{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T12:29:25Z","timestamp":1793795365433,"version":"4.6.1"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004622","name":"KWF Kankerbestrijding","doi-asserted-by":"publisher","award":["project number 12950"],"award-info":[{"award-number":["project number 12950"]}],"id":[{"id":"10.13039\/501100004622","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2026,12]]},"abstract":"<jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>\n                      Germline\n                      <jats:italic>BRCA1\/2<\/jats:italic>\n                      pathogenic variant carriers are at increased risk for high\u2010grade serous carcinoma (HGSC) and are therefore advised to have a risk\u2010reducing salpingo\u2010oophorectomy (RRSO) around the age of 40. A risk of 0.9% to develop peritoneal HGSC (pHGSC) remains, which increases up to 27.5% when serous tubal intraepithelial carcinoma (STIC) is detected at RRSO. The relationship between the detection of STIC and the occurrence of pHGSC is still poorly understood. Here, we investigated the role of tissue sampling by examining deeper sections of the tubal tissue of RRSO specimens.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Four groups of patients were included: (1) STIC without pHGSC (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20095); (2) STIC with pHGSC (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20094); (3) no STIC and no pHGSC (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20095); and (4) no STIC and pHGSC (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20095). Follow\u2010up time was 10\u2009years or until the development of pHGSC. Deeper sections were cut at 150\u2009\u03bcm intervals. A deep learning model was used to support STIC detection.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A focus of isolated STIC or HGSC was found in the deeper sections of all patients who developed pHGSC, while these patients did not have STIC or HGSC at the initial diagnosis. No patients with STIC and pHGSC showed HGSC in the deeper sections. We observed that five STICs presented as serous tubal intraepithelial lesions (STILs) in adjacent slides based on low Ki\u201067 expression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings underscore the hypothesis that pHGSC originates in the fallopian tube and confirm that invasiveness is not necessary for disease progression of STIC towards pHGSC. Furthermore, deeper sections might be of additional value when STIL is diagnosed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/his.70249","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T08:38:55Z","timestamp":1786523935000},"page":"964-974","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Additional sectioning and\n                    <scp>AI<\/scp>\n                    \u2010assisted diagnosis reveal underdiagnosis of serous (pre)malignancies in fallopian tube specimen from\n                    <i>BRCA<\/i>\n                    1\/2 carriers"],"prefix":"10.1111","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-8427-1410","authenticated-orcid":false,"given":"Anouk B","family":"Bouwmeester","sequence":"first","affiliation":[{"name":"Department of Pathology Radboudumc  Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8916-1568","authenticated-orcid":false,"given":"Tamar A","family":"Gootzen","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics Radboudumc  Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1676-8455","authenticated-orcid":false,"given":"Marielle","family":"Nobbenhuis","sequence":"additional","affiliation":[{"name":"Department of Gynecological Oncology The Royal Marsden NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2591-6982","authenticated-orcid":false,"given":"Vilius","family":"Rudaitis","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Clinic of Obstetrics and Gynecology Vilnius University  Vilnius Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8157-592X","authenticated-orcid":false,"given":"Caroline B","family":"van den Berg","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics ErasmusMC  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8899-7412","authenticated-orcid":false,"given":"Heleen J","family":"van Beekhuizen","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics ErasmusMC  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2830-8336","authenticated-orcid":false,"given":"Luthy SM","family":"Alcal\u00e1","sequence":"additional","affiliation":[{"name":"Department of Pathology Amphia hospital  Breda the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0971-1859","authenticated-orcid":false,"given":"Dineke PM","family":"Smedts","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics Amphia hospital  Breda the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3919-3922","authenticated-orcid":false,"given":"Nicole CM","family":"Visser","sequence":"additional","affiliation":[{"name":"Department of Pathology PAMM  Eindhoven the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3586-6683","authenticated-orcid":false,"given":"Viola","family":"Verhoef","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics Maxima Medical Center  Veldhoven the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9499-5310","authenticated-orcid":false,"given":"Trudy GN","family":"Jonges","sequence":"additional","affiliation":[{"name":"Department of Pathology University Medical Center Utrecht  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1829-7773","authenticated-orcid":false,"given":"Ronald P","family":"Zweemer","sequence":"additional","affiliation":[{"name":"Department of Gynecological Oncology University Medical Center Utrecht  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0873-5362","authenticated-orcid":false,"given":"Alicia","family":"Leon\u2010Catillo","sequence":"additional","affiliation":[{"name":"Department of Pathology Antoni van Leeuwenhoek  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0635-2870","authenticated-orcid":false,"given":"Carlijn","family":"Lems","sequence":"additional","affiliation":[{"name":"Department of Pathology Radboudumc  Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5578-092X","authenticated-orcid":false,"given":"Joanne A","family":"de Hullu","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics Radboudumc  Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7982-0754","authenticated-orcid":false,"given":"Jeroen AWM","family":"van der Laak","sequence":"additional","affiliation":[{"name":"Department of Pathology Radboudumc  Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6097-1579","authenticated-orcid":false,"given":"Miranda P","family":"Steenbeek","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics Radboudumc  Nijmegen the Netherlands"},{"name":"Department of Gynecology and Obstetrics Catharina Hospital  Eindhoven the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1039-3488","authenticated-orcid":false,"given":"Michiel","family":"Simons","sequence":"additional","affiliation":[{"name":"Department of Pathology Radboudumc  Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,12]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21763"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(23)00335-2"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)00731-5"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21456"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jncics\/pkaa029"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.7112"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2022.09.035"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.21.02016"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2018.08.016"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.13248"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2021.10.072"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2024.05.010"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.3023"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181dcede7"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.17919"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.13845"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31822f58bc"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0b013e3181c713a8"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/2056-4538.70006"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2018.11.033"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2020.01.040"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13048-019-0525-1"},{"key":"e_1_2_12_24_1","first-page":"19","article-title":"Pathology databanking and biobanking in The Netherlands, a central role for PALGA, the nationwide histopathology and cytopathology data network and archive","volume":"29","author":"Casparie M","year":"2007","journal-title":"Cell. Oncol."},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44294-024-00016-0"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0b013e318264ae09"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-18-0009"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181bc6059"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0000000000000604"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.14902"},{"key":"e_1_2_12_31_1","volume-title":"Female genital tumours","author":"WHO Classification of Tumours Editorial Board","year":"2020"}],"container-title":["Histopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/his.70249","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/his.70249","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/his.70249","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T12:04:44Z","timestamp":1793793884000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/his.70249"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,12]]},"references-count":30,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["10.1111\/his.70249"],"URL":"https:\/\/doi.org\/10.1111\/his.70249","archive":["Portico"],"relation":{},"ISSN":["0309-0167","1365-2559"],"issn-type":[{"value":"0309-0167","type":"print"},{"value":"1365-2559","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,12]]},"assertion":[{"value":"2026-05-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}