{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:54:54Z","timestamp":1790812494748,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["25K20120"],"award-info":[{"award-number":["25K20120"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study aimed to characterize high\u2010risk human papillomavirus (HR\u2010HPV) infection and the expression patterns of p16, Rb, p53 and cyclin D1 in\u00a0uterine cervical neuroendocrine carcinomas (UCNECs). We also aimed to clarify the similarities and differences between UCNECs and pulmonary neuroendocrine carcinomas (NECs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>\n                      We examined the expression patterns of p16, Rb, p53, and cyclin D1 by immunohistochemistry (IHC) and HR\u2010HPV infection by mRNA in situ hybridization (ISH) in 29 UCNEC cases, along with histological review. Ten pulmonary small cell neuroendocrine carcinomas (SCNECs) were included for comparison. Histologically, most UCNECs were SCNECs combined with adenocarcinoma or squamous cell carcinoma. HR\u2010HPV ISH was performed in 28 UCNEC cases; 27 (96%) were HPV\u2010positive and 1 (4%) was HPV\u2010negative. All HPV\u2010positive cases (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200927) showed p16 overexpression, partial Rb loss, a wildtype p53 pattern, and negative cyclin D1 expression. The single HPV\u2010negative case showed focal p16 positivity, retained Rb expression, a wildtype p53 pattern and positive cyclin D1 expression. In contrast, all 10 pulmonary SCNEC cases were negative for HR\u2010HPV and positive for p16, showing complete loss (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20099) or retained (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20091) Rb expression, and often aberrant p53 expression (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20098; 5 diffuse and 3 null).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Most UCNECs are associated with HPV infection and characterized by p16 overexpression as well as partial loss of Rb. The Rb expression pattern differs between HPV\u2010positive UCNECs and HPV\u2010negative pulmonary NECs, suggesting the potential diagnostic utility of Rb as well as p16.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/his.70290","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:04:31Z","timestamp":1790809471000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Distinct Rb expression pattern in\n                    <scp>HPV<\/scp>\n                    \u2010associated neuroendocrine carcinomas of the uterine cervix"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3092-969X","authenticated-orcid":false,"given":"Nobuko","family":"Yasutake","sequence":"first","affiliation":[{"name":"Department of Gynecology Harasanshin Hospital  Fukuoka Japan"},{"name":"Department of Gynecology and Obstetrics, Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8170-2660","authenticated-orcid":false,"given":"Misato","family":"Komamizu","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"},{"name":"Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5277-2932","authenticated-orcid":false,"given":"Takeshi","family":"Iwasaki","sequence":"additional","affiliation":[{"name":"Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences Kyushu University  Fukuoka 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Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norihito","family":"Yuge","sequence":"additional","affiliation":[{"name":"Department of Gynecology Harasanshin Hospital  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9887-3923","authenticated-orcid":false,"given":"Kenzo","family":"Sonoda","sequence":"additional","affiliation":[{"name":"Department of Gynecology Kyushu University Beppu Hospital  Beppu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3142-8993","authenticated-orcid":false,"given":"Hideaki","family":"Yahata","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Graduate School of Medical Sciences Kyushu University  Fukuoka 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