{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T06:48:00Z","timestamp":1785826080677,"version":"3.56.0"},"reference-count":33,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To characterize the endoscopic features of periappendiceal lesions and histopathological features of appendiceal lesions in patients with conventional ulcerative colitis (UC), particularly in relation to disease duration, and compare these findings to those\u00a0observed in patients with primary sclerosing cholangitis\u2010associated UC (PSC\u2010UC) to clarify differences in appendiceal involvement and underlying pathophysiology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>This retrospective, two\u2010centre study included 158 UC patients and 7 PSC\u2010UC patients undergoing total colectomy involving the appendix between 2011 and 2025. Twenty\u2010five non\u2010UC patients served as controls. Pathologists blindly evaluated appendiceal sections for active inflammation, fibrous obliteration (FO) and crypt architectural distortion. Among patients with UC, 92% of the appendices exhibited active inflammation or FO, frequently accompanied by chronic architectural distortion and mucosal destruction, whereas no controls showed active inflammation.<\/jats:p>\n                    <jats:p>Appendiceal lesions in patients with UC demonstrated time\u2010dependent changes: active inflammation was predominant (64%) within 5\u2009years of disease onset, whereas complete FO was most frequent (75%) after 20\u2009years. In cases with preoperative periappendiceal red patch, histological continuity from distal FO to proximal active inflammation was confirmed within the same appendix. Conversely, despite extensive colonic inflammation, no PSC\u2010UC cases exhibited active appendiceal inflammation, and most appendices remained histologically intact.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Appendiceal lesions in patients with conventional UC show a time\u2010dependent transition from active inflammation to long\u2010term fibrous obliteration. These findings suggest that appendiceal inflammation may be more relevant in the early phase of disease, with possible implications for appendectomy\u2010based therapeutic strategies. The absence of appendiceal inflammation in patients with PSC\u2010UC further supports a pathophysiological difference from conventional UC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/his.70251","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T06:17:42Z","timestamp":1785824262000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Time\u2010dependent histopathological remodelling of the appendix in patients with ulcerative colitis"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5272-6458","authenticated-orcid":false,"given":"Kurara","family":"Yamamoto","sequence":"first","affiliation":[{"name":"Department of Human Pathology Graduate School of Institute of Science Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5232-3711","authenticated-orcid":false,"given":"Takanori","family":"Nishiguchi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Tokyo Yamate Medical Center  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6651-3543","authenticated-orcid":false,"given":"Keiko","family":"Abe","sequence":"additional","affiliation":[{"name":"Department of Pathology Tokyo Yamate Medical Center  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5606-4985","authenticated-orcid":false,"given":"Yoko","family":"Tateishi","sequence":"additional","affiliation":[{"name":"Department of Pathology Yokohama Municipal Citizens' Hospital  Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7965-7405","authenticated-orcid":false,"given":"Hiroyuki","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Pathology Yokohama Municipal Citizens' Hospital  Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4630-905X","authenticated-orcid":false,"given":"Makoto","family":"Makishima","sequence":"additional","affiliation":[{"name":"Division of Biochemistry, Department of Biomedical Sciences Nihon University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1836-1763","authenticated-orcid":false,"given":"Kenichi","family":"Ohashi","sequence":"additional","affiliation":[{"name":"Department of Human Pathology Graduate School of Institute of Science Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3883-4353","authenticated-orcid":false,"given":"Kouhei","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Human Pathology Graduate School of Institute of Science Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3750-1151","authenticated-orcid":false,"given":"Soh","family":"Okano","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Tokyo Yamate Medical Center  Tokyo Japan"},{"name":"Department of Human Pathology, Graduate School of Medicine Juntendo University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4969-8249","authenticated-orcid":false,"given":"Makoto","family":"Kodama","sequence":"additional","affiliation":[{"name":"Department of Human Pathology Graduate School of Institute of Science Tokyo  Tokyo Japan"},{"name":"Division of Biochemistry, Department of Biomedical Sciences Nihon University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,3]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1016\/S0140-6736(16)32126-2","article-title":"Ulcerative colitis","volume":"389","author":"Ungaro R","year":"2017","journal-title":"Lancet"},{"key":"e_1_2_10_3_1","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1093\/ecco-jcc\/jjx008","article-title":"Third European evidence\u2010based consensus on diagnosis and Management of Ulcerative Colitis. 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