{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T10:23:57Z","timestamp":1787739837720,"version":"build-2784847793"},"reference-count":20,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"abstract":"\n Background<\/jats:title>\n \n A peripheral nerve sheath tumour composed predominantly of Wagner\u2010Meissner (W\u2010M) bodies is typically regarded as a variant of schwannoma and has been considered rare. Interestingly, a\n SH3PXD2A::HTRA1<\/jats:italic>\n fusion was found which is described in schwannomas with a so\u2010called \u201cserpentine\u201d palisading pattern comprising short palisades of Schwann cells.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We describe a case of plexiform W\u2010M schwannoma with a\n SH3PXD2A::HTRA1<\/jats:italic>\n fusion demonstrated on RNA\u2010based next generation sequencing and review the relevant histological, immunohistochemical and molecular findings and discuss differential diagnoses.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The lesion arose in the distal volar pulp of the right middle finger in a 37\u2010year\u2010old female. It had a plexiform architecture and was composed predominantly of densely packed, repetitive Wagner\u2010Meissner bodies which expressed S100, SOX10, Calretinin and CD56, with intervening S100, SOX10, CD34 and patchy EMA staining. It showed no NF1 expression. A\n SH3PXD2A::HTRA1<\/jats:italic>\n fusion was present.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n The case presented suggests that so\u2010called W\u2010M schwannomas may be driven by\n SH3PXD2A::HTRA1<\/jats:italic>\n fusions and that W\u2010M bodies in this context correlate with the \u2018serpentine\u2019 palisading pattern described in schwannomas with\n HTRA1 rearrangements<\/jats:italic>\n . Analysis of further cases of W\u2010M rich or predominant lesions including schwannoma, neurilemmoma and perhaps even neurotised melanocytic naevi may warrant consideration.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/his.70270","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T10:00:12Z","timestamp":1787738412000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Plexiform Wagner\u2010Meissner schwannoma with a\n \n SH3PXD2A::HTRA1<\/i>\n <\/scp>\n fusion: a twisted sister?"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7959-9671","authenticated-orcid":false,"given":"Mark James","family":"Wilsher","sequence":"first","affiliation":[{"name":"North West London Pathology Imperial College Healthcare NHS Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4835-2422","authenticated-orcid":false,"given":"Onur","family":"Berber","sequence":"additional","affiliation":[{"name":"Royal Free London, NHS Foundation Trust London UK"},{"name":"OS Clinic London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,26]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"856","DOI":"10.2174\/1871527311201070856","article-title":"Clinical implication of Meissner's corpuscles","volume":"11","author":"Vega JA","year":"2012","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"e_1_2_9_3_1","doi-asserted-by":"crossref","DOI":"10.1186\/1746-1596-5-61","article-title":"Solitary neurofibroma of the gingiva with prominent differentiation of Meissner bodies: A case report","volume":"5","author":"Ohno J","year":"2010","journal-title":"Diagn. Pathol."},{"key":"e_1_2_9_4_1","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1111\/cup.13759","article-title":"A meissnerian neurofibroma: Case report of a rare neurofibroma variant","volume":"47","author":"Sode T","year":"2020","journal-title":"J. Cutan. Pathol."},{"key":"e_1_2_9_5_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/dermatopathology10010001","article-title":"Histopathological variants of cutaneous neurofibroma: A compendious review","volume":"10","author":"Nagrani NS","year":"2022","journal-title":"Dermatopathology (Basel)"},{"key":"e_1_2_9_6_1","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/BF00708331","article-title":"Tumour of Wagner\u2010Meissner touch corpuscles. Wagner\u2010Meissner neurilemmoma","volume":"409","author":"Kaiserling E","year":"1986","journal-title":"Virchows Arch. A Pathol. Anat. 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Pathol."},{"key":"e_1_2_9_12_1","first-page":"4713","article-title":"Vessel and mast cell densities in sporadic and syndrome\u2010associated peripheral nerve sheath tumors","volume":"35","author":"Friedrich RE","year":"2015","journal-title":"Anticancer Res."},{"key":"e_1_2_9_13_1","article-title":"A Spectrum of Histomorphological and immunohistochemical expression profiles of S\u2010100, CD56 and calretinin in benign peripheral nerve sheath Tumours","volume":"15","author":"Jaiswal P","year":"2023","journal-title":"Cureus"},{"key":"e_1_2_9_14_1","doi-asserted-by":"crossref","first-page":"30","DOI":"10.4132\/KoreanJPathol.2011.45.1.30","article-title":"Use of calretinin, CD56, and CD34 for differential diagnosis of schwannoma and neurofibroma","volume":"45","author":"Park JY","year":"2011","journal-title":"Korean J. Pathol."},{"key":"e_1_2_9_15_1","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1002\/path.1700850222","article-title":"Verocay bodies and pseudo\u2010meissnerian corpuscles","volume":"85","author":"Dible JH","year":"1963","journal-title":"J. Pathol. Bacteriol."},{"key":"e_1_2_9_16_1","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1111\/his.15544","article-title":"Superficial plexiform schwannoma of the skin and subcutis: Clinicopathological study of 48 cases","volume":"87","author":"Suster DI","year":"2025","journal-title":"Histopathology"},{"key":"e_1_2_9_17_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.modpat.2024.100427","article-title":"Systematic characterization of the clinical and pathological features of schwannomas harboring SH3PXD2A::HTRA1 fusion","volume":"37","author":"Lee JC","year":"2024","journal-title":"Mod. Pathol."},{"key":"e_1_2_9_18_1","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1177\/10935266241308946","article-title":"Clinical and pathological features of a schwannoma harboring a SH3PXD2A::HTRA1 gene fusion in a pre\u2010pubescent patient","volume":"28","author":"Glembocki A","year":"2025","journal-title":"Pediatr. Dev. Pathol."},{"key":"e_1_2_9_19_1","doi-asserted-by":"crossref","DOI":"10.1038\/ng.3688","article-title":"The genomic landscape of schwannoma","volume":"48","author":"Agnihotri S","year":"2016","journal-title":"Nat. Genet."},{"key":"e_1_2_9_20_1","doi-asserted-by":"crossref","DOI":"10.1002\/gcc.70072","article-title":"Widening the Spectrum of fusion events in schwannoma: Identification of a novel TANC1::HTRA1 fusion","volume":"64","author":"Watkins JA","year":"2025","journal-title":"Genes Chromosomes Cancer"},{"key":"e_1_2_9_21_1","doi-asserted-by":"crossref","DOI":"10.1111\/bpa.70084","article-title":"TANC1::HTRA1 fusion in schwannomas","volume":"36","author":"Caliskan I","year":"2026","journal-title":"Brain Pathol."}],"container-title":["Histopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/his.70270","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/his.70270","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/his.70270","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T10:00:16Z","timestamp":1787738416000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/his.70270"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,26]]},"references-count":20,"alternative-id":["10.1111\/his.70270"],"URL":"https:\/\/doi.org\/10.1111\/his.70270","archive":["Portico"],"relation":{},"ISSN":["0309-0167","1365-2559"],"issn-type":[{"value":"0309-0167","type":"print"},{"value":"1365-2559","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,26]]},"assertion":[{"value":"2026-06-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"his.70270"}}