in advanced\u2010stage thyroid carcinomas and to identify associated histological predictive factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>\n                      A prospective cohort of 253 patients with pT3, pT4, or M1 thyroid carcinomas (TNM 2010), who underwent surgery between 2009 and 2018 and received at least one radioactive iodine dose, was analysed. Histological slides were reviewed using the 2022 WHO criteria, and clinical data were collected. Cox survival analyses and ROC curve evaluations were performed to identify factors associated with RAIR progression and assess the predictive performance of the new classification. Reclassification identified 28 low\u2010risk neoplasms, all with favourable outcomes. Among the remaining 225 malignant cases, 155 were well\u2010differentiated carcinomas (including 146 papillary carcinomas, 56 of which were aggressive subtypes) and 70 were high\u2010grade carcinomas (39 high\u2010grade differentiated and 31 poorly differentiated carcinomas). Forty patients (17.7%) developed RAIR disease. The 2022 WHO classification showed superior predictive performance compared with the 2004 WHO (AUC: 0.81 versus 0.60,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). Multivariate analysis identified tumour necrosis as independent predictive factor of RAIR disease, regardless of the mitotic index.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The 2022 WHO classification improves RAIR disease prediction, notably by recognizing high\u2010grade carcinomas as a distinct entity. High\u2010grade factors, especially tumour necrosis, which emerges as a key predictive factor, should be systematically reported in thyroid carcinoma pathology reports to enhance patient management and follow\u2010up.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/his.70148","type":"journal-article","created":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T07:35:42Z","timestamp":1774683342000},"page":"251-261","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Validating the 2022\n                    <scp>WHO<\/scp>\n                    classification in thyroid carcinomas: Prospective evidence for predicting iodine resistance"],"prefix":"10.1111","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-0070-2696","authenticated-orcid":false,"given":"Elise","family":"Andr\u00e9","sequence":"first","affiliation":[{"name":"Pathology Department Centre Hospitalier Lyon Sud, Hospices Civils de Lyon  Pierre B\u00e9nite France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8403-2148","authenticated-orcid":false,"given":"Laurine","family":"Mebarki","sequence":"additional","affiliation":[{"name":"F\u00e9d\u00e9ration d'Endocrinologie, Groupement Hospitalier Est, Hospices Civils de Lyon  Bron France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7248-7258","authenticated-orcid":false,"given":"Mirela","family":"Ilie","sequence":"additional","affiliation":[{"name":"Cancer Research Center of Lyon, INSERM1052 CNRS5286, Lyon 1 University  Villeurbanne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1955-2019","authenticated-orcid":false,"given":"Fabien","family":"Subtil","sequence":"additional","affiliation":[{"name":"Biostatistics Department Lyon 1 University, Hospices Civils de Lyon, CNRS, Laboratoire de Biom\u00e9trie et Biologie Evolutive IMR 5558  Villeurbanne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0251-4520","authenticated-orcid":false,"given":"Claire","family":"Bournaud","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetology CH de Roanne  Roanne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2515-7840","authenticated-orcid":false,"given":"Fran\u00e7oise","family":"Borson\u2010Chazot","sequence":"additional","affiliation":[{"name":"F\u00e9d\u00e9ration d'Endocrinologie, Groupement Hospitalier Est, Hospices Civils de Lyon  Bron France"},{"name":"Lyon 1 University  Villeurbanne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3927-2762","authenticated-orcid":false,"given":"Fran\u00e7oise","family":"Descotes","sequence":"additional","affiliation":[{"name":"Biochemistry and molecular biology department Centre Hospitalier Lyon Sud, Hospices Civils de Lyon  Pierre B\u00e9nite France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8703-737X","authenticated-orcid":false,"given":"Jean\u2010Christophe","family":"Lifante","sequence":"additional","affiliation":[{"name":"Lyon 1 University  Villeurbanne France"},{"name":"Endocrine Surgery Department Centre Hospitalier Lyon Sud, Hospices Civils de Lyon  Pierre B\u00e9nite France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mireille","family":"Bertholon\u2010Gr\u00e9goire","sequence":"additional","affiliation":[{"name":"Nuclear Medecine Department Groupement Hospitalier Est, Hospices Civils de Lyon  Bron France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5027-7660","authenticated-orcid":false,"given":"H\u00e9l\u00e8ne","family":"Lasolle","sequence":"additional","affiliation":[{"name":"F\u00e9d\u00e9ration d'Endocrinologie, Groupement Hospitalier Est, Hospices Civils de Lyon  Bron France"},{"name":"Lyon 1 University  Villeurbanne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6065-0756","authenticated-orcid":false,"given":"Myriam","family":"Decaussin\u2010Petrucci","sequence":"additional","affiliation":[{"name":"Pathology Department Centre Hospitalier Lyon Sud, Hospices Civils de Lyon  Pierre B\u00e9nite France"},{"name":"Lyon 1 University  Villeurbanne France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,28]]},"reference":[{"key":"e_1_2_12_2_1","unstructured":"Sant\u00e9 publique France.Estimations nationales de l'incidence et de la mortalit\u00e9 par cancer en France m\u00e9tropolitaine entre 1990 et 2018 \u2013 Volume 1: tumeurs solides.https:\/\/www.santepubliquefrance.fr\/maladies\u2010et\u2010traumatismes\/cancers\/cancer\u2010du\u2010sein\/documents\/rapport\u2010synthese\/estimations\u2010nationales\u2010de\u2010l\u2010incidence\u2010et\u2010de\u2010la\u2010mortalite\u2010par\u2010cancer\u2010en\u2010france\u2010metropolitaine\u2010entre\u20101990\u2010et\u20102018\u2010volume\u20101\u2010tumeurs\u2010solides\u2010etud."},{"key":"e_1_2_12_3_1","unstructured":"American Cancer Society.Thyroid cancer survival rates by type and stage.https:\/\/www.cancer.org\/cancer\/types\/thyroid\u2010cancer\/detection\u2010diagnosis\u2010staging\/survival\u2010rates.html."},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-2838"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12022-011-9176-5"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21739"},{"key":"e_1_2_12_7_1","volume-title":"Endocrine and neuroendocrine tumours. WHO Classification of Tumours series","author":"WHO Classification of Tumours Editorial Board","year":"2022"},{"key":"e_1_2_12_8_1","unstructured":"TUTHYREF.ENDOCAN TUTHYREF.https:\/\/www.tuthyref.com\/fr\/."},{"key":"e_1_2_12_9_1","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1016\/j.bulcan.2021.06.009","article-title":"G\u00e9notypage mol\u00e9culaire dans les cancers r\u00e9fractaires de la thyro\u00efde en 2021: quand, comment, et pourquoi? Un travail du r\u00e9seau TUTHYREF","volume":"108","author":"Fouchardi\u00e8re C","year":"2021","journal-title":"Bull. Cancer"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/cyt.12493"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2017.210"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.14550"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23515"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.549882"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.15157"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.12246"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2018.12.003"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1530\/ERC-16-0219"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina60050769"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2016.0386"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1530\/ERC-19-0048"}],"container-title":["Histopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/his.70148","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/his.70148","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/his.70148","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T19:23:46Z","timestamp":1783452226000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/his.70148"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,28]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1111\/his.70148"],"URL":"https:\/\/doi.org\/10.1111\/his.70148","archive":["Portico"],"relation":{},"ISSN":["0309-0167","1365-2559"],"issn-type":[{"value":"0309-0167","type":"print"},{"value":"1365-2559","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,28]]},"assertion":[{"value":"2025-10-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}