{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T08:55:42Z","timestamp":1791363342072,"version":"4.3.1"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T00:00:00Z","timestamp":1783209600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T00:00:00Z","timestamp":1783209600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>\n                      Myxomas are benign soft tissue neoplasms typically driven by activating\n                      <jats:italic>GNAS<\/jats:italic>\n                      mutations. However, a subset lacks this alteration and remains molecularly undefined. Recent reports have implicated\n                      <jats:italic>MAP3K<\/jats:italic>\n                      family gene fusions in rare myxoid neoplasms sharing features with myxoma.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>\n                      In this study, we characterise 39\n                      <jats:italic>MAP3K<\/jats:italic>\n                      \u2010rearranged myxoid tumours by integrating clinical, histopathological, immunohistochemical and molecular data. The cohort comprised predominantly middle\u2010aged adults, with tumours distributed across a wide anatomic range (limbs, trunk, face), often in superficial locations. Histologically, the tumours were composed of bland spindle or histiocytoid cells embedded in an abundant myxoid stroma with features mimicking cellular myxoma, such as intermediate\u2010to\u2010high cellularity and broad fibrous septa. High\u2010grade pleomorphism and necrosis were consistently absent. Immunohistochemistry revealed frequent CD34 and HMGA2 positivity, a low Ki\u201067 proliferation index, and preserved PRKAR1A expression. RNA sequencing identified diverse\n                      <jats:italic>MAP3K<\/jats:italic>\n                      gene fusions, most notably\n                      <jats:italic>MSI2<\/jats:italic>\n                      ::\n                      <jats:italic>MAP3K3<\/jats:italic>\n                      and\n                      <jats:italic>MAP3K8<\/jats:italic>\n                      ::\n                      <jats:italic>MAP3K3<\/jats:italic>\n                      , alongside several unique fusion partners. Transcriptomic clustering demonstrated a relationship between\n                      <jats:italic>MAP3K<\/jats:italic>\n                      \u2010rearranged tumours,\n                      <jats:italic>GNAS<\/jats:italic>\n                      \u2010mutant myxomas and a proximity with myxofibrosarcomas, while clearly distinguishing them from other myxoid sarcomas. Clinical follow\u2010up indicated an indolent course with no evidence of metastasis and rare local recurrences; notably, one patient with positive surgical margins remained disease\u2010free several years postoperatively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      <jats:italic>MAP3K<\/jats:italic>\n                      \u2010rearranged myxoid tumours represent a molecularly distinct subset of benign neoplasms that overlap histologically with cellular myxoma and must be distinguished from low\u2010grade myxofibrosarcoma.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/his.70230","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T06:23:20Z","timestamp":1783319000000},"page":"796-806","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Myxoid neoplasms with\n                    <scp>MAP3K<\/scp>\n                    kinase fusion: a study of 39 cases"],"prefix":"10.1111","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9882-2162","authenticated-orcid":false,"given":"Nicolas","family":"Macagno","sequence":"first","affiliation":[{"name":"Department of Pathology APHM, Timone  Marseille France"},{"name":"Aix Marseille Univ, INSERM, MMG, UMR1251, Marmara Institute  Marseille France"},{"name":"NETSARC, French Sarcoma Network  Lyon France"},{"name":"Department of Biopathology Centre L\u00e9on B\u00e9rard  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3321-6951","authenticated-orcid":false,"given":"Diane","family":"Frankel","sequence":"additional","affiliation":[{"name":"Cellular Biology Department Aix Marseille Univ, APHM, INSERM, MMG, Timone  Marseille France"},{"name":"Centre L\u00e9on B\u00e9rard, Cancer Research Center of Lyon Universit\u00e9 de Lyon, Universit\u00e9 Claude Bernard Lyon 1, INSERM 1052, CNRS 5286  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8568-8640","authenticated-orcid":false,"given":"Alexandra","family":"Meurgey","sequence":"additional","affiliation":[{"name":"NETSARC, French Sarcoma Network  Lyon France"},{"name":"Department of Biopathology Centre L\u00e9on B\u00e9rard  Lyon 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Biopathology Centre L\u00e9on B\u00e9rard  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Gouin","sequence":"additional","affiliation":[{"name":"NETSARC, French Sarcoma Network  Lyon France"},{"name":"Department of Surgery Centre L\u00e9on B\u00e9rard  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7383-0246","authenticated-orcid":false,"given":"Gualter","family":"Vaz","sequence":"additional","affiliation":[{"name":"NETSARC, French Sarcoma Network  Lyon France"},{"name":"Department of Surgery Centre L\u00e9on B\u00e9rard  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9904-166X","authenticated-orcid":false,"given":"Mehdi","family":"Brahmi","sequence":"additional","affiliation":[{"name":"NETSARC, French Sarcoma Network  Lyon France"},{"name":"Centre L\u00e9on B\u00e9rard, Cancer Research Center of Lyon Universit\u00e9 de Lyon, Universit\u00e9 Claude Bernard Lyon 1, INSERM 1052, CNRS 5286  Lyon France"},{"name":"Department of Oncology Centre L\u00e9on B\u00e9rard  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6637-3526","authenticated-orcid":false,"given":"Armelle","family":"Dufresne","sequence":"additional","affiliation":[{"name":"NETSARC, French Sarcoma Network  Lyon France"},{"name":"Centre L\u00e9on B\u00e9rard, Cancer Research Center of Lyon Universit\u00e9 de Lyon, Universit\u00e9 Claude Bernard Lyon 1, INSERM 1052, CNRS 5286  Lyon France"},{"name":"Department of Oncology Centre L\u00e9on B\u00e9rard  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6839-7102","authenticated-orcid":false,"given":"Anne\u2010Val\u00e9rie","family":"Decouvelaere","sequence":"additional","affiliation":[{"name":"CYPATH  Lyon 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