{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T02:54:27Z","timestamp":1789095267253,"version":"build-2803163510"},"reference-count":45,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"abstract":"\n Aims<\/jats:title>\n \n Eosinophilic solid and cystic renal cell carcinoma (ESC\u2010RCC) and\n TFEB<\/jats:italic>\n \u2010amplified renal cell carcinoma (\n TFEB<\/jats:italic>\n \u2010amplified RCC, a subset of\n TFEB\u2010<\/jats:italic>\n altered RCC) are rare eosinophilic renal cell tumours that can be difficult to distinguish on the basis of morphology and immunohistochemistry alone. In this study, we compared the clinicopathological and molecular features of these entities to identify distinguishing characteristics.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and results<\/jats:title>\n \n Nine cases of ESC\u2010RCC and six cases of\n TFEB<\/jats:italic>\n \u2010amplified RCC from our institutional archives were evaluated for clinical, morphological, immunohistochemical and molecular features. Despite morphological overlap, each entity exhibited somewhat distinctive features. ESC\u2010RCC frequently exhibited solid and cystic architecture with tightly packed tubules, flocculent to coarsely granular cytoplasm with basophilic stippling and prominent admixed macrophages. In comparison,\n TFEB<\/jats:italic>\n \u2010amplified RCC more frequently demonstrated solid growth of pseudopapillae and loose tubules, dense eosinophilic granular cytoplasm without basophilic stippling, focally apical nuclei and extracellular magenta globules. However, neither morphology nor immunohistochemistry was sufficiently specific to completely distinguish these entities. Ancillary molecular testing identified pathogenic\n TSC1<\/jats:italic>\n or\n TSC2<\/jats:italic>\n gene variants in ESC\u2010RCC and\n TFEB<\/jats:italic>\n gene locus amplification in\n TFEB<\/jats:italic>\n \u2010amplified RCC.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Although ESC\u2010RCC and\n TFEB<\/jats:italic>\n \u2010RCC share overlapping morphological and immunohistochemical features, each demonstrates somewhat characteristic histological findings. Definitive distinction requires molecular testing to identify the underlying molecular alterations. As molecular testing assumes an increasingly important role in RCC diagnosis and classification, recognition of these rare entities and their overlapping and distinguishing features is essential for appropriate testing and accurate diagnosis.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/his.70261","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T08:24:37Z","timestamp":1786609477000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinicopathological and molecular comparison of eosinophilic solid and cystic renal cell carcinoma and\n \n TFEB<\/i>\n <\/scp>\n \u2010amplified renal cell carcinoma: a comprehensive study\u00a0of 15 cases"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2350-6261","authenticated-orcid":false,"given":"Hayley","family":"Zullow","sequence":"first","affiliation":[{"name":"Department of Pathology The University of Chicago Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5869-3175","authenticated-orcid":false,"given":"Melissa Y.","family":"Tjota","sequence":"additional","affiliation":[{"name":"Department of Pathology The University of Chicago Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-1793-2732","authenticated-orcid":false,"given":"Jung Woo","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Pathology The University of Chicago Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0455-9413","authenticated-orcid":false,"given":"Tatjana","family":"Antic","sequence":"additional","affiliation":[{"name":"Department of Pathology The University of Chicago Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,13]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"23","article-title":"WHO 2022 classification of kidney tumors: What is relevant? 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