{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T09:10:48Z","timestamp":1788858648693,"version":"build-2803163510"},"reference-count":43,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Testicular sex cord\u2010stromal tumours (TSCSTs) are rare neoplasms that arise from (or show differentiation to) elements derived from the sex cords or intertubular stroma. The current classification (World Health Organization, 2022) is based almost entirely on morphology, with many tumour types such as granulosa cell tumours being defined based on their resemblance to ovarian counterparts. Recent studies have uncovered new clinicopathological, molecular and biological nuances within this group of tumours, underscoring differences with ovarian homologues.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Considering the new data, a group of genitourinary pathology experts (Testicular Sex Cord\u2010Stromal Tumour [TESST] group) has proposed a revised \u2018TESST classification\u2019 that incorporates the best available evidence. This classification is structured and hierarchical, composed of the following tiers: (1) group, (2) category, (3) entity and (4) histological pattern. \u2018Group\u2019 refers to the histological compartment a specific tumour belongs to (sex cords, stroma or both), whereas \u2018category\u2019 is defined by the phenotype of the tumour, taking non\u2010neoplastic elements of the ovary and testis as a reference. The third tier, \u2018entity\u2019, refers to neoplasms with shared clinicopathological and\/or molecular features that justify classifying them as distinct types. Lastly, \u2018histological patterns\u2019 are recurrent morphological variations within entities that are not linked to distinct clinicopathological or molecular features.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We propose a classification that will provide a framework to improve current clinical management and guide future research in the field.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/his.70207","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T06:50:53Z","timestamp":1783579853000},"page":"638-649","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A novel classification of testicular sex cord\u2010stromal tumours from the Testicular Sex Cord\u2010Stromal Tumour (\n                    <scp>TESST<\/scp>\n                    ) group: a collaboration of the Genitourinary Pathology Society (\n                    <scp>GUPS<\/scp>\n                    ) and the International Society of Urological Pathology\u00a0(\n                    <scp>ISUP<\/scp>\n                    )"],"prefix":"10.1111","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8817-6331","authenticated-orcid":false,"given":"Andres M.","family":"Acosta","sequence":"first","affiliation":[{"name":"Department of Pathology Indiana University  Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Bremmer","sequence":"additional","affiliation":[{"name":"Institute of Pathology University Medical Center G\u00f6ttingen  G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C.","family":"Cheville","sequence":"additional","affiliation":[{"name":"Department of Pathology Mayo Clinic  Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1914-0743","authenticated-orcid":false,"given":"Maurizio","family":"Colecchia","sequence":"additional","affiliation":[{"name":"Department of Pathology Universita Vita Salute San Raffaele  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Comperat","sequence":"additional","affiliation":[{"name":"Department of Pathology Medical University Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristine","family":"Cornejo","sequence":"additional","affiliation":[{"name":"Department of Pathology Indiana University  Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilek E.","family":"Baydar","sequence":"additional","affiliation":[{"name":"Department of Pathology Koc University School of Medicine  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony J.","family":"Gill","sequence":"additional","affiliation":[{"name":"Department of Pathology, Sydney Medical School University of Sydney  Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"del Pilar Gonzalez\u2010Peramato","sequence":"additional","affiliation":[{"name":"Department of Pathology University Hospital La Paz, Universidad Aut\u00f3noma de Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5163-6955","authenticated-orcid":false,"given":"Sounak","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Pathology Mayo Clinic  Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle S.","family":"Hirsch","sequence":"additional","affiliation":[{"name":"Department of Pathology MassGeneralBrigham\/Harvard Medical School  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad T.","family":"Idrees","sequence":"additional","affiliation":[{"name":"Department of Pathology Indiana University  Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia\u2010Sui","family":"Kao","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Diagnostics Institute Cleveland Clinic  Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona","family":"MacLean","sequence":"additional","affiliation":[{"name":"Department of Pathology, Douglass Hanly Moir Pathology Sonic Healthcare  Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0990-1115","authenticated-orcid":false,"given":"Andres","family":"Matoso","sequence":"additional","affiliation":[{"name":"Department of Pathology Johns Hopkins University  Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohit","family":"Mehra","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Michigan  Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4140-0671","authenticated-orcid":false,"given":"Santosh","family":"Menon","sequence":"additional","affiliation":[{"name":"Department of Pathology Tata Memorial Centre  Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3231-6870","authenticated-orcid":false,"given":"Kvetoslava","family":"Michalova","sequence":"additional","affiliation":[{"name":"Department of Pathology Charles University, Faculty of Medicine in Plzen, Biopticka Laborator, Ltd  Plzen Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sambit K.","family":"Mohanty","sequence":"additional","affiliation":[{"name":"Department of Pathology CORE Diagnostics  Gurgaon Haryana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5698-3702","authenticated-orcid":false,"given":"Miguel","family":"Reyes\u2010Mugica","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Miami Miller School of Medicine  Miami FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6630-4881","authenticated-orcid":false,"given":"Maria Rosaria","family":"Raspollini","sequence":"additional","affiliation":[{"name":"Histopathology and Molecular Diagnostics University Hospital Careggi and University of Florence  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7233-2361","authenticated-orcid":false,"given":"Ankur R.","family":"Sangoi","sequence":"additional","affiliation":[{"name":"Department of Pathology Stanford University  Stanford CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynette M.","family":"Sholl","sequence":"additional","affiliation":[{"name":"Department of Pathology MassGeneralBrigham\/Harvard Medical School  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Siegmund","sequence":"additional","affiliation":[{"name":"Department of Pathology MassGeneralBrigham\/Harvard Medical School  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satish K.","family":"Tickoo","sequence":"additional","affiliation":[{"name":"Department of Pathology Memorial Sloan\u2010Kettering Cancer Center  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4855-4366","authenticated-orcid":false,"given":"Toyonori","family":"Tsuzuki","sequence":"additional","affiliation":[{"name":"Department of Surgical Pathology Aichi Medical University  Nagakute Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas M.","family":"Ulbright","sequence":"additional","affiliation":[{"name":"Department of Pathology Indiana University  Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean R.","family":"Williamson","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Diagnostics Institute Cleveland Clinic  Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asli","family":"Yilmaz","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Molecular Pathology Alberta Precision Labs and University of Calgary  Calgary AB Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5474-8696","authenticated-orcid":false,"given":"Daniel M.","family":"Berney","sequence":"additional","affiliation":[{"name":"Centre of Cancer Biomarkers and Biotherapeutics, Barts Cancer Institute, Charterhouse Square Queen Mary University of London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,8]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.14675"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.15482"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.modpat.2025.100804"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/003655999750015998"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000132"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199109000-00002"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13000-023-01351-7"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.modpat.2023.100152"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2018.04.003"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.14599"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3180309e33"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.15513"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.modpat.2025.100891"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-020-03326-3"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000450"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddv373"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-2710"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-21-3394"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.modpat.2023.100142"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200205000-00001"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000002022"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/10668969231195043"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12672-025-03704-8"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-0183"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-021-00845-3"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.14859"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2012.08.057"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199703000-00005"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e318286c129"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2011.04.017"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.1177\/10668969231160256"},{"key":"e_1_2_14_33_1","doi-asserted-by":"publisher","DOI":"10.21037\/tau-22-179"},{"key":"e_1_2_14_34_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPGSCD1DGNZ0QO"},{"key":"e_1_2_14_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1996.tb01400.x"},{"key":"e_1_2_14_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-020-02957-8"},{"key":"e_1_2_14_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.14825"},{"key":"e_1_2_14_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2024.105652"},{"key":"e_1_2_14_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-022-01155-y"},{"key":"e_1_2_14_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.modpat.2023.100368"},{"key":"e_1_2_14_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.modpat.2024.100587"},{"key":"e_1_2_14_42_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200004000-00007"},{"key":"e_1_2_14_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-020-02843-3"},{"key":"e_1_2_14_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.15360"}],"container-title":["Histopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/his.70207","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/his.70207","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/his.70207","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T08:43:24Z","timestamp":1788857004000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/his.70207"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,8]]},"references-count":43,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1111\/his.70207"],"URL":"https:\/\/doi.org\/10.1111\/his.70207","archive":["Portico"],"relation":{},"ISSN":["0309-0167","1365-2559"],"issn-type":[{"value":"0309-0167","type":"print"},{"value":"1365-2559","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,8]]},"assertion":[{"value":"2026-03-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}