{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T14:39:18Z","timestamp":1786113558237,"version":"build-2736575974"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2026,9]]},"abstract":"\n Aims<\/jats:title>\n Despite their common bronchial\/bronchiolar origin, the relationship between glandular\/mixed papillomas (GPs\/MPs) and bronchiolar adenomas (BAs) remains uncertain; therefore, this study aimed to elucidate it.<\/jats:p>\n <\/jats:sec>\n \n Methods and results<\/jats:title>\n \n We performed a combined clinicopathological and next\u2010generation sequencing analysis of 6 GP\/MP and 14 BA cases. The cases were classified into three groups based on histopathological features: Group A (classic GP\/MP), Group B (transitional morphology) and Group C (glandular predominant BA, lacks papillary structure). Analysis revealed a morphological continuum from Group A to Group C, characterized by a gradual transition from endobronchiolar papillary growth to alveolar glandular structures and a shift in the lining epithelium from pseudostratified ciliated columnar to cuboidal\/flat. Clinically, compared with Group C, Group A showed a higher proportion of males and larger tumour size, while Group B exhibited intermediate features. Genetically, GP\/MP frequently harboured\n BRAF<\/jats:italic>\n (83.3%) and\n AKT1<\/jats:italic>\n (66.6%) mutations, whereas BAs displayed a more diverse profile, including\n BRAF<\/jats:italic>\n (28.5%),\n AKT1<\/jats:italic>\n (21.4%),\n EGFR<\/jats:italic>\n (28.5%) and\n KRAS<\/jats:italic>\n (14.2%) mutations.\n BRAF<\/jats:italic>\n and\n AKT1<\/jats:italic>\n mutations were predominantly found in Groups A and B, whereas\n EGFR<\/jats:italic>\n and\n KRAS<\/jats:italic>\n mutations were more common in Group C.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n GP\/MP and BA represent the same disease spectrum, showing a continuous histomorphological change along the proximal\u2010to\u2010distal bronchial tree.\n BRAF<\/jats:italic>\n and\n AKT1<\/jats:italic>\n mutations are more frequently observed in GP\/MP and proximal\u2010type BA with papillary architecture, whereas BA lacking papillary structures is mainly characterized by\n EGFR<\/jats:italic>\n or\n KRAS<\/jats:italic>\n mutations. However, the\n BRAF<\/jats:italic>\n mutation rate in BA varies across geographical regions and appears to be associated with factors such as smoking.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/his.70161","type":"journal-article","created":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T13:59:53Z","timestamp":1780495193000},"page":"467-478","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bronchiolar adenoma and glandular papilloma\/mixed squamous cell and glandular papilloma represent a continuous disease spectrum: revelations from combined histological and genetic analysis"],"prefix":"10.1111","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8941-4514","authenticated-orcid":false,"given":"Zhenghua","family":"Piao","sequence":"first","affiliation":[{"name":"Department of Pathology Ningbo Clinical Pathology Diagnosis Center Jiangbei 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2869-5602","authenticated-orcid":false,"given":"Hairen","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pathology Ningbo Clinical Pathology Diagnosis Center Jiangbei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2072-5466","authenticated-orcid":false,"given":"Jiayi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Molecular Pathology Ningbo Clinical Pathology Diagnosis Center Jiangbei China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,3]]},"reference":[{"key":"e_1_2_11_2_1","volume-title":"Thoracic Tumours","author":"WHO Classification of 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and molecular characteristics of bronchial adenoma: An analysis of 88 cases","volume":"54","author":"Xu QX","year":"2025","journal-title":"Zhonghua Bing Li Xue Za Zhi"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pathol.2020.11.012"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001657"},{"key":"e_1_2_11_18_1","first-page":"212","article-title":"Clinicopathological and genetic characteristics of bronchial sialadenoma papilliferum: Report of four cases","volume":"51","author":"Liang L","year":"2022","journal-title":"Zhonghua Bing Li Xue Za 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