{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T08:55:41Z","timestamp":1791363341327,"version":"4.3.1"},"reference-count":5,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2026,11]]},"abstract":"\n Background<\/jats:title>\n Gastric\u2010type adenocarcinoma in situ (gAIS) is a rare, HPV\u2010independent precursor of cervical adenocarcinoma with incompletely defined histogenesis.<\/jats:p>\n <\/jats:sec>\n \n Aims<\/jats:title>\n To report a case of gAIS and its association with pyloric\u2010type gastric metaplasia.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods<\/jats:title>\n A case of gAIS in a 70\u2010year\u2010old woman with atypical glandular cells (Pap test) and negative HPV molecular testing was evaluated histologically and immunohistochemically.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Conization revealed atypical glandular epithelium. The lesion was CK7\/CDX2 positive, with mutant\u2010type p53 expression, and negative for CK20, PAX8 and p16. Adjacent pyloric\u2010type gastric metaplasia was identified.<\/jats:p>\n <\/jats:sec>\n \n Discussion<\/jats:title>\n The association with pyloric\u2010type metaplasia supports a possible metaplastic origin and highlights diagnostic challenges in limited samples.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n This case supports a possible link between gAIS and pyloric\u2010type gastric metaplasia, underscoring the importance of accurate recognition in HPV\u2010independent cervical lesions.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/his.70150","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T09:49:18Z","timestamp":1775036958000},"page":"892-894","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Endocervical gastric\u2010type\n AIS<\/scp>\n : a rare histologic finding that further supports the hypothesis of a pyloric\u2010type metaplastic origin"],"prefix":"10.1111","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4188-4247","authenticated-orcid":false,"given":"Michele","family":"Paudice","sequence":"first","affiliation":[{"name":"Department of Integrated Diagnostic and Surgical Sciences (DISC) University of Genoa Genoa Italy"},{"name":"IRCCS Azienda Ospedaliera Metropolitana (AOM) Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4698-6659","authenticated-orcid":false,"given":"Veronica","family":"Parrella","sequence":"additional","affiliation":[{"name":"Pathology Unit ASL2 Liguria Savona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9060-3854","authenticated-orcid":false,"given":"Giulia","family":"Scaglione","sequence":"additional","affiliation":[{"name":"Pathology Unit, Department of Woman and Child's Health and Public Health Sciences Fondazione Policlinico Universitario Agostino Gemelli IRCCS Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,1]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000855"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAP.0000000000000216"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.13993"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/cimb47090679"},{"key":"e_1_2_8_6_1","first-page":"153","article-title":"Evaluating HPV viral load and multiple infections for enhanced cervical cancer risk\u2010based assessment","volume":"15","author":"Varesano S","year":"2025","journal-title":"Life (Basel)"}],"container-title":["Histopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/his.70150","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/his.70150","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/his.70150","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T08:46:26Z","timestamp":1791362786000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/his.70150"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,1]]},"references-count":5,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["10.1111\/his.70150"],"URL":"https:\/\/doi.org\/10.1111\/his.70150","archive":["Portico"],"relation":{},"ISSN":["0309-0167","1365-2559"],"issn-type":[{"value":"0309-0167","type":"print"},{"value":"1365-2559","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,1]]},"assertion":[{"value":"2026-02-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}