{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T00:19:36Z","timestamp":1789172376262,"version":"build-2803163510"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T00:00:00Z","timestamp":1778025600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T00:00:00Z","timestamp":1778025600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT, South Korea","doi-asserted-by":"publisher","award":["NRF\u20102022R1F1A1074801&RS\u20102025\u201024533997"],"award-info":[{"award-number":["NRF\u20102022R1F1A1074801&RS\u20102025\u201024533997"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016275","name":"Seoul National University Bundang Hospital","doi-asserted-by":"publisher","award":["02\u20102016\u2010012"],"award-info":[{"award-number":["02\u20102016\u2010012"]}],"id":[{"id":"10.13039\/100016275","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"\n Aims<\/jats:title>\n \n Triple\u2010positive diffuse large B\u2010cell lymphoma (\n TP<\/jats:styled-content>\n \u2010\n DLBCL<\/jats:styled-content>\n ), co\u2010expressing\n CD10<\/jats:styled-content>\n ,\n BCL6<\/jats:styled-content>\n and\n MUM1<\/jats:styled-content>\n , represents a rare subset with potential associations with\n \n IRF4<\/jats:italic>\n <\/jats:styled-content>\n rearrangements. This study investigated the clinicopathological spectrum and frequency of\n \n IRF4<\/jats:italic>\n <\/jats:styled-content>\n rearrangements in\n TP<\/jats:styled-content>\n \u2010\n DLBCL<\/jats:styled-content>\n and characterised large B\u2010cell lymphoma with\n \n IRF4<\/jats:italic>\n <\/jats:styled-content>\n rearrangement (\n LBCL<\/jats:styled-content>\n \u2010\n \n IRF4<\/jats:italic>\n <\/jats:styled-content>\n \u2010R) in a Korean population.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and results<\/jats:title>\n \n We retrospectively analysed 977 DLBCL cases diagnosed between 2003 and 2022. TP\u2010DLBCL accounted for 4.9% (48\/977) of all cases. Among 40 eligible TP\u2010DLBCL cases, 17.5% (7\/40) harboured\n IRF4<\/jats:italic>\n rearrangements by fluorescence in situ hybridization. Including two double\u2010positive cases, nine LBCL\u2010\n IRF4<\/jats:italic>\n \u2010R cases were characterized. TP\u2010DLBCL showed a significant predilection for low\u2010stage disease (stage I\u2013II: 30\/40, 75.0%) compared to non\u2010TP\u2010DLBCL (67\/143, 46.9%;\n P<\/jats:italic>\n \u2009=\u20090.002). LBCL\u2010\n IRF4<\/jats:italic>\n \u2010R patients were significantly younger than TP\u2010DLBCL without IRF4 rearrangement (mean age 40.6 versus 59.8\u2009years,\n P<\/jats:italic>\n \u2009=\u20090.049) with distinct features including preferential involvement of lymph nodes, tonsils and spleen (6\/9, 66.7%), less frequent multiple extranodal involvement (\n P<\/jats:italic>\n \u2009=\u20090.041) and conglomerated mass presentation. Most LBCL\u2010\n IRF4<\/jats:italic>\n \u2010R cases achieved complete remission, though one adult case with\n MYD88<\/jats:italic>\n mutation showed aggressive behaviour. Genetic profiling revealed heterogeneous patterns with\n IRF4<\/jats:italic>\n mutations in all sequenced cases, and recurrent\n PIM1<\/jats:italic>\n ,\n HIST1H1E<\/jats:italic>\n and\n CARD11<\/jats:italic>\n mutations.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n LBCL\u2010\n IRF4<\/jats:italic>\n \u2010R represents a clinically and molecularly heterogeneous entity extending beyond paediatric populations and head\u2010and\u2010neck locations.\n IRF4<\/jats:italic>\n fluorescence in situ hybridization testing should be considered in TP\u2010DLBCL cases, particularly in younger patients with localized disease.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/his.70169","type":"journal-article","created":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T06:15:49Z","timestamp":1778134549000},"page":"323-337","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinicopathological spectrum of\n CD10<\/scp>\n ,\n BCL6<\/scp>\n ,\n MUM1<\/scp>\n triple\u2010positive diffuse large B\u2010cell lymphoma and large B\u2010cell lymphoma with\n IRF4<\/i>\n rearrangement"],"prefix":"10.1111","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-2604-5817","authenticated-orcid":false,"given":"Sei","family":"Na","sequence":"first","affiliation":[{"name":"Department of Pathology Seoul National University Bundang Hospital Seongnam Korea"},{"name":"Department of Pathology Seoul National University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8774-1204","authenticated-orcid":false,"given":"Ki Rim","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pathology Seoul National University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8466-9681","authenticated-orcid":false,"given":"Yoon Kyung","family":"Jeon","sequence":"additional","affiliation":[{"name":"Department of Pathology Seoul National University College of Medicine Seoul Korea"},{"name":"Department of Pathology Seoul National University Hospital Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1599-5172","authenticated-orcid":false,"given":"Hyungjin","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pathology Seoul National University Bundang Hospital Seongnam Korea"},{"name":"Department of Pathology Seoul National University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9402-6372","authenticated-orcid":false,"given":"Jeong\u2010Ok","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University Bundang Hospital Seongnam Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5835-7219","authenticated-orcid":false,"given":"Ji Yun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University Bundang Hospital Seongnam Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8529-0232","authenticated-orcid":false,"given":"Sang\u2010A","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University Bundang Hospital Seongnam Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2776-5954","authenticated-orcid":false,"given":"Hongseok","family":"Yun","sequence":"additional","affiliation":[{"name":"Department of Genomic Medicine Seoul National University Hospital Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2792-0419","authenticated-orcid":false,"given":"Jin Ho","family":"Paik","sequence":"additional","affiliation":[{"name":"Department of Pathology Seoul National University Bundang Hospital Seongnam Korea"},{"name":"Department of Pathology Seoul National University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2015.94"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-05-1545"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2021006034"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2012.01113.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10238-022-00968-0"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-41954-8"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2012.076851"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-022-01620-2"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-01-643569"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022015851"},{"key":"e_1_2_10_12_1","volume-title":"Large B\u2010cell lymphoma with IRF4 rearrangement in: WHO classification of Tumours editorial board. Haematolymphoid tumours [internet; beta version ahead of print]","author":"Oschlies I","year":"2022"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-01-330795"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.5828"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/pin.13067"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2022.10.011"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.14885"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-023-03516-7"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.41.0985"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2020.03.015"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06045-0"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/database\/baz146"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019002699"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0000000000000355"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2007.03.017"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-023-03590-x"},{"key":"e_1_2_10_27_1","article-title":"Case series: Large B\u2010cell lymphoma with IRF4 rearrangement involving the lung and tonsil in two different patients","volume":"17","author":"Abdulrahim A","year":"2025","journal-title":"Cureus"}],"container-title":["Histopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/his.70169","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/his.70169","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/his.70169","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T19:24:07Z","timestamp":1783452247000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/his.70169"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,6]]},"references-count":26,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1111\/his.70169"],"URL":"https:\/\/doi.org\/10.1111\/his.70169","archive":["Portico"],"relation":{},"ISSN":["0309-0167","1365-2559"],"issn-type":[{"value":"0309-0167","type":"print"},{"value":"1365-2559","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,6]]},"assertion":[{"value":"2025-11-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}