{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T08:55:45Z","timestamp":1791363345903,"version":"4.3.1"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T00:00:00Z","timestamp":1782604800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T00:00:00Z","timestamp":1782604800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Malignant adenomyoepithelioma (M\u2010AME) is an extremely rare and morphologically diverse breast tumour, posing significant diagnostic and management challenges. We present seven cases of M\u2010AME with different histological compositions to contribute additional data to the existing literature. Through these cases, we review and discuss potential pitfalls and classification challenges in diagnosing M\u2010AME.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>We performed a retrospective clinicopathological review of seven cases of M\u2010AME from women aged 45\u201374\u2009years (median 53\u2009years). Each case exhibited distinct architectural patterns and compositions of classic and malignant components: (1) Adenomyoepithelioma (AME) with metaplastic spindle and squamous cell carcinoma; (2) Invasive AME with an aberrant immunohistochemical profile; (3) Invasive AME with an adenomyoepithelial adenosis pattern; (4) Metaplastic spindle cell carcinoma arising from AME with suspicion of M\u2010AME in situ; (5) Atypical AME with late lung metastasis harbouring HRAS p.G13R and in\u2010frame PIK3R1 deletion; (6) and (7) M\u2010AME in situ.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>M\u2010AME encompasses heterogeneous patterns that overlap with the infiltrative\u2010like pattern of classic AME (adenomyoepithelial adenosis form of tubular AME) and metaplastic breast carcinoma. Recognition of the underlying AME architecture, coupled with immunohistochemical and molecular correlation, supports pragmatic classification into in situ or invasive M\u2010AME or conventional breast carcinoma arising in the context of AME. Together with clinical, radiological, and molecular correlations, this approach can help guide appropriate management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/his.70233","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:27Z","timestamp":1782691227000},"page":"807-823","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Malignant adenomyoepithelioma of the breast: seven cases illustrating morphological diversity and diagnostic challenges"],"prefix":"10.1111","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1799-0720","authenticated-orcid":false,"given":"Sompon","family":"Apornvirat","sequence":"first","affiliation":[{"name":"Chulabhorn International College of Medicine Thammasat University  Pathum Thani Thailand"},{"name":"Department of Pathology and Laboratory Medicine KK Women's and Children's Hospital  Singapore 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Duke\u2010NUS Breast Centre  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ga Sze","family":"Hong","sequence":"additional","affiliation":[{"name":"GS Hong Surgical Care Pte Ltd, Mount Elizabeth Medical Centre  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgette","family":"Chan","sequence":"additional","affiliation":[{"name":"Dr Georgette Chan Breast Clinic, Mount Elizabeth Medical Centre  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Ang","sequence":"additional","affiliation":[{"name":"OncoCare Cancer Centre, Mount Elizabeth Novena Specialist Centre  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Cheng","sequence":"additional","affiliation":[{"name":"Division of Breast Surgery, Department of Surgery Changi General Hospital  Singapore Singapore"},{"name":"SingHealth Duke\u2010NUS Breast Centre  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tse Hui","family":"Lim","sequence":"additional","affiliation":[{"name":"Division of Pathology, Department of Haematology Singapore General Hospital  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7648-8896","authenticated-orcid":false,"given":"Stephen B.","family":"Fox","sequence":"additional","affiliation":[{"name":"Department of Pathology, Peter MacCallum Cancer Centre and Collaborative Centre for Cancer Genomic Medicine University of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5009-5525","authenticated-orcid":false,"given":"Emad","family":"Rakha","sequence":"additional","affiliation":[{"name":"Academic Unit for Translational Medical Sciences, School of Medicine University of Nottingham  Nottingham UK"},{"name":"Department of Pathology Hamad 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