{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T08:55:43Z","timestamp":1791363343027,"version":"4.3.1"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T00:00:00Z","timestamp":1782432000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T00:00:00Z","timestamp":1782432000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Low\u2010grade spindle cell lesions of the breast (LGSCL\u2010B) are uncommon, with malignant counterparts being particularly rare. Management recommendations for desmoid\u2010type fibromatosis (DF), in particular, have evolved.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p>\n                      A retrospective review of cases from 2000 to 2024 was conducted using LGSCL\u2010B\u2010related keyword searches. Clinical features were assessed, and when available, core needle biopsy (CNB) findings were correlated with excision specimens and imaging. Of 68 LGSCL\u2010B samples, DF was the most frequent subtype (28 cases, 41%). A total of six resections were negative for \u03b2\u2010catenin expression, including three resections from cases diagnosed as DF and three resections from cases categorized as undetermined on CNB and subsequently finalized as DF on resection. Myofibroblastoma occurred in 12 patients, more often in men (58%), with lipid\u2010rich (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20093) and myxoid (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20092) variants. One lesion initially diagnosed as a solitary fibrous tumour was reclassified as a palisaded myofibroblastoma. Malignancy was identified in two biopsies: a spindle cell sarcoma and a fibromatosis\u2010like metaplastic carcinoma; the latter was reclassified at resection as a malignant phyllodes tumour with heterologous bone formation. Thirteen CNB (19%) were indeterminate, including one described with ambiguous wording, a spindle cell sarcoma with a differential encompassing both benign and malignant entities.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Most LGSCL\u2010B can be classified on CNB, but approximately one\u2010fifth yield indeterminate results. Diagnostic challenges include overlapping morphological features, immunohistochemical profiles and potential reclassification at resection. Awareness of these pitfalls, along with selective use of adjunct molecular testing, may enhance diagnostic accuracy and reduce overtreatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/his.70228","type":"journal-article","created":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T06:42:08Z","timestamp":1782542528000},"page":"786-795","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Navigating diagnostic challenges in low\u2010grade spindle cell lesions of the breast: a retrospective review"],"prefix":"10.1111","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-3171-4553","authenticated-orcid":false,"given":"Graham","family":"Stoddard","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Oregon Health &amp; Science University  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7519-6296","authenticated-orcid":false,"given":"Rabeka","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Oregon Health &amp; Science University  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4424-7715","authenticated-orcid":false,"given":"Ozlen","family":"Saglam","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Oregon Health &amp; Science University  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,26]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001517"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdx323"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12082135"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2018.09.018"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2007.02893.x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semdp.2017.05.010"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2020.10.035"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/02656736.2011.597047"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14205045"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2024.1805"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semdp.2017.05.006"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/S0046-8177(03)00414-3"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000301"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-021-03162-x"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.path.2021.11.005"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13058-016-0692-6"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcu.22818"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/tbj.12835"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000299"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/106689690000800204"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2011.118"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/tbj.13956"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.5114\/pjp.2024.143232"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13000-016-0480-8"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200102000-00010"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2007.02794.x"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.path.2017.09.005"},{"key":"e_1_2_10_29_1","article-title":"Locally advanced inflammatory Myofibroblastic tumor treated with targeted therapy: A case report and literature review","volume":"14","author":"Durham C","year":"2022","journal-title":"Cureus."},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/tbj.12612"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4741.2006.00370.x"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-0753-4943"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2023.06.012"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3180321959"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.13423"},{"key":"e_1_2_10_36_1","first-page":"369","article-title":"Giant nodular pseudoangiomatous stromal hyperplasia (PASH) of the breast presenting as a rapidly growing tumour","volume":"61","author":"Mezzabotta M","year":"2009","journal-title":"Chir. 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