{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T08:00:50Z","timestamp":1788681650435,"version":"build-2803163510"},"reference-count":46,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:00:00Z","timestamp":1780358400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:00:00Z","timestamp":1780358400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"abstract":"<jats:p>\n                    Traditional serrated adenoma (TSA) is the least common of the currently recognized serrated colorectal polyps and, thus, elucidating its pathogenesis, spectrum of morphological features and biological risk has been challenging. Most TSAs harbour either\n                    <jats:italic>KRAS<\/jats:italic>\n                    or\n                    <jats:italic>BRAF<\/jats:italic>\n                    mutations and may progress to adenocarcinoma\n                    <jats:italic>via<\/jats:italic>\n                    distinct carcinogenic pathways. TSAs with\n                    <jats:italic>KRAS<\/jats:italic>\n                    mutation are more commonly located in the distal colorectum, whereas\n                    <jats:italic>BRAF<\/jats:italic>\n                    \u2010mutant TSAs typically arise proximal to the transverse colon, may be associated with a background sessile serrated lesion and represent putative precursors of biologically aggressive\n                    <jats:italic>BRAF<\/jats:italic>\n                    \u2010mutant, mismatch repair\u2010proficient colorectal carcinomas. This review summarizes the evolution of the concept of TSA as a distinct pathological entity and its relationship to other neoplasms within the serrated neoplastic pathway. The molecular and histopathological characteristics of TSAs are outlined, with particular emphasis on the classification of lesions with mixed morphology, including those associated with non\u2010dysplastic serrated components and those showing progression to severe dysplasia, with the hope of improving their recognition. Although further studies are required to validate the proposed terminology, consistent classification of these lesions is essential to improve recognition and to advance understanding of this uncommon pathway to colorectal carcinoma.\n                  <\/jats:p>","DOI":"10.1111\/his.70194","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T08:15:12Z","timestamp":1780388112000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Traditional serrated adenoma of the colorectum: Evolving concepts in histological classification and terminology"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7671-2651","authenticated-orcid":false,"given":"Christophe","family":"Rosty","sequence":"first","affiliation":[{"name":"Envoi Specialist Pathologists  Kelvin Grove Queensland Australia"},{"name":"Faculty of Medicine University of Queensland  Brisbane Australia"},{"name":"Colorectal Oncogenomic Group, Department of Clinical Pathology The University of Melbourne  Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8424-1765","authenticated-orcid":false,"given":"Maurice B.","family":"Loughrey","sequence":"additional","affiliation":[{"name":"Centre for Public Health Queen's University of Belfast  Belfast UK"},{"name":"Department of Cellular Pathology Belfast Health and Social Care Trust  Belfast UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3148-9243","authenticated-orcid":false,"given":"Taiki","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology National Cancer Center Hospital  Tokyo Japan"},{"name":"Department of Pathology, School of Medicine Keio University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9200-4118","authenticated-orcid":false,"given":"Markus","family":"M\u00e4kinen","sequence":"additional","affiliation":[{"name":"Translational Medicine Research Unit, Medical Research Center Oulu Oulu University Hospital, and University of Oulu  Oulu Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2692-221X","authenticated-orcid":false,"given":"Rish K.","family":"Pai","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Mount Sinai Hospital  Toronto Ontario Canada"},{"name":"Department of Laboratory Medicine and Pathobiology University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0884-8981","authenticated-orcid":false,"given":"Shigeki","family":"Sekine","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medicine Keio University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6068-4617","authenticated-orcid":false,"given":"Rhonda K.","family":"Yantiss","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of Miami Miller School of Medicine  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0435-7521","authenticated-orcid":false,"given":"Iris D.","family":"Nagtegaal","sequence":"additional","affiliation":[{"name":"Department of Pathology, Radboud Institute for Molecular Life Sciences Radboud University Medical Center  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,2]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1038\/s41379-019-0280-2","article-title":"An update on the morphology and molecular pathology of serrated colorectal polyps and associated carcinomas","volume":"32","author":"Pai RK","year":"2019","journal-title":"Mod. 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