{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T23:39:43Z","timestamp":1792366783677,"version":"4.4.0"},"reference-count":21,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T00:00:00Z","timestamp":1792281600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T00:00:00Z","timestamp":1792281600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"abstract":"\n Aims<\/jats:title>\n High\u2010grade B\u2010cell lymphoma with 11q aberration is a rare neoplasm of mature B\u2010cell lineage, and large\u2010scale clinicopathological studies of this disease remain scarce. To bridge this research gap, we conducted a retrospective analysis of HGBCL with 11q aberration, aiming to elucidate its pathogenesis, clinicopathological features and molecular profiles.<\/jats:p>\n <\/jats:sec>\n \n Methods and results<\/jats:title>\n \n By reviewing our hospital's case database from 2021 to 2025, we retrospectively screened 92 cases of high\u2010grade or diffuse large B\u2010cell lymphoma that had 11q fluorescence in situ hybridization (FISH) testing. Among them, 27 cases were confirmed to harbour 11q aberration and were enrolled in the present study. This cohort consisted of 24 males and 3 females with a median age of 61\u2009years (range, 6\u201385). Eighteen (67%) patients presented with extranodal disease and nine (33%) had nodal disease. The gastrointestinal tract was the most commonly involved extranodal site (13 patients); two of these patients had concurrent lymph node involvement in the head and neck. Fourteen (52%) patients had advanced Ann Arbor stage (III, IV) disease. Eight (30%) patients had a history of immunocompromise including HIV infection, liver or kidney transplantation and other malignant tumours. The bone marrow was negative for lymphoma at initial diagnosis in all 21 patients assessed. Histologically, 20 (74%) cases had Burkitt\u2010like or blastoid morphology and seven (26%) cases showed diffuse large B\u2010cell\u2010like morphology. Most cases (96%, 26\/27) had a germinal centre B\u2010cell immunophenotype. c\u2010MYC was positive in all 26 tested cases and BCL2 was negative in 24 of 27 (89%) of cases. Mutational analysis was performed in 14 cases and potential driver mutations were identified in all involving 44 genes. The most frequently affected genes included\n TP53<\/jats:italic>\n ,\n IGLL5, DDX3X, BTG2, FOXO1, HIST1H1E<\/jats:italic>\n and\n MYC<\/jats:italic>\n . Following therapy, 24 patients achieved complete remission and disease\u2010free survival. The prognosis was not related to the morphological features, Ann Arbor stage, co\u2010occurrence of\n MYC<\/jats:italic>\n aberrations or the chemotherapy regimens.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n High\u2010grade B\u2010cell lymphoma with 11q aberration may occur across all ages and confers a favourable prognosis. These tumours manifest morphological heterogeneity, and most cases display a Burkitt lymphoma\u2010like immunophenotype characterized by CD10 positivity and BCL2 negativity. The most frequently mutated genes in our cohort are\n TP53<\/jats:italic>\n ,\n IGLL5<\/jats:italic>\n ,\n DDX3X<\/jats:italic>\n ,\n BTG2<\/jats:italic>\n ,\n FOXO1<\/jats:italic>\n ,\n HIST1H1E<\/jats:italic>\n and\n MYC<\/jats:italic>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/his.70303","type":"journal-article","created":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T22:55:37Z","timestamp":1792364137000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Characterization of the morphological, immunophenotypical and cytogenetic features of high\u2010grade B\u2010cell lymphoma with 11q aberration"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-5299-020X","authenticated-orcid":false,"given":"Zhihui","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Pathology The First Affiliated Hospital, Zhejiang University School of Medicine Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1034-163X","authenticated-orcid":false,"given":"Yi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital, Zhejiang University School of Medicine Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7210-4824","authenticated-orcid":false,"given":"Jinghan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital, Zhejiang University School of Medicine Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5557-6878","authenticated-orcid":false,"given":"Liming","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Pathology The First Affiliated Hospital, Zhejiang University School of Medicine Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0187-3212","authenticated-orcid":false,"given":"Han","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology The First Affiliated Hospital, Zhejiang University School of Medicine Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5086-610X","authenticated-orcid":false,"given":"Dan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hematology Shaoxing People's Hospital Shaoxing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7441-3751","authenticated-orcid":false,"given":"Bo","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology The First Affiliated Hospital, Zhejiang University School of Medicine Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7101-5264","authenticated-orcid":false,"given":"Lijun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology The First Affiliated Hospital, Zhejiang University School of Medicine Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9162-6781","authenticated-orcid":false,"given":"Zhaoming","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology The First Affiliated Hospital, Zhejiang University School of Medicine Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1957-3226","authenticated-orcid":false,"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematopathology The University of Texas MD Anderson Cancer Center Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6577-8006","authenticated-orcid":false,"given":"L. Jeffrey","family":"Medeiros","sequence":"additional","affiliation":[{"name":"Department of Hematopathology The University of Texas MD Anderson Cancer Center Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2747-3972","authenticated-orcid":false,"given":"Fang","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Pathology The First Affiliated Hospital, Zhejiang University School of Medicine Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,18]]},"reference":[{"key":"e_1_2_11_2_1","first-page":"486","volume-title":"Haematolymphoid Tumours. WHO classification of Tumours","author":"Lorenzo Leoncini RS","year":"2024"},{"key":"e_1_2_11_3_1","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1182\/blood.2022015851","article-title":"The international consensus classification of mature lymphoid neoplasms: A report from the clinical advisory committee","volume":"140","author":"Campo E","year":"2022","journal-title":"Blood"},{"key":"e_1_2_11_4_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.modpat.2025.100774","article-title":"Cytogenomic and Clinicopathologic comparison of MYC\u2010positive and MYC\u2010negative high\u2010grade B\u2010cell lymphoma with 11q aberration in the context of other aggressive lymphomas with MYC rearrangement","volume":"38","author":"Grygalewicz B","year":"2025","journal-title":"Mod. Pathol."},{"key":"e_1_2_11_5_1","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.3324\/haematol.2018.207928","article-title":"Burkitt\u2010like lymphoma with 11q aberration: A germinal center\u2010derived lymphoma genetically unrelated to Burkitt lymphoma","volume":"104","author":"Gonzalez\u2010Farre B","year":"2019","journal-title":"Haematologica"},{"key":"e_1_2_11_6_1","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1182\/blood-2013-06-507996","article-title":"A recurrent 11q aberration pattern characterizes a subset of MYC\u2010negative high\u2010grade B\u2010cell lymphomas resembling Burkitt lymphoma","volume":"123","author":"Salaverria I","year":"2014","journal-title":"Blood"},{"key":"e_1_2_11_7_1","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.cancergen.2015.12.005","article-title":"The peculiar 11q\u2010gain\/loss aberration reported in a subset of MYC\u2010negative high\u2010grade B\u2010cell lymphomas can also occur in a MYC\u2010rearranged lymphoma","volume":"209","author":"Havelange V","year":"2016","journal-title":"Cancer Genet."},{"key":"e_1_2_11_8_1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1093\/ajcp\/aqx139","article-title":"The 11q\u2010gain\/loss aberration occurs recurrently in MYC\u2010negative Burkitt\u2010like lymphoma with 11q aberration, as well as MYC\u2010positive Burkitt lymphoma and MYC\u2010positive high\u2010grade B\u2010cell lymphoma, NOS","volume":"149","author":"Grygalewicz B","year":"2017","journal-title":"Am. J. Clin. Pathol."},{"key":"e_1_2_11_9_1","doi-asserted-by":"crossref","first-page":"2874","DOI":"10.3324\/haematol.2023.284070","article-title":"The international prognostic index in aggressive B\u2010cell lymphoma","volume":"108","author":"Maurer MJ","year":"2023","journal-title":"Haematologica"},{"key":"e_1_2_11_10_1","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s13027-024-00604-4","article-title":"High\u2010grade B\u2010cell lymphoma with 11q aberration in the HIV setting: A clinicopathological study of 10 cases and literature review","volume":"19","author":"Chang J","year":"2024","journal-title":"Infect. Agent Cancer"},{"key":"e_1_2_11_11_1","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1002\/ajh.70357","article-title":"Mutation profiling, efficacy monitoring, and prognosis evaluation using circulating tumor DNA in peripheral T\u2010cell lymphoma: A prospective, multicenter, observational study","volume":"101","author":"Donglu Z","year":"2026","journal-title":"Am. J. Hematol."},{"key":"e_1_2_11_12_1","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1038\/modpathol.2017.186","article-title":"A comprehensive flow\u2010cytometry\u2010based immunophenotypic characterization of Burkitt\u2010like lymphoma with 11q aberration","volume":"31","author":"Rymkiewicz G","year":"2018","journal-title":"Mod. Pathol."},{"key":"e_1_2_11_13_1","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s00428-023-03590-x","article-title":"Emerging entities: High\u2010grade\/large B\u2010cell lymphoma with 11q aberration, large B\u2010cell lymphoma with IRF4 rearrangement, and new molecular subgroups in large B\u2010cell lymphomas. A report of the 2022 EA4HP\/SH lymphoma workshop","volume":"483","author":"Quintanilla\u2010Martinez L","year":"2023","journal-title":"Virchows Arch."},{"key":"e_1_2_11_14_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.prp.2024.155777","article-title":"Immunodeficiency\u2010related high\u2010grade B\u2010cell lymphoma with 11q aberration: Further evidence for a lymphoma entity from a patient with simultaneous papillary renal cell carcinoma following pediatric kidney transplant","volume":"266","author":"Guazzo R","year":"2025","journal-title":"Pathol. Res. Pract."},{"key":"e_1_2_11_15_1","doi-asserted-by":"crossref","first-page":"e275","DOI":"10.3324\/haematol.2015.124305","article-title":"Post\u2010transplant molecularly defined Burkitt lymphomas are frequently MYC\u2010negative and characterized by the 11q\u2010gain\/loss pattern","volume":"100","author":"Ferreiro JF","year":"2015","journal-title":"Haematologica"},{"key":"e_1_2_11_16_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cancergen.2020.05.001","article-title":"Genetic progression of post\u2010transplant Burkitt\u2010like lymphoma case with 11q\u2010gain\/loss and MYC amplification","volume":"245","author":"Grygalewicz B","year":"2020","journal-title":"Cancer Genet."},{"key":"e_1_2_11_17_1","doi-asserted-by":"crossref","first-page":"5220","DOI":"10.1182\/bloodadvances.2021004635","article-title":"Aggressive B\u2010cell lymphoma cases with 11q aberration patterns indicate a spectrum beyond Burkitt\u2010like lymphoma","volume":"5","author":"Gebauer N","year":"2021","journal-title":"Blood Adv."},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes8060158"},{"key":"e_1_2_11_19_1","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1111\/bjh.14282","article-title":"Sole rearrangement but not amplification of MYC is associated with a poor prognosis in patients with diffuse large B cell lymphoma and B cell lymphoma unclassifiable","volume":"175","author":"Landsburg DJ","year":"2016","journal-title":"Br. J. Haematol."},{"key":"e_1_2_11_20_1","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.humpath.2023.03.013","article-title":"High\u2010grade B\u2010cell lymphoma with concurrent MYC rearrangement and 11q aberrations: Clinicopathologic, cytogenetic, and molecular characterization of 4 cases","volume":"136","author":"Shestakova A","year":"2023","journal-title":"Hum. Pathol."},{"key":"e_1_2_11_21_1","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1097\/PAS.0000000000001613","article-title":"A diagnostic approach to the identification of Burkitt\u2010like lymphoma with 11q aberration in aggressive B\u2010cell lymphomas","volume":"45","author":"Horn H","year":"2021","journal-title":"Am. J. Surg. Pathol."},{"key":"e_1_2_11_22_1","doi-asserted-by":"crossref","first-page":"121","DOI":"10.3960\/jslrt.23007","article-title":"High\u2010grade B\u2010cell lymphoma with 11q aberrations: A single\u2010center study","volume":"63","author":"Yamada S","year":"2023","journal-title":"J. Clin. Exp. Hematop."}],"container-title":["Histopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/his.70303","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/his.70303","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/his.70303","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T22:55:45Z","timestamp":1792364145000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/his.70303"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,18]]},"references-count":21,"alternative-id":["10.1111\/his.70303"],"URL":"https:\/\/doi.org\/10.1111\/his.70303","archive":["Portico"],"relation":{},"ISSN":["0309-0167","1365-2559"],"issn-type":[{"value":"0309-0167","type":"print"},{"value":"1365-2559","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,18]]},"assertion":[{"value":"2026-01-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"his.70303"}}